CircSPECC1 for treating human kidney cancer and application thereof

A technology of mir-615, which is applied in the field of gene medicine, can solve the problem that the function of circRNAs has not been discovered, and achieve far-reaching effects of prevention and treatment

Pending Publication Date: 2020-06-26
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, circRNAs have gradually become a hotspot in the field of RNA and cancer research, but the functions of most circRNAs have not yet been discovered

Method used

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  • CircSPECC1 for treating human kidney cancer and application thereof
  • CircSPECC1 for treating human kidney cancer and application thereof
  • CircSPECC1 for treating human kidney cancer and application thereof

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Embodiment Construction

[0045] This patent provides a variety of parallel schemes, and the different expressions belong to the improved scheme based on the basic scheme or the parallel scheme. Each scheme has its own unique characteristics.

[0046] The role of circ RAN in the proliferation and metastasis of human renal cancer provides a new idea for the prevention and treatment of human renal cancer metastasis

[0047] YB-1 (Y-box binding protein-1) is a member of the cold shock protein superfamily, which contains a highly conserved nucleic acid sequence and is a multifunctional protein. YB-1 is involved in a series of DNA / RNA-dependent events, such as DNA repair, mRNA alternative splicing, regulation of mRNA stability and translation, and plays an important role in cell proliferation, differentiation, stress response and transformation of malignant cells biological function. The previous research of the project team found that YB-1 is overexpressed in human kidney cancer tissue and plays a key ro...

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Abstract

The invention relates to the field of gene medical treatment, and particularly relates to circSPECC1 for treating human kidney cancer and application thereof. The invention relates to application of the circSPECC1 for treating human kidney cancer in preparing a medicine for treating human kidney cancer. The beneficial effects are as follows: based on the gene of human kidney cancer OS-RC-2 cell YB-1, the circSPECC1 interacts with miR-615 to target and regulate the expression of HIP1 (Huntington Interaction Protein 1) and Caspase 9 gene, plays an important role in invasion and proliferation ofhuman kidney cancer, and can effectively inhibit the proliferation and invasion ability of human kidney cancer OS-RC-2 cells by inhibiting circSPECC1. The implementation of the project has important significance for filling the gap of human kidney cancer biotherapy and perfecting the current human kidney cancer comprehensive treatment measures, and also has far-reaching significance for preventingand treating tumors of other tissues and organs.

Description

technical field [0001] The present invention relates to the field of gene medicine, in particular to a circSPECC1 for treating human kidney cancer and its use. Background technique [0002] Research status and existing problems of human renal carcinoma [0003] Human kidney cancer, also known as human renal cell carcinoma (Renal cell carcinoma, RCC), has been increasing in incidence in recent years, accounting for 2% to 3% of adult malignant tumors, accounting for 80% to 90% of primary renal malignant tumors, and the mortality rate is as high as 40%. At present, the treatment methods for human RCC mainly include surgery, chemotherapy, radiotherapy, biological therapy, hyperthermia and targeted therapy. However, even after surgical treatment of early patients, there are still some patients who will metastasize. The prognosis of metastatic renal cell carcinoma is poor, and it is not sensitive to radiotherapy, chemotherapy and other treatments, and the average 3-year surviva...

Claims

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Application Information

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IPC IPC(8): C12N15/113C12Q1/6886A61K45/00A61P35/00A61P13/12
CPCC12N15/113C12Q1/6886A61K45/00A61P35/00A61P13/12C12N2310/532C12Q2600/158C12Q2600/178C12Q2600/118C12Q2600/106C12Q2600/136
Inventor 郑瑾兰平王颖王婧雯张江伟
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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