Application of roseolic acid C to preparation of medicine for preventing and/or treating epilepsy

A rose acid and epilepsy technology, applied in the field of medicine, can solve problems such as prolonging the depolarization time, and achieve the effect of reducing the level of epileptic seizures

Active Publication Date: 2020-09-15
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NMDA receptor channels by their nature allow prolonged Ca2+ influx and lead to prolonged depolarization

Method used

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  • Application of roseolic acid C to preparation of medicine for preventing and/or treating epilepsy
  • Application of roseolic acid C to preparation of medicine for preventing and/or treating epilepsy
  • Application of roseolic acid C to preparation of medicine for preventing and/or treating epilepsy

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Embodiment Construction

[0054] Hereinafter, the present invention is described in more detail to facilitate understanding of the present invention.

[0055] Effects of roseic acid C on pentylenetetrazol epilepsy model rats.

[0056] Epilepsy is characterized by paroxysmal abnormal discharge of neurons leading to sudden, repeated and transient central nervous system dysfunction. Increased neuron excitation and excessively synchronized discharge may be the basic conditions for epilepsy. The classic epileptogen PTZ ignition model is considered to be one of the ideal animal models for simulating human epilepsy. Intraperitoneal injection of PTZ or administration of cerebral cortex can induce animal epilepsy models, and PTZ itself has no special neurotoxic effect, so it is a common model for studying epileptic seizures and neuronal damage.

[0057] (1) Experimental process

[0058] 1. Experimental reagents and instruments

[0059] Pentylenetetrazol (PTZ) was purchased from Sigma Company of the United Stat...

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Abstract

The invention relates to an application of roseolic acid C or pharmaceutically acceptable salts or hydrates thereof of therapeutically effective amount to preparation of a medicine for preventing and / or treating epilepsy for a testee having requirements, wherein the roseolic acid C can restore abnormal EEG during status epilepticus, can reduce epileptic attack rate and attack level, can restrain activity of hippocampus excitatory neurotransmitter receptors NMDA, can agitate activity of hippocampus inhibiting neurotransmitter receptors GABA, reduce cerebral cortex excitability, further restrainepileptic formation and exert the epileptic resisting effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of roseic acid C in the preparation of drugs for treating epilepsy. Background technique [0002] Epilepsy is a chronic disease in which the sudden abnormal discharge of brain neurons leads to transient brain dysfunction. The status epilepticus (status epilepticus, SE) refers to the frequent occurrence of epileptic seizures in a short period of time, so that the consciousness persists in coma during the seizure period. The incidence of chronic encephalopathy, brain atrophy, and focal neurosis increased significantly after SE. Patients had typical neuronal necrosis and loss in the CA1 region of the hippocampus. However, the mechanism of brain injury has not yet been elucidated, and clinically effective treatments are also lacking. [0003] At present, there are more and more epileptic patients at home and abroad. Statistics show that epileptic patients account fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K45/06A61P25/08
CPCA61K31/19A61K45/06A61P25/08
Inventor 徐仁爱邵圆圆叶雪梅
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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