Polylactic acid/nano hydroxyapatite composite material and its preparation method and application

A nano-hydroxyapatite and composite material technology, applied in the field of biomedicine, can solve the problems of product mechanical properties decline, polylactic acid is easy to thermally degrade, and low impact strength, so as to improve mechanical properties and avoid low impact strength, Minimizes the effect of thermal degradation

Active Publication Date: 2021-04-20
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the present invention aims to propose a preparation method of polylactic acid / nano-hydroxyapatite composite material, to solve the problem of nano-hydroxyapatite in the polylactic acid matrix in the preparation of existing polylactic acid / nano-hydroxyapatite composite material. It is easy to agglomerate, and polylactic acid is easy to thermally degrade, resulting in the decline of mechanical properties and low impact strength of the product.

Method used

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  • Polylactic acid/nano hydroxyapatite composite material and its preparation method and application
  • Polylactic acid/nano hydroxyapatite composite material and its preparation method and application
  • Polylactic acid/nano hydroxyapatite composite material and its preparation method and application

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Embodiment 1

[0032] A preparation method of polylactic acid / nano hydroxyapatite composite material, specifically comprising the following steps:

[0033] 1) Precipitation method is used to prepare nano-hydroxyapatite at 37°C: prepare an aqueous solution of calcium chloride with a concentration of 0.0668mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.04mol / L, and follow the Ca / P molar ratio of 1.67 After mixing the calcium chloride aqueous solution and the diammonium hydrogen phosphate aqueous solution, the pH value of the mixed solution is controlled at 9-10 with a sodium hydroxide aqueous solution with a concentration of 1mol / L, and then heated in a constant temperature water bath at 37°C Stir for 3 hours, then stand still for 24 hours, filter with suction, wash with deionized water, and freeze-dry to obtain white powdery nano-hydroxyapatite with a particle size of 50nm-80nm for subsequent use;

[0034] 2) Polylactic acid / nano-hydroxyapatite compos...

Embodiment 2

[0041] A preparation method of polylactic acid / nano hydroxyapatite composite material, specifically comprising the following steps:

[0042] 1) Precipitation method is used to prepare nano-hydroxyapatite at 37°C: prepare an aqueous solution of calcium chloride with a concentration of 0.0668mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.04mol / L, and follow the Ca / P molar ratio of 1.67 After mixing the calcium chloride aqueous solution and the diammonium hydrogen phosphate aqueous solution, the pH value of the mixed solution is controlled at 9-10 with a sodium hydroxide aqueous solution with a concentration of 1mol / L, and then heated in a constant temperature water bath at 37°C Stir for 3 hours, then stand still for 24 hours, filter with suction, wash with deionized water, and freeze-dry to obtain white powdery nano-hydroxyapatite with a particle size of 50nm-80nm for subsequent use;

[0043] 2) Polylactic acid / nano-hydroxyapatite compos...

Embodiment 3

[0050] A preparation method of polylactic acid / nano hydroxyapatite composite material, specifically comprising the following steps:

[0051] 1) Precipitation method is used to prepare nano-hydroxyapatite at 37°C: prepare an aqueous solution of calcium chloride with a concentration of 0.0668mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.04mol / L, and follow the Ca / P molar ratio of 1.67 After mixing the calcium chloride aqueous solution and the diammonium hydrogen phosphate aqueous solution, the pH value of the mixed solution is controlled at 9-10 with a sodium hydroxide aqueous solution with a concentration of 1mol / L, and then heated in a constant temperature water bath at 37°C Stir for 3 hours, then stand still for 24 hours, filter with suction, wash with deionized water, and freeze-dry to obtain white powdery nano-hydroxyapatite with a particle size of 50nm-80nm for subsequent use;

[0052] 2) Polylactic acid / nano-hydroxyapatite compos...

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Abstract

The invention provides a polylactic acid / nano-hydroxyapatite composite material and its preparation method and application. In the preparation method, firstly, polylactic acid / nano-hydroxyapatite composite microspheres are prepared as a powder raw material by using an emulsion solvent volatilization method, and then , put the powder raw material in a mold, heat and press to form the polylactic acid / nano hydroxyapatite composite material. Adopting the preparation method of the present invention is conducive to the uniform dispersion of nano-hydroxyapatite in the polylactic acid matrix, thereby improving the mechanical properties and impact strength of the product, and it is easy to control the microscopic shape of the molded product. The porogen can obtain microsphere bonded porous structure and microsphere fused dense structure.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a polylactic acid / nano hydroxyapatite composite material and a preparation method and application thereof. Background technique [0002] Polylactic acid (polylactic acid) is a polymer material with good biocompatibility and biodegradability. It has the characteristics of non-toxicity and good thermoformability, and its degradation products can participate in human metabolism. In the field of tissue engineering Medium can meet the requirements as a cell growth carrier material, and is widely used in the field of clinical tissue repair. However, polylactic acid has poor hydrophilicity, and the acidic degradation products can easily cause aseptic inflammation, which is not conducive to cell adhesion and growth. Hydroxyapatite is the main inorganic component of human bones. It has good biocompatibility and bioactivity, good cell affinity, and can form a firm osseointegration wit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/26C08J3/12C08L67/04C08L29/04C08K3/32A61L27/46A61L27/50A61L27/56B29C43/02
CPCA61L27/46A61L27/50A61L27/56A61L2400/12B29C43/02C08J3/12C08J9/26C08J2201/0422C08J2201/0446C08J2329/04C08J2367/04C08J2429/04C08J2467/04C08K2003/325C08K2201/003C08K2201/011C08L67/04
Inventor 韩颖超谢燕萍胡洪钞
Owner WUHAN UNIV OF TECH
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