New application of traditional Chinese medicine composition

The technology of a composition and traditional Chinese medicine is applied in the new use field of traditional Chinese medicine composition, which can solve the problems of lack, lack of killing or inhibiting staphylococcus, etc., and achieve the effect of significant bacteriostatic effect.

Inactive Publication Date: 2020-08-28
BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, in view of the lack of antibacterial Chinese medicines for killing or inhibiting Staphylococcus in the prior art, especially the lack of Chinese medi

Method used

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  • New application of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation of Chinese medicine composition

[0046] Prescription: 10g astragalus, 10g vinegar Bupleurum, 10g turmeric, 10g Atractylodes macrocephala, 6g Fapinellia, 10g capillary, 10g Alisma, 10g cassia, 10g salvia, 8g angelica, 5g hawthorn and 9g white mustard seed.

[0047] The preparation of the traditional Chinese medicine liquid adopts the traditional water decoction method. Weigh a certain amount of Chinese medicinal materials according to the prescription, soak them in distilled water with 5 times the mass for 30 minutes, and collect the supernatant after boiling for 30 minutes. , and then boiled for 30 minutes to collect the supernatant, mixed two leachate to measure the pH value of 7, further decocted, concentrated to 2 g / ml of crude drug per milliliter, measured pH value of 7, centrifuged at 3000 rpm for 5 minutes, and took the supernatant Liquid high-pressure steam sterilization at 121°C for 15 minutes, and cool down for later use.

Embodiment 2

[0048] Embodiment 2: the preparation of Chinese medicine composition

[0049] Prescription: 15g astragalus, 15g vinegar Bupleurum, 15g turmeric, 15g Atractylodes macrocephala, 8g Fapinellia, 15g capillary, 15g Alisma, 15g cassia, 15g salvia, 10g angelica, 8g hawthorn and 10g white mustard seed.

[0050] The preparation of the traditional Chinese medicine liquid adopts the traditional water decoction method. Weigh a certain amount of Chinese medicinal materials according to the prescription, soak them in distilled water with 5 times the mass for 30 minutes, and collect the supernatant after boiling for 30 minutes. , and then boiled for 30 minutes to collect the supernatant, mixed two leachate to measure the pH value of 7, further decocted, concentrated to 2 g / ml of crude drug per milliliter, measured pH value of 7, centrifuged at 3000 rpm for 5 minutes, and took the supernatant Liquid high-pressure steam sterilization at 121°C for 15 minutes, and cool down for later use.

Embodiment 3

[0051] Embodiment 3: the preparation of Chinese medicine composition

[0052] Prescription: 12g Astragalus, 13g Vinegar Bupleurum, 12g Curcuma, 11g Atractylodes Rhizoma, 5g Fapinellia, 12g Capillary, 12g Alisma, 13g Cassia, 12g Salvia, 6g Angelica, 6g Hawthorn and 8g White Mustard Seed.

[0053] The preparation of the traditional Chinese medicine liquid adopts the traditional water decoction method. Weigh a certain amount of Chinese medicinal materials according to the prescription, soak them in distilled water with 5 times the mass for 30 minutes, and collect the supernatant after boiling for 30 minutes. , and then boiled for 30 minutes to collect the supernatant, mixed two leachate to measure the pH value of 7, further decocted, concentrated to 2 g / ml of crude drug per milliliter, measured pH value of 7, centrifuged at 3000 rpm for 5 minutes, and took the supernatant Liquid high-pressure steam sterilization at 121°C for 15 minutes, and cool down for later use.

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PUM

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparation of an antibacterial drug for killing or inhibiting staphylococcus. The traditional Chinese medicinecomposition comprises salvia miltiorrhiza. Bacteriostatic experiment researches find that the traditional Chinese medicine composition composed of radix astragali, salvia miltiorrhiza, radix bupleuri,herba artemisiae capillariae, radix curcumae aromae, rhizoma atractylodis macrocephalae, rhizoma pinelliae and the like has a bacteriostasis effect on g+ staphylococcus, especially has a substantialbacteriostasis effect on methicillin-resistant staphylococcus aureus, and provides possibility for clinical treatment of MRSA.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a new application of a traditional Chinese medicine composition. Background technique [0002] Staphylococcus is a group of Gram-positive cocci, so named because they often pile up into bunches of grapes. Most are non-pathogenic bacteria, a few can cause disease. Staphylococcus is the most common pyogenic coccus, which is an important source of hospital cross-infection. The diameter of the bacteria is about 0.8 μm, and it is small spherical. However, in the young culture of liquid medium, it is often dispersed and the bacterial cells exist alone. [0003] Staphylococcus aureus (SAU) is a common pathogen of clinical infection and widely distributed in nature. In the era of lack of effective antibacterial drugs, SAU infection poses a great threat to human health. After the advent of penicillin in the 1940s, the disease of SAU infection has been relatively well control...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K36/9066A61P31/04
CPCA61K36/232A61K36/233A61K36/282A61K36/284A61K36/31A61K36/481A61K36/482A61K36/537A61K36/734A61K36/884A61K36/8888A61K36/9066A61P31/04A61K2300/00
Inventor 张会存高翔汪红兵
Owner BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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