23 results about "Cortex cerebri" patented technology

The invention relates to the technical field of medical monitoring and early warning, and discloses a postoperative care risk early warning system for neurosurgical patients. According to the system, real-time monitoring flows of electroencephalogram, intracranial pressure and body surface myoelectricity of a patient are continuously received, and a dynamic interaction network of neuroelectrophysiology and intracranial mechanical states is constructed so as to represent the coupling relation among electroencephalogram rhythm, pressure conduction and postoperative skull windowing area tissue compliance. The system analyzes three types of core parameters of cerebral cortex excitability, cerebrospinal fluid circulation load and cranial cavity compensation space from the network, further calculates a brain tissue perfusion risk and a neural structure compression risk, and generates a corresponding nursing early warning signal and a physiological regulation path. According to the scheme, deep coupling and mechanism risk early warning of multiple physiological signals are achieved, and the postoperative complication risk can be recognized earlier and more accurately.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The application provides a wearable portable hairband for mental fatigue detection and intervention, a flexible conductive polymer dry electrode is embedded in the inner side of the hairband, the dry electrode is attached to the scalp through mechanical pressure, and thus inductive collection is realized without conductive paste; the output end of the dry electrode collection signal is directly connected to a collection front end located at the side edge of the hairband through FPC, the front end is integrated with an amplifier and an analog-to-digital converter, weak electrical signals on the cerebral cortex are amplified and converted into a data format; a SoC chip is selected as a processor to build a full-integrated edge computing platform inside the flexible fabric hairband, and the calculation task of mental fatigue detection is sunk to the hairband end; an ultrathin bone conduction unit is used as an acoustic output component, which is connected through a flexible circuit and embedded in the inner side of the hairband corresponding to the anatomical site of the user's temple, when the mental fatigue detection result triggers the fatigue warning threshold, a binaural rhythm intervention module is activated to perform binaural rhythm intervention. The application can perform mental fatigue detection and intervention.

The invention relates to a target spot optimization method and device and a storage medium, and the method comprises the steps: firstly obtaining the head modeling data, brain function partition, intervention process information and intervention curative effect information of a modeling object, then carrying out the calculation of a cerebral cortex induced electric field in an intervention process based on the head modeling data corresponding to the modeling object, and carrying out the calculation of a cerebral cortex induced electric field. Obtaining accumulated cerebral cortex induced electric field distribution in the intervention process, obtaining an induced electric field function connection matrix according to the accumulated cerebral cortex induced electric field distribution and the brain function partition, and finally establishing a target optimization model by utilizing the data of the induced electric field function connection matrix in combination with the intervention curative effect information. By more accurately determining the stimulation pose and parameters, accurate feedback of individual differences of application objects is realized, so that the overall curative effect of intervention is improved.

The present application relates to the technical field of pattern recognition, in particular to a stroke rehabilitation evaluation method based on brain muscle function network features, comprising the following steps: S1, collecting electroencephalogram signals and electromyogram signals, collecting electroencephalogram signals and electromyogram signals of a stroke patient under a hand dynamometer test; S2, respectively pre-processing the electroencephalogram signals and electromyogram signals; S3, constructing a variational mode decomposition transfer entropy; S4, constructing a CMFN model based on EEG and EMG; S5, brain muscle function network analysis. The method considers that the research on motor recovery of stroke stays in analyzing the consistency or coupling relationship changes between the cerebral cortex and the muscle, realizes the quantification of stroke evaluation, and greatly improves the evaluation accuracy.

A method and a system for fully automatically segmenting a cerebral cortex surface based on a graph network, the method including: registering a cerebral magnetic resonance image to a standard template space; performing cerebral cortex surface reconstruction on the registered cerebral magnetic resonance image based on a deep neural network; calculating adjacency matrices among the vertexes of the reconstructed cerebral cortex; acquiring corresponding distinguishing features of each grid vertex of the cerebral cortex surface as corresponding feature vectors of the point so as to obtain a cerebral cortex surface segmentation result; and mapping the cerebral cortex surface segmentation result back to the original coordinate space from the standard template space. Graph structure modeling is performed on the reconstructed cerebral cortex surface, and the global topological structure features are learned based on the graph network, thus realizing the accurate segmentation of the cerebral cortex surface.

Abnormal activity in the brain can be detected by identifying changes in tissue excitability measured in response to stimulation of fiber tracts such as the corpus callosum. A stimulating electrode contact can apply a stimulation to the fiber tract, which can have one or more terminals to a cortex of a patient's brain, and a recording electrode contact positioned in the fiber tract and / or the cortex to record a tissue excitability response to the stimulation. A controller can receive the tissue excitability response from the at least one recording electrode, identify a parameter of the tissue excitability response, and predict the abnormal activity in the patient's brain based on the parameter being different from a baseline for the parameter. When an abnormal activity is predicted the patient can be alerted to start a therapy and / or a therapy can be applied in closed loop manner by a connected therapy device.

The application provides a full hydrogel nerve electrode which is composed of four layers of hydrogel, namely a PSFD hydrogel layer, an LPPDMEA layer, a PSFD hydrogel layer and an MHD layer; the application also provides a preparation method and application of the full hydrogel nerve electrode. The application provides a PEDOT:PSS hydrogel conductive path with ultrahigh conductivity, which achieves a record capacity compared with a metal electrode; the introduction of dopamine in each layer of the full hydrogel nerve electrode ensures excellent interface compliance, so that the full hydrogel nerve electrode can be attached to the complex geometry of soft neural tissue and avoid interface mismatch between the conductive layer, the packaging layer, the shielding layer and the tissue-electrode interface; the natural polymer packaging layer improves compatibility, and the electromagnetic shielding layer is used to improve the signal-to-noise ratio. The full hydrogel nerve electrode can provide artificial electrical stimulation to the cerebral cortex of a rat during a seizure, and the prepared full hydrogel nerve electrode has the potential to become a valuable tool for better understanding the development, function and treatment of brain diseases and neurodegenerative diseases and neurodegenerative diseases.

The invention discloses application of an Islr gene in preparation of drugs for spinal cord injury repair. A transcriptome sequencing result of early spinal cord injury shows that the expression of the Islr gene after spinal cord injury is gradually increased; meanwhile, the expression of Islr is gradually increased in cerebral cortical neurons (the regeneration capacity is gradually weakened) in 1 day (P1) and 3 days (P3) after the rat is cultured in vitro for E18 days, so that the Islr gene is deduced to have an effect on diagnosis and treatment of spinal cord injury. E14-day spinal cord neurons subjected to primary culture are transfected through siRNA, and it is further verified that growth of neuronal axons can be promoted by inhibiting expression of Islr, and the effect on repairing spinal cord injuries is achieved.

This invention discloses a method for segmenting cerebral blood vessels in non-angiographic images, comprising the following steps: S1, inputting the original image A, i.e., the original non-angiographic image; S2, filtering out air, outputting image B; S3, dissecting the skull, outputting image C; S4, performing preliminary ablation of the cerebral cortex, outputting image D; S5, iteratively ablating the cerebral cortex, outputting image E, i.e., the final cerebral blood vessel image. This invention can dissect the skull and iteratively ablate the cerebral cortex without affecting the vascular components, thereby obtaining the purest and most complete cerebral blood vessel components possible.

The invention relates to a transcranial ultrasonic nerve regulation and control device and a control method. The transcranial ultrasonic nerve regulation and control device comprises an ultrasonic generation unit, ultrasonic waves are controllably provided to an intracranial target area, and the ultrasonic generation unit is configured to provide the ultrasonic waves with the frequency ranging from 3.0 MHz to 8.0 MHz to the intracranial target area. According to the transcranial ultrasonic nerve regulation device and the control method, the intracranial nerves are stimulated through the high-frequency ultrasonic waves with the working frequency of 3.0-8.0 MHz, the transcranial ultrasonic nerve regulation device and the control method have remarkable advantages in cortex regulation, energy is more easily absorbed by superficial tissue, the stimulated area covers the cerebral cortex and superficial white matter, and interference of a non-targeted deep structure is avoided. Meanwhile, the spatial resolution of the ultrasound of the frequency band can reach the submillimeter level, the ultrasound can be accurately focused on a tiny functional subregion, and the ultrasound is particularly suitable for nerve regulation scenes needing accurate positioning intervention and is suitable for nerve regulation of focal epilepsy, chronic pain syndromes, visual and auditory cortex dysfunction and mental and psychological disorders.

Methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain are provided. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.

The invention discloses a cinnabar nano-vesicle gel emplastrum with a tranquilizing and calming effect as well as a preparation method and application of the cinnabar nano-vesicle gel emplastrum. The method comprises the following steps: preparing target peptide modified cinnabar nano-vesicles by adopting a film dispersion method; dissolving cinnabar nano-vesicles in PBS as a phase C for later use; mixing the second framework material, the tackifier, the filler and the humectant to obtain a phase A; mixing a cross-linking agent, a cross-linking regulator, a penetration enhancer and a bacteriostatic agent to obtain a phase B; stirring and mixing the phase A, the phase B and the phase C, coating a non-woven fabric with the mixture, placing the non-woven fabric at room temperature, and covering the non-woven fabric with an anti-sticking film to obtain the target peptide modified cinnabar nano-vesicle gel emplastrum. The cinnabar nano-vesicle gel emplastrum can promote intestinal microorganisms to generate 5-hydroxytryptamine (5-HT), so that a cerebral cortex 5-HT1AR-cAMP pathway is activated, brain activity is adjusted, sleep conditions are improved, the cinnabar nano-vesicle gel emplastrum has slow release property, skin penetrability and intestinal tract targeting property, and the insecurity caused by direct oral administration of cinnabar into blood circulation is also solved.

A method of rapid constructing human cerebral cortical organoids by 3D bioprinting and an application including preparing microfluidic chips, preparation of hydrogel of human cerebral cortical organoids, and printing of human cerebral cortical organoids. The microfluidic chip comprises a mixed-flow channel layer, liquid pool layer, microporous array layer, human cerebral cortical organoid culture layer, and culture medium recovery layer; the human cerebral cortical organoid hydrogel has gelatin, alginate, and hyaluronic acid; printing directly human cerebral cortical organoids in microfluidic chips by FRESH printing method, obtaining human cerebral cortical organoid chips after packaging. The application directly constructs large-scale human cerebral cortex-like with three layers of mutually connected structures in situ in organ chip through 3D bioprinting, simulates cerebrospinal fluid circulation through perfusion culture.

This application discloses the application of Bcl11a in the preparation of drugs for nerve injury repair, belonging to the field of biomedical technology. The nerve injury is a central nervous system injury. Overexpression of Bcl11a promotes the transdifferentiation of an intermediate state astrocyte in the cerebral cortex into pyramidal neurons. Using Bcl11a as a molecular intervention target, targeting the M1 motor area of ​​the cerebral cortex, overexpression of Bcl11a in astrocyte subset 2 promotes the reprogramming of astrocytes into pyramidal neurons, promoting the repair of central nervous system injury. Using spatial transcriptome sequencing technology and single-cell sequencing technology, the dynamic trajectory between astrocytes and pyramidal cells was depicted, supporting the transformation of an intermediate transitional state astrocyte in the cortex into pyramidal cell subset 3 after spinal cord injury, indicating that Bcl11a and Zmart4 are key transcription factors in the connection between pyramidal cells and glial cells.

The invention relates to an intelligent mind and pupil monitoring method and device, and the method comprises the steps: collecting a brain heat radiation signal, a micro-motion feature and a pupil video sequence of a patient, and obtaining the cerebral cortex neural activity data of the patient; inputting the pupil video sequence into a deformed pupil positioning model, and extracting a pupil contour, a pupil diameter, a light reflex incubation period and a contraction speed curve; inputting the brain heat radiation signal, the micro-motion characteristic and the cerebral cortex neural activity data into a time-frequency fusion neural network model, and identifying the consciousness state of the patient; according to the pupil contour, the pupil diameter, the light reflex incubation period, the contraction speed curve and the consciousness state of the patient, a comprehensive neural state index report of the patient is generated. According to the method, sub-pixel-level pupil contour segmentation is achieved, the pupil diameter is accurately extracted, the method has higher adaptability to light reflection latency and contraction speed curves, pupil deformation, shielding and illumination changes, and finer changes of the consciousness state can be captured.

The invention provides an in-vitro cerebral cortex intermediate neuron precursor cell population as well as a preparation method and application of the in-vitro cerebral cortex intermediate neuron precursor cell population. According to the cell population, the iNSC is taken as an initial cell to directionally differentiate to the neuroectoderm cell, so that neuroendoderm and neuromesoderm impurity cells generated in the differentiation process can be reduced, the cell differentiation direction is more accurate, and the differentiated cell purity is higher. The cell population can be used for the prevention, diagnosis and treatment of nervous system diseases.

The invention discloses an individualized wearable transcranial magnetic stimulation treatment assisted positioning method, which comprises the following steps: based on T1 weighted structure imaging, obtaining a scalp surface, a skull surface and a cerebral cortex surface consistent with an individual head anatomy through surface reconstruction; on the basis of resting state functional magnetic resonance imaging, whole brain function connection analysis is executed to obtain an individualized cortex target spot; identifying anatomical mark points on the scalp surface and constructing a scalp curved surface coordinate system, and projecting the individualized cortex target spot from the cerebral cortex surface to the scalp surface to obtain an individualized scalp target spot position; selecting a scalp curved surface above an ear plane in the scalp curved surface coordinate system as a hood base area, making a three-dimensional model of the individualized positioning hood, and reserving a coil placement area corresponding to the individualized scalp target according to the position of the individualized scalp target; an individualized positioning hood entity is manufactured according to the three-dimensional model, and individualized accurate positioning, repeated placement and standardized operation of transcranial magnetic stimulation are achieved.

The invention discloses a method for researching an influence mechanism of TBMT on upper limb recovery of a stroke patient, and relates to the technical field of neurological rehabilitation and biomedical engineering. The system is realized based on a multi-modal evaluation system, and the system comprises a task-oriented mirror image therapeutic instrument which is used for guiding a patient to carry out specific hand task training; the near infrared spectrum detection module is used for collecting blood oxygen signals of the cerebral cortex of the patient in a resting state and a task state so as to evaluate the brain function connection strength and the brain region activation level; and the surface electromyographic signal acquisition module is used for acquiring electromyographic signals of related muscles when the patient executes the grasping action. The TBMT is deeply combined with the resting state / task state of the fNIRS and the sEMG, and the biological basis of the curative effect of the TBMT is clearly and objectively revealed from two dimensions of central nervous remodeling and peripheral function output; quantitative physiological signals are used for replacing or supplementing a subjective scale, so that curative effect evaluation is more accurate and sensitive, and early-stage and subtle rehabilitation progress can be found.

The invention relates to application of KLF4 as a target spot in APOE4 genotype Alzheimer disease, and belongs to the technical field of biological medicine. The invention provides an application of KLF4 in preparation of any one of the following medicines: (1) improving learning and memory ability impairment; (2) the blood-brain barrier function is improved; and (3) treating or preventing neurodegenerative diseases. According to the application disclosed by the invention, the expression of KLF4 in cerebral cortex of APOE4 genotype patients and mice is obviously reduced, the KLF4 in APOE4 mice is obviously lower than that in APOE3 mice, and the cortex expression of APOE4 carriers is lower than that of non-carriers. According to the application disclosed by the invention, in-depth research by taking the KLF4 as an entry point finds that the APOE4 reduces the expression of the KLF4 and destroys a BBB structure, so that learning and memory impairment is caused, and then the APOE4 develops into neurodegenerative diseases, and the symptoms can be improved by overexpression of the KLF4.

The invention provides a heterocyclic ring substituted pyrazine derivative. The heterocyclic substituted pyrazine derivative has a structure as shown in a formula I. The heterocycle substituted pyrazine derivative disclosed by the invention has an excellent protection effect on cerebral cortex neuronal cells, and has a remarkable inhibition effect on alpha-syn aggregation and an excellent anti-oxidation effect. Therefore, the heterocyclic substituted pyrazine derivative disclosed by the invention can be used as a medicine for preventing and treating nerve injury, degenerative diseases and ischemic diseases.

According to the cerebral cortex multi-signal layer surface reconstruction method and system and the terminal provided by the invention, signal extraction is performed on the low-signal layer region presented in the image according to the brain region ultrahigh-field magnetic resonance image of the target object, and the initial low-signal layer inner surface and the initial low-signal layer outer surface obtained through extraction are subjected to surface reconstruction on the surface of the target object. Performing iterative optimization based on a preset multi-surface optimization energy function to obtain a target low-signal layer inner surface and a target low-signal layer outer surface; therefore, the multi-signal-layer surface of the cerebral cortex of the target object is reconstructed, and a basis is provided for quantitatively analyzing each signal layer and predicting the development degree and development trend of the cerebral cortex of the target object, whether a lesion occurs or not, the lesion type and the lesion degree and the like.

A method for treating a neurological disorder in an animal. A chitosan Fragmented Physical Hydrogel Suspension (Cfphs) is administered to the animal at a site of spinal cord injury (SCI). Thereafter both (1) cerebral cortex neuromodulation and (2) spinal cord direct current stimulation (tsDCS) are performed on the animal.