38 results about "Cortex cerebri" patented technology

The invention relates to the technical field of medical monitoring and early warning, and discloses a postoperative care risk early warning system for neurosurgical patients. According to the system, real-time monitoring flows of electroencephalogram, intracranial pressure and body surface myoelectricity of a patient are continuously received, and a dynamic interaction network of neuroelectrophysiology and intracranial mechanical states is constructed so as to represent the coupling relation among electroencephalogram rhythm, pressure conduction and postoperative skull windowing area tissue compliance. The system analyzes three types of core parameters of cerebral cortex excitability, cerebrospinal fluid circulation load and cranial cavity compensation space from the network, further calculates a brain tissue perfusion risk and a neural structure compression risk, and generates a corresponding nursing early warning signal and a physiological regulation path. According to the scheme, deep coupling and mechanism risk early warning of multiple physiological signals are achieved, and the postoperative complication risk can be recognized earlier and more accurately.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The invention relates to a brain wave signal acquisition device, belongs to the technical field of medical instruments, and solves the problems that in the prior art, a brain wave signal acquisition device is implanted into the cerebral cortex of a human body through craniotomy, the trauma of a patient is large, the surgical risk is high, and various complications can be caused. The brain wave signal acquisition device comprises a bracket main body, an electrode plate and a conductive wire; the stent body is of an open curled cylindrical structure composed of a plurality of grid units, openings are formed in the two axial ends of the stent body, and gaps are formed in the curled butt joint positions on the side wall face of the stent body. The electrode plates are arranged on the grid units; the conductive wire is wound on the stent main body, one end of the conductive wire is connected with the electrode plate, and the other end of the conductive wire is wound to the near end of the stent main body. The brain wave signal acquisition can be realized without a craniotomy operation, so that the trauma to a patient is small, and the operation risk is obviously reduced.

The application provides a wearable portable hairband for mental fatigue detection and intervention, a flexible conductive polymer dry electrode is embedded in the inner side of the hairband, the dry electrode is attached to the scalp through mechanical pressure, and thus inductive collection is realized without conductive paste; the output end of the dry electrode collection signal is directly connected to a collection front end located at the side edge of the hairband through FPC, the front end is integrated with an amplifier and an analog-to-digital converter, weak electrical signals on the cerebral cortex are amplified and converted into a data format; a SoC chip is selected as a processor to build a full-integrated edge computing platform inside the flexible fabric hairband, and the calculation task of mental fatigue detection is sunk to the hairband end; an ultrathin bone conduction unit is used as an acoustic output component, which is connected through a flexible circuit and embedded in the inner side of the hairband corresponding to the anatomical site of the user's temple, when the mental fatigue detection result triggers the fatigue warning threshold, a binaural rhythm intervention module is activated to perform binaural rhythm intervention. The application can perform mental fatigue detection and intervention.

The invention discloses a pain monitoring and rehabilitation equipment control method, device and equipment and a readable storage medium, and relates to the technical field of brain-computer interaction. Comprising the following steps: acquiring a cerebral cortex blood oxygen signal of a target user, and preprocessing the cerebral cortex blood oxygen signal to obtain a preprocessed blood oxygen signal; extracting multi-dimensional features from the preprocessed blood oxygen signals based on a sliding time window; selecting features of which the contribution degree scores are greater than a preset score threshold value from the multi-dimensional features as a target feature set; inputting the target feature set into a pre-trained pain recognition model, and outputting a pain recognition result of the target user; inputting the target feature set into a pre-trained gait recognition model, and outputting a gait recognition result of the target user; and controlling rehabilitation equipment based on the pain recognition result and the gait recognition result. According to the method, secondary injury of the rehabilitation equipment to the user is avoided.

A virtual implant placement interaction method and device are disclosed. The interaction method includes: acquiring a three-dimensional model of the cerebral cortex; updating the position of the implant in response to a received operation command and acquiring the real-time three-dimensional coordinates of the implant; placing the implant in the three-dimensional model of the cerebral cortex, or placing it on the surface of the three-dimensional model of the cerebral cortex; re-rendering the three-dimensional model of the cerebral cortex based on the real-time three-dimensional coordinates of the implant; and outputting the re-rendered three-dimensional model of the cerebral cortex. This solution enables adjustment of the implant's position on the three-dimensional model of the cerebral cortex, providing a direct and real-time display of the operation effect. Furthermore, it eliminates the need to switch between different software during data processing, simplifying the data processing workflow and improving data processing efficiency.

The invention relates to a target spot optimization method and device and a storage medium, and the method comprises the steps: firstly obtaining the head modeling data, brain function partition, intervention process information and intervention curative effect information of a modeling object, then carrying out the calculation of a cerebral cortex induced electric field in an intervention process based on the head modeling data corresponding to the modeling object, and carrying out the calculation of a cerebral cortex induced electric field. Obtaining accumulated cerebral cortex induced electric field distribution in the intervention process, obtaining an induced electric field function connection matrix according to the accumulated cerebral cortex induced electric field distribution and the brain function partition, and finally establishing a target optimization model by utilizing the data of the induced electric field function connection matrix in combination with the intervention curative effect information. By more accurately determining the stimulation pose and parameters, accurate feedback of individual differences of application objects is realized, so that the overall curative effect of intervention is improved.

The present application relates to the technical field of pattern recognition, in particular to a stroke rehabilitation evaluation method based on brain muscle function network features, comprising the following steps: S1, collecting electroencephalogram signals and electromyogram signals, collecting electroencephalogram signals and electromyogram signals of a stroke patient under a hand dynamometer test; S2, respectively pre-processing the electroencephalogram signals and electromyogram signals; S3, constructing a variational mode decomposition transfer entropy; S4, constructing a CMFN model based on EEG and EMG; S5, brain muscle function network analysis. The method considers that the research on motor recovery of stroke stays in analyzing the consistency or coupling relationship changes between the cerebral cortex and the muscle, realizes the quantification of stroke evaluation, and greatly improves the evaluation accuracy.

A method and a system for fully automatically segmenting a cerebral cortex surface based on a graph network, the method including: registering a cerebral magnetic resonance image to a standard template space; performing cerebral cortex surface reconstruction on the registered cerebral magnetic resonance image based on a deep neural network; calculating adjacency matrices among the vertexes of the reconstructed cerebral cortex; acquiring corresponding distinguishing features of each grid vertex of the cerebral cortex surface as corresponding feature vectors of the point so as to obtain a cerebral cortex surface segmentation result; and mapping the cerebral cortex surface segmentation result back to the original coordinate space from the standard template space. Graph structure modeling is performed on the reconstructed cerebral cortex surface, and the global topological structure features are learned based on the graph network, thus realizing the accurate segmentation of the cerebral cortex surface.

Abnormal activity in the brain can be detected by identifying changes in tissue excitability measured in response to stimulation of fiber tracts such as the corpus callosum. A stimulating electrode contact can apply a stimulation to the fiber tract, which can have one or more terminals to a cortex of a patient's brain, and a recording electrode contact positioned in the fiber tract and / or the cortex to record a tissue excitability response to the stimulation. A controller can receive the tissue excitability response from the at least one recording electrode, identify a parameter of the tissue excitability response, and predict the abnormal activity in the patient's brain based on the parameter being different from a baseline for the parameter. When an abnormal activity is predicted the patient can be alerted to start a therapy and / or a therapy can be applied in closed loop manner by a connected therapy device.

The application provides a full hydrogel nerve electrode which is composed of four layers of hydrogel, namely a PSFD hydrogel layer, an LPPDMEA layer, a PSFD hydrogel layer and an MHD layer; the application also provides a preparation method and application of the full hydrogel nerve electrode. The application provides a PEDOT:PSS hydrogel conductive path with ultrahigh conductivity, which achieves a record capacity compared with a metal electrode; the introduction of dopamine in each layer of the full hydrogel nerve electrode ensures excellent interface compliance, so that the full hydrogel nerve electrode can be attached to the complex geometry of soft neural tissue and avoid interface mismatch between the conductive layer, the packaging layer, the shielding layer and the tissue-electrode interface; the natural polymer packaging layer improves compatibility, and the electromagnetic shielding layer is used to improve the signal-to-noise ratio. The full hydrogel nerve electrode can provide artificial electrical stimulation to the cerebral cortex of a rat during a seizure, and the prepared full hydrogel nerve electrode has the potential to become a valuable tool for better understanding the development, function and treatment of brain diseases and neurodegenerative diseases and neurodegenerative diseases.

The invention discloses application of an Islr gene in preparation of drugs for spinal cord injury repair. A transcriptome sequencing result of early spinal cord injury shows that the expression of the Islr gene after spinal cord injury is gradually increased; meanwhile, the expression of Islr is gradually increased in cerebral cortical neurons (the regeneration capacity is gradually weakened) in 1 day (P1) and 3 days (P3) after the rat is cultured in vitro for E18 days, so that the Islr gene is deduced to have an effect on diagnosis and treatment of spinal cord injury. E14-day spinal cord neurons subjected to primary culture are transfected through siRNA, and it is further verified that growth of neuronal axons can be promoted by inhibiting expression of Islr, and the effect on repairing spinal cord injuries is achieved.

The invention provides a nerve stimulation current generating circuit and a nerve stimulator, and relates to the technical field of medical equipment and nerve electrophysiology, the nerve stimulation current generating circuit only generates two-gear stimulation current, the stimulation current is small, the stimulation mode is simple, and the nerve stimulation current generating circuit is more specially used for cerebral cortex stimulation. The two-gear bipolar constant-current stimulation unit converts the polarity of two-gear stimulation current to generate bipolar nerve stimulation current, and during cerebral cortex stimulation, polarity conversion can alleviate the pulse intensity of two adjacent stimulation currents, reduce side effects on a human body and reduce corrosion to electrodes of a circuit. The nerve stimulator provided by the invention does not need high-value devices such as a single chip microcomputer and a digital analog converter, can be realized by a pure analog technology, reduces the complexity of equipment, is low in application cost and disposable, and reduces the risk of surgical infection.

This invention discloses a method for segmenting cerebral blood vessels in non-angiographic images, comprising the following steps: S1, inputting the original image A, i.e., the original non-angiographic image; S2, filtering out air, outputting image B; S3, dissecting the skull, outputting image C; S4, performing preliminary ablation of the cerebral cortex, outputting image D; S5, iteratively ablating the cerebral cortex, outputting image E, i.e., the final cerebral blood vessel image. This invention can dissect the skull and iteratively ablate the cerebral cortex without affecting the vascular components, thereby obtaining the purest and most complete cerebral blood vessel components possible.

The invention relates to a transcranial ultrasonic nerve regulation and control device and a control method. The transcranial ultrasonic nerve regulation and control device comprises an ultrasonic generation unit, ultrasonic waves are controllably provided to an intracranial target area, and the ultrasonic generation unit is configured to provide the ultrasonic waves with the frequency ranging from 3.0 MHz to 8.0 MHz to the intracranial target area. According to the transcranial ultrasonic nerve regulation device and the control method, the intracranial nerves are stimulated through the high-frequency ultrasonic waves with the working frequency of 3.0-8.0 MHz, the transcranial ultrasonic nerve regulation device and the control method have remarkable advantages in cortex regulation, energy is more easily absorbed by superficial tissue, the stimulated area covers the cerebral cortex and superficial white matter, and interference of a non-targeted deep structure is avoided. Meanwhile, the spatial resolution of the ultrasound of the frequency band can reach the submillimeter level, the ultrasound can be accurately focused on a tiny functional subregion, and the ultrasound is particularly suitable for nerve regulation scenes needing accurate positioning intervention and is suitable for nerve regulation of focal epilepsy, chronic pain syndromes, visual and auditory cortex dysfunction and mental and psychological disorders.

The invention discloses an implant virtual placement interaction method and device. The interaction method comprises the following steps: acquiring a three-dimensional model of a cerebral cortex; in response to a received operation instruction, updating the position of the implant, and obtaining a real-time three-dimensional coordinate of the implant; the implant is placed in the three-dimensional model of the cerebral cortex or placed on the surface of the three-dimensional model of the cerebral cortex; re-rendering the three-dimensional model of the cerebral cortex based on the real-time three-dimensional coordinates of the implant; and outputting the re-rendered three-dimensional model of the cerebral cortex. According to the scheme, the position of the implant can be adjusted on the three-dimensional model of the cerebral cortex, and the operation effect is visually displayed in real time. Moreover, in the data processing process, switching between different software is not needed, the data processing flow is simplified, and the data processing efficiency is improved.

The application discloses a head-mounted high-precision optogenetic stimulation device for non-human primate cerebral cortex, comprising a MicroLED display device configured to provide image light and project a stimulation pattern; and an imaging lens configured to image the stimulation pattern output by the MicroLED display device to the cerebral cortex of the non-human primate, the imaging lens being a full-symmetrical structure, and sequentially comprising a second lens group, a third lens group, a diaphragm, a fourth lens group and a fifth lens group along an optical transmission direction, wherein the third lens group and the fourth lens group are symmetrical about the diaphragm, the second lens group and the fifth lens group are symmetrical about the diaphragm, and the imaging magnification of the imaging lens is between 1.0 and 1.1 times. The optogenetic stimulation device can project different patterns at different positions in the target area of the cerebral cortex according to requirements, is light in weight, and can be set to different brightness and colors.

The invention belongs to the technical field of medicines, and particularly relates to a mitochondria-rich extracellular vesicle derived from periodontal cells and application of the extracellular vesicle in ischemic brain injury. The extraction method of the extracellular vesicles comprises the following steps: (1) chopping a cerebral cortex part, adding type II collagenase and DNaseI for digestion, and then adding a gradient separation medium for separation to obtain pericytes; (2) spreading the periodontal cells on a culture dish coated with IV-type collagen, and culturing in a periodontal cell culture medium; and (3) when the confluence degree of the cells reaches 80%-90%, replacing the cell culture medium with a fresh culture medium without exosome FBS, reoxygenating the cells for 24 hours after OGD treatment, collecting culture supernatant, and centrifuging the culture supernatant to obtain the extracellular vesicles. It is found for the first time that the PC-EVs obtained after OGD stress can protect the brain from ischemic stroke injury, and the PC-EVs have important reference significance for researching related drugs for treating ischemic brain injury.

Methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain are provided. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.

The invention belongs to the technical field of nondestructive testing, and discloses a temperature-controllable mouse brain monitoring device and a working method.The temperature-controllable mouse brain monitoring device is characterized in that a light-transmitting device is matched with a two-photon microscope, and cerebral cortex nerve and blood vessel change images can be clearly collected; a horn-shaped through hole design of the temperature regulating and controlling head part is combined with a liquid circulating system driven by an injection pump and a peristaltic pump, the brain temperature can be precisely regulated and controlled, and a threaded connection mode of a medical silicone tube ensures that liquid transmission is sealed and stable. Meanwhile, the temperature measuring guide wire collects the temperature in the cranial cavity in real time, data and imaging information are uploaded to a computer, automatic synchronization of temperature regulation and control, image collection and data analysis is achieved, and manual operation errors are reduced. In experiments for observing the influence of low temperature on cerebral blood flow and the like, accurate imaging can be realized by injecting the fluorescent agent through the caudal vein, so that the experimental efficiency is improved, the data accuracy is ensured, and an integrated and high-precision experimental tool is provided for researching a brain physiological mechanism.

The invention discloses a cinnabar nano-vesicle gel emplastrum with a tranquilizing and calming effect as well as a preparation method and application of the cinnabar nano-vesicle gel emplastrum. The method comprises the following steps: preparing target peptide modified cinnabar nano-vesicles by adopting a film dispersion method; dissolving cinnabar nano-vesicles in PBS as a phase C for later use; mixing the second framework material, the tackifier, the filler and the humectant to obtain a phase A; mixing a cross-linking agent, a cross-linking regulator, a penetration enhancer and a bacteriostatic agent to obtain a phase B; stirring and mixing the phase A, the phase B and the phase C, coating a non-woven fabric with the mixture, placing the non-woven fabric at room temperature, and covering the non-woven fabric with an anti-sticking film to obtain the target peptide modified cinnabar nano-vesicle gel emplastrum. The cinnabar nano-vesicle gel emplastrum can promote intestinal microorganisms to generate 5-hydroxytryptamine (5-HT), so that a cerebral cortex 5-HT1AR-cAMP pathway is activated, brain activity is adjusted, sleep conditions are improved, the cinnabar nano-vesicle gel emplastrum has slow release property, skin penetrability and intestinal tract targeting property, and the insecurity caused by direct oral administration of cinnabar into blood circulation is also solved.

A method of rapid constructing human cerebral cortical organoids by 3D bioprinting and an application including preparing microfluidic chips, preparation of hydrogel of human cerebral cortical organoids, and printing of human cerebral cortical organoids. The microfluidic chip comprises a mixed-flow channel layer, liquid pool layer, microporous array layer, human cerebral cortical organoid culture layer, and culture medium recovery layer; the human cerebral cortical organoid hydrogel has gelatin, alginate, and hyaluronic acid; printing directly human cerebral cortical organoids in microfluidic chips by FRESH printing method, obtaining human cerebral cortical organoid chips after packaging. The application directly constructs large-scale human cerebral cortex-like with three layers of mutually connected structures in situ in organ chip through 3D bioprinting, simulates cerebrospinal fluid circulation through perfusion culture.

This application discloses the application of Bcl11a in the preparation of drugs for nerve injury repair, belonging to the field of biomedical technology. The nerve injury is a central nervous system injury. Overexpression of Bcl11a promotes the transdifferentiation of an intermediate state astrocyte in the cerebral cortex into pyramidal neurons. Using Bcl11a as a molecular intervention target, targeting the M1 motor area of ​​the cerebral cortex, overexpression of Bcl11a in astrocyte subset 2 promotes the reprogramming of astrocytes into pyramidal neurons, promoting the repair of central nervous system injury. Using spatial transcriptome sequencing technology and single-cell sequencing technology, the dynamic trajectory between astrocytes and pyramidal cells was depicted, supporting the transformation of an intermediate transitional state astrocyte in the cortex into pyramidal cell subset 3 after spinal cord injury, indicating that Bcl11a and Zmart4 are key transcription factors in the connection between pyramidal cells and glial cells.

The invention relates to an intelligent mind and pupil monitoring method and device, and the method comprises the steps: collecting a brain heat radiation signal, a micro-motion feature and a pupil video sequence of a patient, and obtaining the cerebral cortex neural activity data of the patient; inputting the pupil video sequence into a deformed pupil positioning model, and extracting a pupil contour, a pupil diameter, a light reflex incubation period and a contraction speed curve; inputting the brain heat radiation signal, the micro-motion characteristic and the cerebral cortex neural activity data into a time-frequency fusion neural network model, and identifying the consciousness state of the patient; according to the pupil contour, the pupil diameter, the light reflex incubation period, the contraction speed curve and the consciousness state of the patient, a comprehensive neural state index report of the patient is generated. According to the method, sub-pixel-level pupil contour segmentation is achieved, the pupil diameter is accurately extracted, the method has higher adaptability to light reflection latency and contraction speed curves, pupil deformation, shielding and illumination changes, and finer changes of the consciousness state can be captured.

The invention relates to an application of CGS21680 in preparation of an intervention drug for preventing / treating autism, the CGS21680 can activate A2AR, down-regulate the levels of TNF-alpha, IL-6 and MCP-1 in cerebral cortex tissues and reduce the inflammation of a central nervous system in the early stage after growth so as to intervene in autism spectrum disorder engraving behaviors, and the drug effect of the early intervention after growth can last to the adult stage. The autism related behaviors after the adult are improved. An animal level experiment result shows that A2AR is activated in the early stage of the mouse after birth, so that the activation degree of microglial cells of the cortex of the BTBR mouse can be remarkably reduced, the neural immune microenvironment of the cortex of the mouse is improved, the defects of a three-box social experiment of the adult BTBR mouse are improved, the engraving behavior, the spontaneous activity capability and the anxiety behavior of the adult BTBR mouse are reduced, and the survival rate of the adult BTBR mouse is increased. And the adult BTBR mouse is protected from being influenced by autism-related behaviors.

The invention provides an in-vitro cerebral cortex intermediate neuron precursor cell population as well as a preparation method and application of the in-vitro cerebral cortex intermediate neuron precursor cell population. According to the cell population, the iNSC is taken as an initial cell to directionally differentiate to the neuroectoderm cell, so that neuroendoderm and neuromesoderm impurity cells generated in the differentiation process can be reduced, the cell differentiation direction is more accurate, and the differentiated cell purity is higher. The cell population can be used for the prevention, diagnosis and treatment of nervous system diseases.

The invention discloses a head-mounted non-human primate cerebral cortex high-precision optical genetic stimulation device, which comprises a MicroLED display device, an optical genetic stimulation device, an optical genetic stimulation device and an optical genetic stimulation device, and is characterized in that the MicroLED display device is configured to provide image light and project a stimulation pattern; the imaging lens is configured to image stimulation patterns output by the MicroLED display device to the cerebral cortex of the non-human primate animal, the imaging lens is of a holosymmetric structure, and the imaging lens sequentially comprises a second lens group, a third lens group, a diaphragm, a fourth lens group and a fifth lens group in the light transmission direction; wherein the third lens group and the fourth lens group are symmetrical about the diaphragm, the second lens group and the fifth lens group are symmetrical about the diaphragm, the imaging magnification of the imaging lens is 1.0-1.1 times, the optical genetic stimulation equipment can project different patterns at different positions in a cerebral cortex target area according to requirements, the weight is light, and different brightness and colors can be set.

The invention discloses an individualized wearable transcranial magnetic stimulation treatment assisted positioning method, which comprises the following steps: based on T1 weighted structure imaging, obtaining a scalp surface, a skull surface and a cerebral cortex surface consistent with an individual head anatomy through surface reconstruction; on the basis of resting state functional magnetic resonance imaging, whole brain function connection analysis is executed to obtain an individualized cortex target spot; identifying anatomical mark points on the scalp surface and constructing a scalp curved surface coordinate system, and projecting the individualized cortex target spot from the cerebral cortex surface to the scalp surface to obtain an individualized scalp target spot position; selecting a scalp curved surface above an ear plane in the scalp curved surface coordinate system as a hood base area, making a three-dimensional model of the individualized positioning hood, and reserving a coil placement area corresponding to the individualized scalp target according to the position of the individualized scalp target; an individualized positioning hood entity is manufactured according to the three-dimensional model, and individualized accurate positioning, repeated placement and standardized operation of transcranial magnetic stimulation are achieved.

The invention discloses a method for researching an influence mechanism of TBMT on upper limb recovery of a stroke patient, and relates to the technical field of neurological rehabilitation and biomedical engineering. The system is realized based on a multi-modal evaluation system, and the system comprises a task-oriented mirror image therapeutic instrument which is used for guiding a patient to carry out specific hand task training; the near infrared spectrum detection module is used for collecting blood oxygen signals of the cerebral cortex of the patient in a resting state and a task state so as to evaluate the brain function connection strength and the brain region activation level; and the surface electromyographic signal acquisition module is used for acquiring electromyographic signals of related muscles when the patient executes the grasping action. The TBMT is deeply combined with the resting state / task state of the fNIRS and the sEMG, and the biological basis of the curative effect of the TBMT is clearly and objectively revealed from two dimensions of central nervous remodeling and peripheral function output; quantitative physiological signals are used for replacing or supplementing a subjective scale, so that curative effect evaluation is more accurate and sensitive, and early-stage and subtle rehabilitation progress can be found.

The present disclosure relates to a food composition comprising hemp seed cake as an active ingredient for enhancing GABA in serum and the cerebral cortex, wherein GABA is enhanced through edestin, an active component contained in the hemp seed cake. According to the present invention, the hemp seed cake extracted independently can provide a large amount of protein and dietary fiber without tolerance, and particularly, through edestin contained in the hemp seed cake, can enhance GABA in serum and the cerebral cortex and induce sleep.