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A magnetic resonance imaging contrast agent and its preparation method and application

A magnetic resonance imaging and contrast agent technology, which is applied in the direction of pharmaceutical formulations, nanotechnology for sensing, preparations for in vivo experiments, etc., can solve the problems of ferric oxide particle residues, etc., to reduce the concentration of iron ions, Reduce adsorption and reduce tissue damage

Active Publication Date: 2018-08-03
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above defects or improvement needs of the prior art, the present invention provides a magnetic resonance imaging contrast agent and its preparation method and application. Technical problems of iron ferric oxide particles remaining in the body

Method used

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  • A magnetic resonance imaging contrast agent and its preparation method and application
  • A magnetic resonance imaging contrast agent and its preparation method and application
  • A magnetic resonance imaging contrast agent and its preparation method and application

Examples

Experimental program
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preparation example Construction

[0035] The preparation method of the above-mentioned contrast agent comprises the following steps:

[0036] (1) The raw material powder is prepared as a 0.04% to 0.2% aqueous solution, and the free iron ions and small molecular compounds are removed by methods such as tangential flow ultrafiltration or dialysis; the raw material powder includes a mass fraction of 6% to 12% iron ferric oxide particles, 0.6% to 1.2% citric acid and 86.8% to 93.4% hydroxyethyl starch, the particle size of the iron ferric oxide particles is 60nm to 75nm, and the citric acid coating on the surface of the ferric oxide particles;

[0037] (2) Assuming that the quality of D-polylysine is 6% to 20% of the mass of the ferric oxide particles, add 0.04% to 0.2 times the volume of the aqueous solution in the step (1) to 0.01 to 0.05 times. % D-polylysine solution, so that D-polylysine is completely dispersed in the solution evenly, and is bound to the surface of the citric acid through ionic bonds to obta...

Embodiment 1

[0047] Example 1 The preparation method of D-polylysine encapsulating nano-scale iron ferric oxide particles

[0048] (1) take by weighing raw material powder (which contains 9.2wt% superparamagnetic nano iron ferric oxide particles, 0.8wt% citric acid, 88.5% average molecular weight is the hydroxyethyl starch of 130KDa, other part is in the raw material powder impurity) solid 5 grams is dissolved in 5.0 liters of pure water, is placed in the storage container of tangential flow ultrafiltration device (Pellicon 2 device of Millipore Company), passes through ultrafiltration membrane block (the 5K molecular weight of Pellicon 2 of Millipore Company) fiber membrane) to carry out tangential flow ultrafiltration purification, the tangential flow velocity is set to the flow velocity (10 milliliters per minute) when the critical point of the tangential flow velocity linear pressure difference and saturation pressure difference, when the filter out container of the tangential flow filt...

Embodiment 2

[0053] Example 2 R-polylysine coated nano-scale ferric oxide lyophilized powder injection

[0054] After the liquid obtained in the step (2) of the above Example 1 is filtered through a 0.2 micron pore size filter, it is sub-packed in a glass bottle with a volume of 5 milliliters, and then freeze-dried in a vacuum. The powder obtained in the glass bottle is subjected to nitrogen gas Protected and sealed with a gland, that is, R-polylysine-coated nano-scale ferric oxide lyophilized powder injection. When using powder injection, inject 3.5 ml of clinical saline into the glass bottle, shake well and dissolve to prepare a solution. The recommended injection dose is 0.5 ml per 10 kg body weight.

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Abstract

The invention discloses a magnetic resonance imaging contrast agent, which comprises superparamagnetic nanoparticles and hydroxyethyl starch with a mass ratio of 1:5 to 1:15, and the particle diameter of the superparamagnetic nanoparticles is 100nm to 140nm. From the inside to the outside, it is composed of ferric oxide particles, citric acid and D-polylysine. The citric acid is adsorbed on the surface of the ferric oxide particles. acid, and the quality of the citric acid is 6% to 13% of the mass of the ferric oxide particles, and the quality of the D-polylysine is 8% to 13% of the mass of the ferric oxide particles. 20%, the magnetic resonance imaging contrast agent is a solution or a freeze-dried powder. The invention also discloses the preparation method and application of the magnetic resonance imaging contrast agent. The magnetic resonance imaging contrast agent prepared by the invention has a lower dose of cell uptake, thereby avoiding the damage of biological functions caused by iron overload.

Description

technical field [0001] The invention belongs to the field of magnetic resonance imaging contrast agents, and more specifically relates to a magnetic resonance imaging contrast agent and its preparation method and application. Background technique [0002] Superparamagnetic nanoscale Fe3O4 nanoparticles are a contrast-enhancing agent for magnetic resonance imaging and have been widely used in in vivo clinical diagnosis and prognosis of tumors. Superparamagnetic nano-scale ferric oxide nanoparticles are currently mainly used in the in vivo diagnosis of liver cancer. Liver cancer is a serious disease in China, with 350,000 new cases every year, and its fatality rate ranks second in China. It has been reported that the superparamagnetic nano-scale iron tetraoxide contrast agent can help the discovery of tumors smaller than 1 cm, so it will significantly improve the existing 5-year survival rate of liver cancer patients, which is only 10%. In recent years, superparamagnetic nano...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/12A61K49/18B82Y5/00B82Y15/00
CPCA61K49/126A61K49/1872B82Y5/00B82Y15/00A61K49/12A61K49/1863A61K49/18
Inventor 周琦冰魏裕双杨祥良
Owner HUAZHONG UNIV OF SCI & TECH
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