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Ophthalmic medicament and preparation method thereof

An ophthalmic and pharmaceutical technology, applied in the field of medicine, can solve the problems of no broad-spectrum, no effective treatment, irritation, etc., and achieve the effect of improving antiviral efficacy, improving antiviral effect, and suppressing virus

Inactive Publication Date: 2020-08-07
GUANGZHOU SHENGPU INVESTMENT MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there have been a large number of studies on antiviral ophthalmic preparations, but their therapeutic effects are limited, and they often only target symptoms caused by a limited number of viruses without a broad spectrum. For example, clinical studies have shown that povidone-iodine Eye drops have only limited effectiveness while causing additional irritation in the inflamed eye and sometimes even discoloration of the conjunctiva; patent CN201580005116.7 discloses a composition effective against viral conjunctivitis using iota-carrageenan Glue as an antiviral active ingredient can only treat viral eye infections caused by adenovirus of subtype D or influenza A virus of H7 subtype
In particular, the novel coronavirus (SARS-CoV-2) that caused the pneumonia epidemic broke out globally at the end of 2019. Its course of disease can progress rapidly and even cause death. The fatality rate is extremely high and the harm is great. conjunctivitis, there is no effective treatment, and there is no unified standard of treatment

Method used

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  • Ophthalmic medicament and preparation method thereof
  • Ophthalmic medicament and preparation method thereof
  • Ophthalmic medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 emblica extract

[0038]The fresh emblica fruit is dried and crushed to make powder. Weigh 100g of emblica powder, wrap it with filter paper, put it into a Soxhlet extractor, add 1000g of deionized water to Soxhlet for extraction for 4 hours, recover the water extract, concentrate it on a water bath and constant volume, and obtain the remaining Ganzi water extract.

Embodiment 2

[0039] The preparation of embodiment 2 emblica extract

[0040] The fresh emblica fruit is dried and crushed to make powder. Weigh 100g of emblica powder, wrap it with filter paper, put it into a Soxhlet extractor, add 200g of neutral deionized water for Soxhlet extraction for 2 hours, recover the water extract, concentrate it on a water bath and constant volume, to obtain Amla water extract.

Embodiment 3

[0041] The preparation of embodiment 3 emblica extract

[0042] The fresh emblica fruit is dried and crushed to make powder. Weigh 100g of emblica powder, wrap it with filter paper, put it into a Soxhlet extractor, add 1200g of neutral deionized water for Soxhlet extraction for 6 hours, recycle the water extract, concentrate and constant volume on a water bath, to obtain Amla water extract.

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Abstract

The invention discloses an ophthalmic medicament and a preparation method thereof. The ophthalmic medicament comprises a phyllanthus emblica extract and water for injection. The ophthalmic medicamentcan provide a protective effect on viruses capable of being infected by eyes in a targeted manner; experimental research shows that the ophthalmic medicament has relatively efficient broad-spectrum antiviral activity, particularly has a remarkable treatment effect on new coronavirus and influenza virus, can effectively inhibit infection and propagation of the viruses, and has good prevention and control significance on propagation of diseases caused by virus infection on human bodies. The main effective components of the ophthalmic medicament are from natural plants, so that the ophthalmic medicament has the advantages of naturalness, safety, mild drug effect and the like, and the preparation method is simple, low in cost and very good in application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to an ophthalmic medicament and a preparation method thereof. Background technique [0002] The eye is one of the main routes of virus infection. The virus can cause the body to be infected through direct or indirect contact with the eye, including splashes (such as blood splashes, splashes during intubation, etc.) and droplet transmission (sneezing) Or cough), contact transmission (such as hand rubbing eyes), fecal-ocular transmission, nose-ocular transmission, oral-ocular transmission (through contaminated hands or objects), and transmission of eye secretions and tears, etc. Common viruses that can infect the eyes include: herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (Cytomegalovirus), adenovirus (Adenovirus), human-acquired Immunodeficiency virus (Humanimmunodeficiency virus, HIV), Zika virus (ZIKV), Lassa virus (Lassa virus, LASV),...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61K9/08A61P27/02A61P31/12A61P31/14A61K31/191A61K31/315A61K33/30
CPCA61K36/47A61K33/30A61K31/191A61K31/315A61K9/0048A61K9/08A61P27/02A61P31/12A61P31/14A61K2236/331A61K2300/00
Inventor 付军
Owner GUANGZHOU SHENGPU INVESTMENT MANAGEMENT
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