72 results about "Cortex cerebri" patented technology

Systems and methods for non-invasive management of head pain are disclosed. The system includes a headgear configured to be worn on a patient's head. The headgear can include a base and an extension coupled to the base, and a number of therapy devices removably or adjustably attached to the base or the extension. The therapy devices can deliver various modes of therapeutic energy at respective target sites on the head, including neuromodulation of peripheral pain pathways and / or the cerebral cortex, and therapy modalities to facilitate or enhance the neuromodulation effects. The system can include a portable device that enables the user to control the therapy devices on the headgear. The user can use the portable device to optionally access a web-based repository to acquire information about headgear usage from other users, and use that information to guide the programming of the therapy devices.

The invention discloses a method for preparing a memory-improving bioactive peptide from deep sea fish, which comprises the following steps: (1) carrying out restrictive enzymolysis; (2) separating proteins and lipids; (3) removing macromolecular proteins by ultrafiltration; (4) separating and purifying with ion exchange resin; and (5) concentrating, and carrying out spray drying to obtain the memory-improving peptide. The mouse step-down test and Japanese maze test on the memory-improving peptide prove that the peptide has obvious biological activity; and the cerebral cortex histological structure change shows that the peptide can obviously increase the types of mouse cerebral nerve cell synapses, thicken the synaptolemma, increase the synaptic vesicles, and increase and enlarge the mitochondrias, and also proves that the memory-improving peptide is very beneficial to growth and development of the cerebral cortex. The peptide can improve the hypomnesia of adults and promote intelligence development of minor children, and is hopeful to develop into clinical nutritional food for patients with senile dementia.

Provided are a cerebral cortex electrode and magnetic resonance image fusion display method and device. The method comprises: (S01) obtaining an MRI image through MRI scanning before a patent is implanted with an intracranial electrode and an implanted CT image through CT scanning after the patent is implanted with an intracranial electrode; (S02), registering the MRI image and the CT image in a same coordinate space; S03, extracting electrode image information in the registered CT image; S04, extracting cerebral cortex tissue image information from the registered MRI image; S05, performing special fusion on the electrode image information and the cerebral cortex tissue image information, and displaying the information after special fusion in a 3-dimension graphic method; and S06,adjusting the effect and angle of3-dimension graphic display, and converting an adjusted result into a required format for outputting and storing. According to the invention, electrode position information can be obtained.

A subarachnoid pharmacodialysis apparatus insertable under the scalp, in and under the cranium, with a relatively short and simple neurosurgical procedure, to be kept there safely implanted for a year or longer for the purpose of regulating the neurochemistry of one or more diseased cerebral cortical areas and thus to achieve therapeutic effects via both localized delivery of medication and drainage of local neurotoxic molecules across the subdural meninges and compartments in a feedback-controlled fashion, with or without the additional capability of performing localized neurochemistry regulation in subcortical areas. This apparatus is also used for neurochemical profiling of the diseased brain area or areas by analyzing the removed endogenous molecules and adjusting the composition of the delivered medication based on the patient's specific, abnormal neurochemistry within the treated area or areas.

The invention provides a method for removing psychological disorder for a patient by the virtual technology. The working principle of the method is that a virtual user graph or image is obtained, a virtual user exposes in a virtual reality scene, an electrical-wave signal is acquired from the cerebral cortex of the user as the indirect measurement of the psychological rehabilitation effect; the real scene is changed to induce electric wave of the cerebral cortex of the user to enable the electric wave of the cerebral cortex to enter some state; active suggestions are provided to the user according to the special medical service of psychological rehabilitation for the user, so as to enable the electric wave of the cerebral cortex to be kept in the state all the time, and therefore, the active experience result of the user is improved, and a good way is provided for psychological training and rehabilitation; meanwhile, the motion sensing technology is performed to bring the user the realistic sensation, and thus the user can learn the way to treat a disaster in emergency while accepting psychological rehabilitation.

The invention provides an application of dicaffeoylquinic acid for the preparation of drugs of cerebral neuroprotection and the drugs can be used for curing ischemic strokes. The invention also provides a drug composite of cerebral neuroprotection. Drug effect tests and researches show that dicaffeoylquinic acid component is a new kind of effective ingredients which can protect cerebral nerve better, can both promote the survival of cerebral cortical neurons in vitro and the antioxidation and has a certain function of passing blood-brain barrier.

The invention provides an analysis method for electroencephalogram signals of children with autism spectrum disorder. The method comprises the following steps: step 1, collecting resting-state electroencephalogram signals by using a multi-lead electroencephalogram system; step 2, preprocessing obtained image data; step 3, calculating source activity of intracranial cerebral cortex based on electroencephalogram signals recorded by scalp electrodes by adopting an accurate low-resolution electroencephalogram tomography technology so as to obtain current density time sequences of 84 ROI regions; step 4, performing spatial-temporal feature analysis on the current density time sequences of each subject, each frequency band and each ROI to obtain spatial-temporal characteristic parameters beta; and step 5, detecting whether the spatial-temporal characteristic parameters beta of tested children with autism spectrum disorder and tested normal children have significant inter-group difference ornot. According to the analysis method for the electroencephalogram signals of the children with the autism spectrum disorder, electroencephalogram spatial-temporal characteristic parameters which facilitate the diagnosis of the children with the autism spectrum disorder can be obtained, and medical workers are assisted in completing preliminary diagnosis of the children with the autism spectrum disorder.

The invention discloses a near-infrared-based multi-band physiological signal feedback system and a using method thereof. The system comprises a physiological signal acquisition module used for acquiring cerebral blood oxygen signals of cerebral cortex of a subject in real time; a data preprocessing module which is used for preprocessing the original data acquired by near infrared spectrum equipment in real time so as to remove noise components in the signals; a multi-band analysis module which is used for extracting multi-band physiological signal intensity index parameters from the preprocessed cerebral blood oxygen signals; a physiological signal feedback module which is used for performing real-time data visualization processing on the intensity index parameters extracted by the multi-band analysis module and feeding back the processed intensity index parameters to the subject; and a display module which is used for displaying the feedback process of the physiological signal feedback module. Based on the near infrared spectrum technology, the physiological activity and nerve activity of the brain in the specific frequency band are adjusted through a five-frequency-band physiological signal feedback method, and the brain dysfunction patient is helped to be trained and rehabilitated better.

The invention provides a preparation method of neural stem cells and glutamatergic neurons in cerebral cortex, and relates to an iPSC complete neural induction culture medium. The iPSC complete neuralinduction culture medium comprises the following components: a cell basic culture medium, a cell culture additive, neural development factors and an inhibitor. The invention provides the iPSC complete neural induction culture medium, an iPSC nerve cell culture medium and a culture method. The culture medium includes a serum-free basic medium, a cell additive, neural development factors and an inhibitor. The use of the serum-free basic medium can avoid the introduction of exogenous substances and reduce the risk of pollution. Meanwhile, a variety of nutrients, such as the cell additive and theneural development factors, can enable iPSC cells to be stimulated by signals so that iPSC cells can be activated to promote differentiation. The cell culture method provided by the invention is simple, efficient, low in cost, and can induce high-quality neuron cells in a short period.

The present invention relates to single nucleotide polymorphism (SNP) which can be used for Alzheimer's disease risk prediction. The SNP is rs405509 and is located on chromosome 19, 44905579 on the basis of human genome map GRCh38.p7. The present invention suggests that T allele of rs405509 plays the role of further increasing the risk of dementia of APOE E4 / E4. The result of cerebral cortical thickness and hippocampal volume comparison between APOE genotypes suggests that the contraction of E4 / E4 is greater than E3 / E3 in Asians. The cerebral cortex of people having rs405509 T / T genotype among Caucasians having E4 / E4 genotype is more severely atrophied. Therefore, the present invention enables confirmation of rs405509 T / T polymorphism along with APOE E4 / E4 and thus can be used for diagnosing or risk-predicting Alzheimer's disease and / or dementia due to Alzheimer's disease.

The invention discloses the application of forsythiaside in preparing medicine promoting nerve cell proliferation and protecting nerve cells; the application of forsythiaside in preparing medicine improving passive avoidance response and impaired spatial learning and memory and enhancing learning and memory; the application of forsythiaside in preparing medicine increasing the total protein content in cerebral cortex tissue; the application of forsythiaside in preparing medicine reducing the activity of acetylcholin esterase in cerebral cortex and hippocampus brain tissue; the application of forsythiaside in preparing medicine improving the activity of superoxide dismutase in cerebral cortex and hippocampus brain tissue, and reducing the malonaldehyde content and the monoamine oxidase activity in cerebral cortex and hippocampus brain tissue; the application of forsythiaside in preparing medicine reducing the content of inflammatory factor TNF-alpha and IL-6 in the brain tissue of cerebral cortex; and the application of forsythiaside in preparing medicine treating mild cognitive impairment, especially senile dementia.

The present invention discloses an electrical stimulation method for observing rat craniotomy motor cortex with the adjustable waveform and amplitude. The method is characterized in that: the motor area of the cerebral cortex is an advanced nerve center for regulating the body motor function, and, through the downward pathway of the pyramidal and extrapyramidal system, controls activities of the brain stem and spinal motor neurons, so as to control muscle movement. Corresponding effects occur after cortical electrical stimulation, experimenters attempt to, through the electrical stimulation of the motor area of the cerebral cortex, cause the effect of body movement, and observe the phenomenon of functional localization of the motor area of the cortex. The rat is fixed to a stereotaxic apparatus, the bone windows are opened, a cortical electrical stimulation using microelectrode is performed, and the electrode is inserted vertically into the position 1.8 mm below the cortex, and adjusted within a range of + / - 200 um so as to cause the maximum movement of the contralateral forelimb, facial hair and neck corresponding to the stimulation points. An electrical stimulator with the adjustable waveform and amplitude is further produced, is capable of accurately completing the experimental observation of electrical stimulation predetermined by experimenters, and provides technical support for the experiment.

The invention relates to a stereotactic magnetic head, an array, and a brain neuronal electrical activity interference system. The technical characteristics are that the stereotactic magnetic head comprises a stereotactic magnetic head shell, a pulse magnetic field coil, a pulse magnetic field guide column, a plurality of magnetic field stereotactic control coils and a magnetic field guide conical ring; the stereoscopic magnetic head array consists of a plurality of stereoscopic magnetic heads; and the system comprises a stereotactic magnetic head array, a pulse magnetic field coil control unit, a magnetic field stereotactic control coil control unit and a central control unit. According to the invention, the membrane potential of the cerebral cortical nerve cells can be changed and an induced current can be produced by applying the pulse magnetic field to the brain; the control function of the electrical activity of the cerebral cortical nerve cells can be realized by controlling the direction of the pulse magnetic field and the magnetic induction intensity; and the invention can be widely used in noninvasive artificial vision, artificial hearing, control treatment of abnormal cerebral cortex electrical activity and abnormal neuronal reshaping and the like.

The invention belongs to the field of cell biology and relates to a method and reagent for the separation and culture of neurons. The method and the reagent are used for solving problems in the prior art, the current in-vitro hippocampal neuron separation and culture methods are improved, and the problem that the proliferation and activity of cortex nerve cells during primary culture can not be maintained is solved. According to the method and the reagent, a relatively mature in-vitro cortex nerve cell culture method is established, the number of obtained nerve cells is sufficient, the growth status is relatively good, and a large number of high-activity cortex nerve cells can be separated from mammalian hippocampal tissue, so that the requirements for the primary culture of the cortex nerve cells are met, and the demands on experiments of cell biology during neuroscience research can be met.

The invention discloses a rehabilitation monitoring system and method based on near-infrared brain imaging, and the system comprises a near-infrared brain imaging collection module which is used for collecting a brain blood oxygen signal, analyzing an activation region of the cerebral cortex of a trainee, and monitoring the motion characteristics of muscle groups in a motion region of the cerebral cortex; the near-infrared peripheral nerve monitoring module is used for distinguishing nerves of each link and monitoring the activity of peripheral nerves of the nerves of each link; the muscle activity detection module is used for judging the activity degree of the muscle according to the blood oxygen content of the muscle; and the data processing and analyzing module is used for summarizing and analyzing the data, identifying weak muscle groups of the spine and monitoring the motion state of core muscle groups in real time. The brain function imaging dynamic spectrum during movement is combined, cerebral cortex activity information characteristics corresponding to movement are refined, muscle group activity is accurately monitored and evaluated, a specific cerebral cortex area is monitored so as to evaluate the brain activation degree, the muscle activation degree, the muscle fatigue degree and the like, and real-time monitoring of rehabilitation training is achieved.

The invention discloses a quantitative evaluation method for a two-way coupling information conduction path of a human body, relates to a set of multi-sensor fusion system, and is particularly provided for nervous system disease patients with motion symptoms. A two-way coupling information conduction path for connecting internal physiological electricity and external behavioral performance exists in a human body is an electroencephalogram-myoelectricity-action downlink control information conduction path and an action-myoelectricity-electroencephalogram uplink feedback information conduction path. According to the invention, information of three key nodes of brain, muscle and action in the two-way information conduction path is monitored at the same time, so on the one hand, doctors are assisted to carry out comprehensive and accurate quantitative evaluation on patient symptoms; on the other hand, neurogenic localization is carried out through cerebral cortex-muscle connectivity analysis, and then a personalized treatment scheme is customized for a patient.

A method of an in vitro screening for a ligand using two assay systems i.e. in a first cellular or tissue assay system, selecting the ligand with transcriptional ER-mediated activity measured by an ER-driven reporter gene, whereby in the first assay system the ligand activates the potency with an EC50(ER) (half-maximally effective ligand concentration) lower than to 10 nmol / l, and, in a second enzymatic assay system, selecting the physical-chemical interaction (recruitment) of SRC-1, wherein the ligand activates the ER and induces interaction with the co-present SRC-1 with an EC50(ER+SRC) higher than to 100 nmol / l. The ligands found by the inventive screening can be used for the treatment and prevention of neuro-degeneration in the cerebral cortex and are thus useful for treatment and prevention of age-related cognitive disorders, affective disorders, Alzheimer's diseases and cerebral ischemia / stroke.

The invention discloses lactobacillus rhamnosus CCFM1228 with functions of relieving depressive mood and promoting intestinal tract to secrete IgA and application of the lactobacillus rhamnosus CCFM1228, and belongs to the technical field of microorganisms. The lactobacillus rhamnosus can relieve depression-like behaviors of depressive mice, increase the content of neurotransmitter 5-hydroxytryptamine in the brain and increase the BDNF level in hippocampus of the depressive mice, and the lactobacillus rhamnosus CCFM1228 has the functions of relieving depressive mood and promoting intestinal tract to secrete IgA. The expression of hypothalamus Crh mRNA is inhibited, the level of corticosterone in serum is reduced, the activity of xanthine oxidase in cerebral cortex is reduced, the activity of adenosine deaminase in liver is improved, and the content of uric acid in serum is reduced; the prefrontal lobe Mbp mRNA level is improved, and the stability of the CNS myelin sheath structure and function is maintained; the mRNA level of the prefrontal lobe Gfap is improved, and the function of astrocytes is enhanced; the mRNA level of hippocampus CD36 is reduced, and immune homeostasis is regulated; the level of IgA in host feces can be improved on the basis of relieving the depression mood, and wide application prospects are achieved.

The invention provides a preparation method of neural stem cells and glutamatergic neurons in cerebral cortex, and relates to an iPSC complete neural induction culture medium. The iPSC complete neuralinduction culture medium comprises the following components: a cell basic culture medium, a cell culture additive, neural development factors and an inhibitor. The invention provides the iPSC complete neural induction culture medium, an iPSC nerve cell culture medium and a culture method. The culture medium includes a serum-free basic medium, a cell additive, neural development factors and an inhibitor. The use of the serum-free basic medium can avoid the introduction of exogenous substances and reduce the risk of pollution. Meanwhile, a variety of nutrients, such as the cell additive and theneural development factors, can enable iPSC cells to be stimulated by signals so that iPSC cells can be activated to promote differentiation. The cell culture method provided by the invention is simple, efficient, low in cost, and can induce high-quality neuron cells in a short period.

The present invention enables efficient suspension culture of stem cells in a serum-free medium by comprising a step for quickly forming a homogenous aggregate of stem cells, and provides a method of selectively inducing the differentiation of nerves from a stem cell, a method of forming a cerebral cortical nerve network in vitro, and a method of producing a steric structure of a brain tissue in vitro, as well as a method of producing hypothalamic neuron progenitor cells, comprising culturing pluripotent stem cells as a suspended aggregate in a serum-free medium that substantially does not contain a Nodal signal promoter, a Wnt signal promoter, an FGF signal promoter, a BMP signal promoter, retinoic acid and an insulin, and isolating hypothalamic neuron progenitor cells from the culture.

A cranial implant for access to a cerebral cortex includes a window member shaped and dimensioned for positioning within a dural defect to provide access through the dura such that access to the cerebral cortex is provided in a location under study. An implant body is provided having a geometry that substantially conforms to a resected portion of a patient's anatomy to which the implant body is to be secured.

An apparatus and method of use for a comprehensive transcranial low-level light therapy for use with ischemic brain tissue using a multitude of polychromatic Light Emitting Diodes (LEDs) embedded into a flexible head covering that stretches securely around the patient's cranium to bath the entire cranium cavity in a variable frequency, variable power density light spectrum, maximizing all beneficial effects to the cellular tissues whether or not they are specifically deprived of blood from the ischemic stroke event. The bulbs covering the n-p junction of the semiconductor LEDs directly contact the patient's cranial skin to maximize the depth of penetration of the wavelengths into the brain's cortex cells. By using many individual point-source LEDs emitting all around the cranium, greater therapeutic benefit can be achieved as more of the cortex tissues are irradiated.

The invention relates to an application of roseolic acid C or pharmaceutically acceptable salts or hydrates thereof of therapeutically effective amount to preparation of a medicine for preventing and / or treating epilepsy for a testee having requirements, wherein the roseolic acid C can restore abnormal EEG during status epilepticus, can reduce epileptic attack rate and attack level, can restrain activity of hippocampus excitatory neurotransmitter receptors NMDA, can agitate activity of hippocampus inhibiting neurotransmitter receptors GABA, reduce cerebral cortex excitability, further restrainepileptic formation and exert the epileptic resisting effect.

Methods for delivering a therapeutic agent to a cerebral cortex or to the cerebral cortex and spinal cord include administering a viral vector that includes the therapeutic agent into white matter of a brain in order to deliver the therapeutic agent to the cerebral cortex or to the cerebral cortex and spinal cord. Kits for performing such methods may include at least one viral vector, at least one therapeutic agent, and a convection enhanced delivery (CED) catheter.

Provided is a method for producing cerebral cortex neurons from pluripotent stem cells.Provided is a method for producing cerebral cortex neurons from pluripotent stem cells, comprising (i) a step of performing a suspension culture of pluripotent stem cells in a culture medium containing a TGFβ inhibitor, bFGF, a Wnt inhibitor, and a BMP inhibitor, (ii) a step of performing a suspension culture of the cells obtained in the step (i) in a culture medium containing a Wnt inhibitor and a BMP inhibitor, and (iii) a step of further culturing the cells obtained in the step (ii).

The embodiment of the invention discloses equipment for stimulating cerebral cortex to improve brain functions by using transcranial direct current. The equipment comprises direct current electrodes for stimulating a specific point in a cerebral cortex functional area and a control circuit for controlling stimulation current on the direct current electrode. Each direct current electrode is connected with an output interface of the control circuit. The control circuit outputs stimulation current polarity, stimulation current intensity, stimulation duration and stimulation sequence preset according to the state of a patient to perform fixed-point direct-current stimulation on the cerebral cortex functional area of the human body. The biological activity of cerebral cortex is adjusted, and the effect of improving brain functions is achieved.

Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.

The invention discloses catalpol nasal drops and a preparation method and application thereof.The catalpol nasal drops are prepared from catalpol, a thickening agent, an absorption enhancer and a pH regulator, the catalpol, the thickening agent and the absorption enhancer are 10 mg / ml, the mass percentage of the thickening agent is 0.1%, the volume percentage of the absorption enhancer is 2.0%, and the pH value is 6.5-7.0; the preparation is stable in storage property under normal-temperature and dark conditions; the absorption is fast through nasal administration, the concentration in brain tissues is obviously higher than that of intravenous administration, and brain targeting is achieved; compared with oral administration and injection administration, the catalpol nasal administration dosage form can also reduce the infarct volume of brain tissues of acute cerebral ischemia patients, and can reduce the number of apoptosis of neuronal cells in a cortical region caused by cerebral ischemia injury, which shows that the catalpol nasal administration dosage form has a remarkable neuroprotective effect on the cerebral cortical region; the catalpol nasal drops have low toxicity to cilia, no obvious nasal cavity irritation is found, and the nasal administration safety is good.