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Nano-photosensitive compound targeting epilepsy cells and its regulatory detection system

A compound and photosensitizing drug technology, which can be applied to nervous system diseases, photodisintegration of drugs in the body, non-active components of polymer compounds, etc. Damage and other issues, to achieve the effect of improving temporal and spatial resolution, reducing side effects, reducing dispersion and loss

Active Publication Date: 2022-05-31
AEROSPACE INFORMATION RES INST CAS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical methods for the treatment of epilepsy mainly include drug therapy, surgical resection, and brain stimulation therapy, but these methods have problems such as large side effects, re-injury, and low accuracy, and lack of targeted therapy with high spatiotemporal resolution

Method used

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  • Nano-photosensitive compound targeting epilepsy cells and its regulatory detection system
  • Nano-photosensitive compound targeting epilepsy cells and its regulatory detection system
  • Nano-photosensitive compound targeting epilepsy cells and its regulatory detection system

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Embodiment Construction

[0049] (2) A single-layer lipid film was formed by rotary evaporation, and the reaction condition was 37° C., and the evaporation time was 15 minutes.

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Abstract

A nano-targeted photosensitive complex, wherein the nano-targeted photosensitive complex includes nano-liposomes, photosensitive drugs wrapped inside the liposomes, and targeting molecular groups connected to the outer surface of the nano-lipids. The invention also discloses the preparation method of the nano-targeted photosensitive compound and the regulation and detection system established by using it. The nano-targeted photosensitive compound has strong biocompatibility, improves the utilization rate of the wrapped drug, and can treat the lesion area Nerve cells are targeted for regulation. The neural regulation detection system prepared by using the compound can realize synchronous recording of neural signals under targeted regulation, and has good spatiotemporal resolution.

Description

Nanophotosensitive complexes targeting epilepsy cells and their regulatory detection system technical field The present invention relates to the field of biomedical basic research, targeted nanomedicine regulation and neural signal detection, in particular And a nano-targeted photosensitive complex for regulating epilepsy lesion nerve cells and a regulation and detection system established by using the same. Background technique Epilepsy is the second largest central nervous system disease after cerebrovascular disease, and the factors that cause epilepsy are usually more Complex, and different types of epilepsy lesions are not the same. Epilepsy will continue to affect the patient's psychological cognition and basic life. It can cause serious psychological disorders and functional damage, and even lead to death, which will bring great harm to the patient's family and society. pressure. The current clinical methods for treating epilepsy mainly include drug therapy,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K41/00A61K31/198A61K31/197A61K47/24A61K47/28A61K47/26A61K47/42A61P25/08A61B5/00A61B5/367A61N5/06
CPCA61K9/1271A61K41/0042A61K31/198A61K31/197A61K47/24A61K47/28A61K47/26A61K47/42A61P25/08A61N5/062A61B5/4094A61B5/6868A61N2005/0612A61N2005/063A61N2005/0626A61B2503/40A61B2503/42A61B5/24
Inventor 戴玉川蔡新霞宋轶琳谢精玉李轩宇王昊肖桂花郑文富蒋兴宇
Owner AEROSPACE INFORMATION RES INST CAS
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