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A preparation method of anti-intestinal adhesion bilayer biogel and bilayer biogel

A biological gel and intestinal adhesion technology, applied in the field of biomedicine, can solve problems such as intestinal adhesions that cannot be relieved and have not been resolved

Active Publication Date: 2021-03-12
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are two solutions to intestinal adhesions, one is conservative treatment, that is, diet control, medication and exercise, which can relieve the pain caused by intestinal adhesions but cannot relieve intestinal adhesions; the other is to relieve intestinal adhesions. Secondary surgery for intestinal adhesions, but secondary surgery may create new intestinal adhesions
The problem of intestinal adhesions is currently unresolved in the medical community

Method used

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  • A preparation method of anti-intestinal adhesion bilayer biogel and bilayer biogel
  • A preparation method of anti-intestinal adhesion bilayer biogel and bilayer biogel
  • A preparation method of anti-intestinal adhesion bilayer biogel and bilayer biogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method of anti-intestinal adhesion bilayer biogel, comprising the following steps:

[0044] S1: preparing chitosan solution in advance;

[0045] The pre-prepared chitosan solution in S1 is specifically: dissolving chitosan with a mass volume fraction of 3% w / v in 1% acetic acid, stirring with a magnetic stirrer, adjusting the stirrer speed to 1000r / min, Stir for 24h. It should be noted that the mixed solution of chitosan and acetic acid should be shaken evenly at room temperature before stirring with a magnetic stirrer. In addition, the volume of chitosan can be calculated based on the mass-volume ratio of 3% w / v. Personnel in the field are familiar with the process, and will not repeat it here.

[0046] The chitosan described in S1 has a deacetylation degree of 75%, a molecular weight of 310000 g·mol-1, and a viscosity of 800. The higher the degree of deacetylation of chitosan, the better the dissolution of chitosan.

[0047] S2: preparing pure methacry...

Embodiment 2

[0069] A method for preparing an anti-intestinal adhesion double-layer biogel, other features are the same as in Example 1, the difference is that: the pre-prepared chitosan solution in S1 is specifically: a shell with a mass volume fraction of 10% w / v The polysaccharide was dissolved in 5% acetic acid, stirred with a magnetic stirrer at a speed of 1000 r / min, and stirred for 48 hours.

[0070] The chitosan described in S1 has a deacetylation degree of 90%, a molecular weight of 375000 g·mol-1, and a viscosity of 2000.

[0071] Adding methacrylic anhydride dropwise in S2 is specifically: stirring and heating the chitosan solution to 60°C in an oil bath, adding 95% methacrylic anhydride dropwise to the chitosan solution at a speed of 1ml / min with a concentration of Stir with a magnetic stirrer at a speed of 1000r / min for 6h.

[0072] The mass volume concentration of the methacrylated chitosan solution in S3 is 10% w / v.

[0073] Weigh respectively 5mmol of 1-(3-dimethylaminopr...

Embodiment 3

[0082] A preparation method of an anti-intestinal adhesion double-layer biogel, other features are the same as in Example 1, the difference is that: the pre-prepared chitosan solution in S1 is specifically: a shell with a mass volume fraction of 5% w / v The polysaccharide was dissolved in 3% acetic acid, stirred with a magnetic stirrer, the speed of the stirrer was adjusted to 1000r / min, and stirred for 36h.

[0083] The chitosan described in S1 has a deacetylation degree range of 83%, a molecular weight of 350000 g·mol-1, and a viscosity of 1500.

[0084] Adding methacrylic anhydride dropwise in S2 is specifically: stirring and heating the chitosan solution to 55° C. in an oil bath, adding 94.5% methacrylic anhydride dropwise to the chitosan solution at a speed of 0.75 ml / min, Stir with a magnetic stirrer at a speed of 1000r / min, and stir for 5h.

[0085] The mass volume concentration of the methacrylated chitosan solution in S3 is 6% w / v.

[0086] Weigh respectively 4.5mmol...

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Abstract

The preparation method of an anti-intestinal adhesion double-layer biogel provided by the present invention comprises the following steps: S1: preparing chitosan solution in advance; S2: preparing pure methacrylated chitosan; S3: preparing methyl Acrylated chitosan solution; S4: preparation of pure HA-DA-AEMA; S5: preparation of HA-DA-AEMA solution; S6: curing HA-DA-AEMA solution and methacrylated chitosan solution respectively An inner biogel that adheres to tissues and an outer biogel that resists adhesion. The inner layer of biogel that adheres to the tissue can be tightly combined with the surface of the intestine, which can fix the intestinal wound and prevent inflammatory exudation and bleeding. The anti-adhesion outer layer of biogel can avoid adhesion to the tissue. The viscous surface of the inner biogel adheres to the abdominal cavity or other intestinal tracts, avoiding the pain caused by intestinal adhesions to patients.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a preparation method of an anti-intestinal adhesion double-layer biogel and the double-layer biogel. Background technique [0002] Intestinal adhesion is a common surgical system disease, which is abnormal adhesion between intestinal tube and intestinal tube or between intestinal tube and abdominal viscera. [0003] After the formation of intestinal adhesions, some adhesions may restrict the peristalsis of the intestinal tube or pull the intestinal tube, resulting in long-term paroxysmal abdominal pain or abdominal distension; when intestinal adhesions cause incomplete intestinal obstruction, although food can pass through the intestinal tube at this time, the adhesion It will cause the speed of food passing through the intestinal tube here to be slow, and the patient will experience nausea and paroxysmal abdominal pain and abdominal distension after meals; when complete intestinal obs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14
CPCA61L31/042A61L31/06A61L31/14A61L31/145A61L2400/04C08L79/02C08L5/08
Inventor 黄文华吴耀彬伍笑棋许益超
Owner SOUTHERN MEDICAL UNIVERSITY
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