Graphene oxide drug carrier and its preparation method and application
A graphene and drug technology, applied in the field of graphene oxide drug carrier and its preparation, can solve problems such as lack of reaction ability, achieve high carrying ability, improve water solubility, and safe anti-tumor effect.
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Embodiment 1
[0050] This embodiment provides a graphene oxide drug carrier GO-PEG-OSA, the preparation method of which comprises the following steps:
[0051] (1) Preparation of graphene oxide dispersion
[0052] Weigh a certain amount of micron-sized graphene oxide, disperse it into distilled water to prepare a suspension with a mass concentration of 10 mg / ml, and then use an ultrasonic disperser to intermittently ultrasonicate at 4°C for 24 hours with an ultrasonic power of 600w; then centrifuge at 5000rpm for 10min, The supernatant was collected and then freeze-dried to obtain nano-graphene oxide with a particle size of about 100 nm.
[0053] Weigh a certain amount of nano-graphene oxide, disperse it with distilled water, and prepare a nano-graphene oxide dispersion liquid with a mass concentration of 5 mg / ml. Then add 1 mol / L sodium hydroxide solution, adjust the pH of the dispersion to 10, stir magnetically at room temperature for 1 hour, then centrifuge at 6000 rpm, and discard the ...
Embodiment 2
[0067] The present embodiment provides a kind of nano medicine, and its preparation method is as follows:
[0068] Take a certain amount of GO-PEG-OSA of Example 1 and disperse it in distilled water to prepare a GO-PEG-OSA dispersion with a concentration of 5 mg / L. Take 2ml of GO-PEG-OSA dispersion, add 200μL of PTX solution, stir the mixture at 4°C for 12h, and then centrifuge at 10000rpm for 20min. Subsequently, the supernatant was collected and the content of free PTX was measured by high performance liquid chromatography (HPLC). The precipitate was dispersed again with distilled water and freeze-dried to obtain the PTX-loaded nanomedicine PTX@GO-PEG-OSA.
[0069] As a comparison, when GO-PEG-OSA is replaced with GO-PEG prepared in step (2) of Example 1 during the preparation of nanomedicine, another nanomedicine PTX@GO-PEG can be obtained.
[0070] performance testing
[0071] (1) Sustained release effect
[0072] According to different release environments, the sample...
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