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Temozolomide response predictor and methods

A technology of temozolomide and reaction, which is applied in the field of drug reaction of temozolomide, and can solve problems such as analysis selection that does not propose response prediction

Inactive Publication Date: 2020-08-04
NANTOMICS LLC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, the authors do not present any analytical choices that would support or imply response prediction with clinically usable predictive accuracy

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  • Temozolomide response predictor and methods
  • Temozolomide response predictor and methods
  • Temozolomide response predictor and methods

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[0058] Archived FFPE tissue sections were obtained from 41 patients with metastatic colorectal cancer from the FELDSPAR cohort who had received TMZ in one of 3 phase II clinical trials. As shown in Table 1, tumor samples from 41 TMZ-treated patients were available for analysis. The patients had a median age of 69 years and had received a median of 3 chemotherapy regimens prior to TMZ. Most patients had an ECOG status of 0 or 1 (85%); and at least 2 metastatic sites (56%), with the liver being the most common site. As expected in mCRC, all patients eventually progressed to TMZ. ORR was as follows: 26 patients (63%) had progressive disease; 9 (22%) had partial response; 6 (15%) had stable disease. Such as figure 1 As shown, among these 41 samples, 39 successfully passed the quality control criteria for RNAseq sequencing, and 35 successfully passed the quality control criteria for methyl BEAMing (digital MB). The following is a brief analysis of this sample selection.

[005...

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Abstract

Contemplated systems and methods use a response prediction model for temozolomide that is based on RNAseq information, protein quantitative information, and methylation information and has a prediction accuracy of at least 85%.

Description

[0001] This application claims priority to our co-pending U.S. Provisional Applications Serial No. 62 / 579,127, filed October 30, 2017, and Serial No. 62 / 727,245, filed September 5, 2018, both of which are filed as It is incorporated herein in its entirety. technical field [0002] The field of the invention is systems and methods for predicting drug response to temozolomide in a patient, particularly in the case of a patient diagnosed with cancer. Background technique [0003] The Background Description includes information useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, nor is any publication specifically or implicitly referenced to be prior art. [0004] All publications and patent applications herein are incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated...

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Application Information

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IPC IPC(8): G16B30/00G16B20/00G16B40/00G16B5/00
CPCG16B20/00G16B40/20G16B5/00
Inventor 克里斯托弗·W·赛托赛提塔·维拉帕内尼斯蒂芬·本茨
Owner NANTOMICS LLC