Carcino-embryonic antigen detection method based on Fe2O3 material single-layer photoelectrochemical sensor

Abstract

The invention relates to the field of carcino-embryonic antigen detection, in particular to a carcino-embryonic antigen detection method based on a Fe2O3 material single-layer photoelectrochemical sensor. The method comprises the following steps: a, preparing a modified alphaFe2O3 photoelectric material, b, assembling the modified alphaFe2O3 photoelectric material in the step a into a detection electrode system, and c, quantitatively detecting the carcino-embryonic antigen by adopting the assembled electrode system in the step b. The method has the advantages of high sensitivity, high selectivity and low detection limit, and is beneficial to early diagnosis and disease monitoring of malignant tumors.

Description

technical field [0001] The invention relates to the field of carcinoembryonic antigen detection, in particular to a carcinoembryonic antigen detection method based on Fe2O3 material single-layer photoelectrochemical sensor. Background technique [0002] At present, the commonly used traditional methods for the detection of tumor markers include enzyme-linked immunosorbent assay (ELISA), electrochemiluminescence (ECL), fluorescent immunoassay (IFA), mass spectrometry and other immunoassay methods. [0003] The defects in the above detection methods include: 1. The excitation source and the detection signal are the same, both being electrical (optical) signals. 2. The input of larger sample volume is required. 3. Large and complex instruments and equipment are required. 4. The time period is long. [0004] Carcinoembryonic antigen (CEA), an acidic glycoprotein with the characteristics of human embryonic antigen, exists on the surface of cancer cells differentiated from endo...

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Problems solved by technology

[0003] The defects in the above detection methods include: 1. The excitation source and the detection signal are the same, both are electrical (optical) signals

2. The input of a larger sample volume is required

3. Need to use large and complex instruments and equipment

4. Long time period

[0006] However, the photoelectrochemical method used to detect the concentration of cancer blank antigens in the prior art mostly uses double-layer photoelectric immunosensors, which have wide light absorption band gaps, low photoelectric absorption efficiency, and high detection limits, and cannot measure low-concentration cancer blank antigens. , which is not conducive to the early diagnosis and condition monitoring of malignant tumors

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