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Preparation method of compound SS-2 and application of schima superba extract

A technology of SS-2 and compound, which is applied in the field of extraction of Schima superba stem compound, can solve the problems of limited structure types, drug resistance of toxic and side effects, mechanism of action and single target, and achieve good antifungal effect

Inactive Publication Date: 2020-09-04
XIAMEN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the types of antifungal drugs in clinical use are limited (mainly polyene amphotericin B and its derivatives, azoles, echinocandins, nikkomycin, etc.), and the mechanism of action and target are relatively single , and these antifungal drugs have various side effects and increasingly severe drug resistance problems[13,14]

Method used

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  • Preparation method of compound SS-2 and application of schima superba extract
  • Preparation method of compound SS-2 and application of schima superba extract
  • Preparation method of compound SS-2 and application of schima superba extract

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Embodiment Construction

[0019] Extraction and separation process

[0020] Dry coarse powder 4.5kg of Schima superba stem, heat and reflux 3 times with 95% ethanol (8 times the amount of medicinal material), each time for 2 hours, combine the extracts for 3 times, and concentrate under reduced pressure to obtain 200g of total extract. The total extract was dissolved and dispersed with 50% methanol water, extracted with petroleum ether, chloroform, ethyl acetate and n-butanol in sequence to obtain 50 g of petroleum ether layer, 35 g of chloroform layer, 22 g of ethyl acetate layer and 20 g of n-butanol And the water layer 45g. The ethyl acetate fraction was subjected to silica gel column chromatography in a chloroform-methanol system (100:0; 90:10; 80:20; 70:30; 60:40; 50:50; 30:70; 0:100) to obtain Fr.1 -20 fractions. Wherein fraction Fr.15 (8.9g) is subjected to ODS reverse column chromatography (200g, 3.5cm x 40cm) water-methanol system (80:20; 70:30; 60:40; 40:60; 20:80; 0 :100) to obtain fracti...

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Abstract

The invention discloses a preparation method of a compound SS-2 and application of a schima superba extract, and the structure of the compound SS-2 is shown in the specification. The compound of the invention can be used for resisting fungus.

Description

technical field [0001] The invention relates to a method for extracting compounds from Schima superba stems. Background technique [0002] Fungal infection, especially deep fungal infection and fungal drug resistance, is a major problem facing human health and one of the main causes of human disease and death. In recent years, with the widespread use of immunosuppressants, the widespread development of tumor radiotherapy and chemotherapy, especially the increasing number of AIDS patients, the incidence of fungal infections, especially deep fungal infections, has increased sharply. Fungal infection has become one of the main causes of death in the above-mentioned immunocompromised critical disease patients. While antifungal drugs have been widely used clinically for a long time, the phenomenon of fungal drug resistance is becoming more and more common, and the degree of drug resistance is also increasing. Drug resistance has become the main reason for the failure of clinical...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/704A61P31/10A61K8/63A61K8/9789A61K36/82A61Q17/00
CPCA61K8/63A61K31/704A61K36/82A61K2800/805A61Q17/005A61K8/9789A61P31/10C07J63/008
Inventor 黄新翔吴春伊雪李津明廖佳若李君豪
Owner XIAMEN MEDICAL COLLEGE
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