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Method and device for manufacturing microneedle having coating part on tip thereof

A microneedle and coating technology, applied in the direction of microneedles, needles, coatings, etc., can solve the problems that microneedles cannot be inserted into the skin and target substances cannot penetrate, and achieve the effect of effective and accurate coating in quantity and time

Active Publication Date: 2020-07-03
LG HOUSEHOLD & HEALTH CARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In the past, when the microneedles were pressed by hand and inserted into the skin, some of the microneedles could not be inserted into the skin, so there was a problem that the target substance hardly penetrated

Method used

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  • Method and device for manufacturing microneedle having coating part on tip thereof
  • Method and device for manufacturing microneedle having coating part on tip thereof
  • Method and device for manufacturing microneedle having coating part on tip thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0066] Step 1. Fabrication of Microneedle Coating Solution

[0067] As shown in Table 1 below, microneedle coating solutions were produced. In this specification, unless otherwise specified, the content of the composition is expressed in % by weight. After dissolving CMC (Carboxymethyl cellulose: carboxymethyl cellulose) in purified water, Tween-80 (Tween 80) and trypan blue (Trypan blue) were added to prepare a solution.

[0068] [Table 1]

[0069] Content (weight%) CMC 8 Tween 80 5 Trypan blue 15 water to 100

[0070] Step 2. Fabrication of a double layer mold with attached film for masking

[0071] Areas of a microneedle mold structure (first layer) composed of PDMS material and a masking film (second layer) composed of silicone resin material and having a thickness of about 100 to 200 μm were fabricated in the same manner. The holes of the masking film (second layer) were made such that they coincided with the positions of the i...

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PUM

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Abstract

The present invention relates to a method for manufacturing a microneedle having a coating part formed on only the tip thereof so as to be impregnated with a target material, and a microneedle mold usable by the method. When a microneedle is manufactured by using a coating method and device according to the present invention, a coating part impregnated with a target material can be easily insertedinto and effectively dissolved in the skin. Further, the target material is allowed to show excellent skin permeation with the dissolution of the coating part of the microneedle manufactured according to the present invention, whereby a predetermined amount of the target material can be effectively delivered into the skin.

Description

technical field [0001] This application claims priority based on Korean Application No. 10-2017-0158495 filed on November 24, 2017, and uses all the contents disclosed in the specification and drawings of this application for this application. [0002] The present invention relates to a method of manufacturing a microneedle having a coated portion at the tip and an apparatus used for the method. In more detail, the present invention relates to a method of manufacturing a microneedle in such a manner that a coating portion impregnated with a target substance is formed only on the needle tip, and a microneedle mold usable for the above method. Background technique [0003] Various methods for efficiently transdermally administering a target substance have been studied. However, since the skin surface layer has a barrier function to prevent foreign substances from entering the body, it is difficult to absorb a sufficient amount of the target substance to exert the desired effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C41/38B29C41/02B29C33/48A61M37/00B29C33/00B29L31/00
CPCB29C45/263B29C2045/0079B29C45/0053B29C33/56A61M37/0015A61M2037/0046A61M2037/0053B29C39/026B29K2995/0062B29C41/38B29C41/02B29C33/48B29C2033/0094B29K2909/02B29L2031/7544A61M2037/0023B29C33/3857B29C41/22
Inventor 黄英暋沈愚先姜来圭
Owner LG HOUSEHOLD & HEALTH CARE LTD