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A traditional Chinese medicine composition for treating sepsis myocardial injury and preparation method thereof
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A technique for myocardial injury and composition, applied in the field of traditional Chinese medicine compositions, can solve the problems of cardiac dysfunction without significantly reducing morbidity and mortality, and achieve the effects of inhibiting inflammatory response, reducing mortality, and improving therapeutic effect
Active Publication Date: 2022-05-06
ZHENGZHOU RAILWAY VOCATIONAL & TECH COLLEGE
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Traditional Chinese medicine believes that patients with sepsis are due to the internal resistance of blood stasis and evil toxins, which in turn damage the organs and cause myocardial damage. However, the current treatment of cardiac dysfunction has not significantly reduced the incidence of myocardial damage in sepsis. rate and mortality, there is no Chinese medicine composition that has a significant therapeutic effect on myocardial injury caused by sepsis
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Embodiment 1
[0022] A traditional Chinese medicine composition for treating septic myocardial injury, comprising the following raw materials in parts by weight: 20 parts of Zizhugen, 18 parts of symphylla, 15 parts of Zoumafeng, 10 parts of dendrobium, 12 parts of cat's eye grass, and 8 parts of mulberry seeds , 5 parts of Jiaogulan, 5 parts of seabuckthorn, 8 parts of tea tree seeds, 3 parts of dandelion, 3 parts of Shanzi mushroom, 1 part of licorice.
[0023] The preparation method of the above-mentioned Chinese medicine composition for treating sepsis myocardial injury comprises the following steps:
[0024] (1) Take purple bamboo root and magma fruit, wash and chop, add water 5 times the weight of the solid material, and extract under microwave pressure for 30 minutes at a temperature of 65 ° C and a pressure of 0.2 MPa. After the microwave extraction is completed, carry out solid-liquid extraction Separate the extract, filter and concentrate the extract to obtain an extract with a re...
Embodiment 2
[0029] A traditional Chinese medicine composition for treating septic myocardial injury, comprising the following raw materials in parts by weight: 18 parts of Zizhugen, 19 parts of philodendron, 17 parts of Zoumafeng, 12 parts of dendrobium, 14 parts of cat's eye grass, and 8 parts of mulberry seeds , 7 parts of Jiaogulan, 7 parts of seabuckthorn, 8 parts of tea tree seeds, 4 parts of dandelion, 4 parts of Shanzi mushroom, and 2 parts of licorice.
[0030] The preparation method of the above-mentioned Chinese medicine composition for treating sepsis myocardial injury comprises the following steps:
[0031] (1) Take purple bamboo root and magma fruit, wash and chop, add water 6 times the weight of the solid material, and extract at a temperature of 68 °C and a pressure of 0.25 MPa under microwave pressure for 30 minutes, and then carry out solid-liquid separation after microwave extraction is completed. Extract, the extract is filtered and concentrated to obtain an extract wit...
Embodiment 3
[0036] A traditional Chinese medicine composition for treating septic myocardial injury, comprising the following raw materials in parts by weight: 23 parts of Zizhugen, 20 parts of philodendron, 18 parts of Zoumafeng, 15 parts of dendrobium, 15 parts of cat's eye grass, and 10 parts of mulberry , 8 parts of Jiaogulan, 8 parts of seabuckthorn, 10 parts of tea tree seeds, 5 parts of dandelion, 5 parts of Shanzi mushroom, and 3 parts of licorice.
[0037] The preparation method of the above-mentioned Chinese medicine composition for treating sepsis myocardial injury comprises the following steps:
[0038] (1) Take purple bamboo root and magma fruit, wash and chop, add water 7 times the weight of the solid material, and extract at a temperature of 70°C and a pressure of 0.3 MPa under microwave pressure for 30 minutes, and then carry out solid-liquid separation after microwave extraction is completed. Extract, the extract is filtered and concentrated to obtain an extract with a re...
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Abstract
The invention discloses a traditional Chinese medicine composition for treating septic myocardial injury, which comprises the following raw materials in parts by weight: 18-23 parts of purple bamboo root, 18-20 parts of camphor fruit, 15-18 parts of zoumafeng, and 10-15 parts of dendrobium 12‑15 parts of cat's eye grass, 5‑10 parts of mulberry seed, 5‑8 parts of Jiaogulan, 5‑8 parts of seabuckthorn, 5‑10 parts of tea tree seed, 1‑5 parts of dandelion, 1‑5 parts of Sanji mushroom. The traditional Chinese medicine composition provided by the present invention, with purple bamboo root and magma fruit as the monarch drug, promotes blood circulation and removes blood stasis; Zoumafeng, dendrobium, and cat's eye grass are ministerial drugs, dredge the meridian and activate collaterals, and cooperate with the monarch drug to help regulate Qi and blood; The seeds of mulberry, Gynostemma pentaphyllum, and Hippophae rhamnoides are used as adjuvant drugs, which can nourish qi and nourish yin, invigorate qi and blood, diuretic and reduce swelling; tea tree seeds, dandelion and Arrowhead mushroom are used as envoys, cooling blood and promoting blood circulation, clearing heat and detoxifying; licorice is used to reconcile Various medicines are introduced into the classics. The synergistic effect of each raw material within a limited range can improve heart function and inhibit inflammatory response. The invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition, which improves the extraction rate of active ingredients and better exerts the medicinal effect.
Description
technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating sepsis myocardial injury and a preparation method thereof. Background technique [0002] Sepsis is a life-threatening clinical syndrome caused by various infection-induced imbalances in the body's response. Severe burns, trauma, surgery, shock, etc. may lead to sepsis. In recent years, although great progress has been made in anti-infection therapy and organ function support therapy, research on pathophysiological mechanisms has been deepened, and new treatment concepts and methods have emerged, the mortality rate remains high. As the core organ of the body, the heart is also one of the most vulnerable organs in the course of sepsis. In sepsis, the body is stimulated by endotoxin to activate the monocyte-macrophage system to produce tumor necrosis factor-α, interleukin-1 and interleukin-6, causing systemic infla...
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