The invention discloses
lactobacillus rhamnosus CCFM1228 with functions of relieving depressive
mood and promoting intestinal tract to secrete IgA and application of the
lactobacillus rhamnosus CCFM1228, and belongs to the technical field of microorganisms. The
lactobacillus rhamnosus can relieve depression-like behaviors of depressive mice, increase the content of
neurotransmitter 5-hydroxytryptamine in the brain and increase the BDNF level in
hippocampus of the depressive mice, and the
lactobacillus rhamnosus CCFM1228 has the functions of relieving depressive
mood and promoting intestinal tract to secrete IgA. The expression of
hypothalamus Crh mRNA is inhibited, the level of
corticosterone in serum is reduced, the activity of
xanthine oxidase in
cerebral cortex is reduced, the activity of
adenosine deaminase in liver is improved, and the content of
uric acid in serum is reduced; the
prefrontal lobe Mbp
mRNA level is improved, and the stability of the CNS
myelin sheath
structure and function is maintained; the
mRNA level of the
prefrontal lobe Gfap is improved, and the function of astrocytes is enhanced; the
mRNA level of
hippocampus CD36 is reduced, and immune
homeostasis is regulated; the level of IgA in host
feces can be improved on the basis of relieving the depression
mood, and wide application prospects are achieved.