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Freeze-dried powder injection of broad-spectrum antiviral drug triazavirin and preparation method thereof

A technology of antiviral drugs and freeze-dried powder injections, which is applied in the field of medicine and can solve the problem of taking large doses

Active Publication Date: 2022-03-15
宁夏蓝博思化学技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drug market is mainly based on tablets and capsules, but because the drug is very water-soluble, it metabolizes very quickly after entering the human body, so that the drug can be effectively inhibited by taking a large dose

Method used

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  • Freeze-dried powder injection of broad-spectrum antiviral drug triazavirin and preparation method thereof
  • Freeze-dried powder injection of broad-spectrum antiviral drug triazavirin and preparation method thereof
  • Freeze-dried powder injection of broad-spectrum antiviral drug triazavirin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Accurately weigh 1.0g of β-cyclodextrin, add it to 100mL of water for injection, and then add 0.05g of EDTA after ultrasonic dissolution, 1.0g of broad-spectrum antiviral drug Triazavirin, add 20g of low-molecular dextran and stir to dissolve completely after ultrasonic dissolution, then Add 2.0g of activated carbon, stir for decolorization and adsorption for 45min to filter, add 0.5g of sodium chloride to the filtrate, adjust the pH to 7.5 with disodium hydrogen phosphate after dissolving, retest after 15min and stabilize the pH at 7.5, then filter and sterilize with a 0.2μm membrane. The filtrates were respectively canned in 2mL ampoules, and the canned volume was 1mL / bottle. After packaging, they were placed in a lyophilizer to freeze-dry, and after 36 hours, they were taken out and sealed to obtain the broad-spectrum antiviral drug Triazavirin freeze-dried powder injection.

Embodiment 2

[0028] The proportion of each component of the broad-spectrum antiviral drug Triazavirin freeze-dried powder injection is as follows, and its preparation process is as in Example 1, and the specific proportions are as follows:

[0029]

[0030]

Embodiment 3

[0032] The proportion of each component of the broad-spectrum antiviral drug Triazavirin freeze-dried powder injection is as follows, and its preparation process is as in Example 1, and the specific proportions are as follows:

[0033]

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PUM

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Abstract

The invention discloses a novel freeze-dried powder injection of broad-spectrum antiviral drug Triazavirin and a preparation method of the freeze-dried powder injection. The new freeze-dried powder injection is composed of broad-spectrum antiviral drug Triazavirin, β-cyclodextrin, low-molecular-weight dextran, EDTA, pH regulator and osmotic pressure regulator. The method provided by the invention is to add β-cyclodextrin into water for injection, add an appropriate amount of EDTA after dissolving, then add an appropriate amount of broad-spectrum antiviral drug Triazavirin and low-molecular-weight dextran to stir to make the main drug completely dissolve, and then treat with activated carbon Finally, add an osmotic pressure regulator, then use a pH regulator to adjust the pH to 7.5-8.5, and finally fill it in an ampoule, freeze-dry, and seal to obtain a freeze-dried powder injection of the broad-spectrum antiviral drug Triazavirin. The broad-spectrum antiviral Triazavirin freeze-dried powder injection prepared by the invention has the advantages of low water content, good appearance, low related impurities, etc., and is suitable for long-term storage.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a freeze-dried powder injection of a broad-spectrum antiviral drug Triazavirin and a preparation method thereof. Background technique [0002] Triazavirin is a new broad-spectrum antiviral drug developed by the Institute of Chemical Technology of Ural State University in Russia in 2014. This drug helps to delay the treatment of acute respiratory viral infections and influenza, improve health status on the first day, and reduce the possibility of complications , quickly stop the clinical symptoms of coronavirus infection, prevent the disease from worsening, and effectively fight against RNA virus infection. [0003] Triazavirin is currently conducting clinical trials in China as an anti-epidemic support material provided by the Russian government (Multicenter, randomized, double-blind, placebo trial of the efficacy and safety of Triazavirin in the treatment of patients with 201...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K47/40A61K47/26A61K47/12A61K47/18A61K47/02A61K31/708A61P31/12
CPCA61K9/19A61K9/0019A61K47/40A61K47/26A61K47/12A61K47/183A61K47/02A61K31/708A61P31/12
Inventor 杨文茂王勇余翔唐磊马龙
Owner 宁夏蓝博思化学技术有限公司