Compositions with improved dissolution properties

A technology of composition and acidic polymer, which is applied in the field of medicine, can solve the problems of insufficient physical stability, research, and dissolution test, etc., and achieve the effect of improving dissolution rate and solubility, good stability, and facilitating absorption
CN111467501BActive Publication Date: 2021-06-15NEOFORM BIOPHARMACEUTICAL LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NEOFORM BIOPHARMACEUTICAL LTD
Publication Date
2021-06-15

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Abstract

The present invention relates to a composition with improved dissolution properties, comprising a salt formed of a basic tinib drug molecule and an acidic polymer. The composition with improved dissolution properties comprises a salt formed of a basic tinib drug molecule and an acidic polymer, the basic tinib drug is dispersed in the acidic polymer at a molecular level to form an amorphous solid dispersion, and the base An ionic bond is formed between the tinib drug molecule and the acidic polymer, which has good stability, improves the dissolution rate and solubility of the composition, and is beneficial to be absorbed by patients.
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Description

technical field

[0001] The present invention relates to the field of medicine, and more particularly, to a composition with improved dissolution properties. Background technique

[0002] Tini drugs are tyrosine kinase inhibitors, which are a change to the traditional cancer treatment plan, because they have a very high selectivity for cancer cells, so that they do not kill normal cells, and have become one of the first-line anti-tumor drugs. one. Although it has been widely used in clinical practice, solid oral drugs of tinib have the problems of poor water solubility and low bioavailability, and the clinical dosage is relatively high.

[0003] The recommended dose of commercially available Sorafenib tablets is 400 mg each time, twice a day, for the treatment of advanced renal cell carcinoma and primary hepatocellular carcinoma. The absolute bioavailability of the drug is low, generally considered to be less than 50%, and only 8.43% in rats (Biomaterials 2014, 35, 4565). ...

Claims

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