Preparation method of compound SS-2 and application of schima superba extract
A technology of SS-2 and compound, which is applied in the field of extraction of Schima superba stem compound, can solve the problems of limited structure types, drug resistance of toxic and side effects, mechanism of action and single target, and achieve good antifungal effect
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[0019] Extraction and separation process
[0020] Dry coarse powder 4.5kg of Schima superba stem, heat and reflux 3 times with 95% ethanol (8 times the amount of medicinal material), each time for 2 hours, combine the extracts for 3 times, and concentrate under reduced pressure to obtain 200g of total extract. The total extract was dissolved and dispersed with 50% methanol water, extracted with petroleum ether, chloroform, ethyl acetate and n-butanol in sequence to obtain 50 g of petroleum ether layer, 35 g of chloroform layer, 22 g of ethyl acetate layer and 20 g of n-butanol And the water layer 45g. The ethyl acetate fraction was subjected to silica gel column chromatography in a chloroform-methanol system (100:0; 90:10; 80:20; 70:30; 60:40; 50:50; 30:70; 0:100) to obtain Fr.1 -20 fractions. Wherein fraction Fr.15 (8.9g) is subjected to ODS reverse column chromatography (200g, 3.5cm x 40cm) water-methanol system (80:20; 70:30; 60:40; 40:60; 20:80; 0 :100) to obtain fracti...
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