70 results about "Cortex cerebri" patented technology

The invention relates to the technical field of medical monitoring and early warning, and discloses a postoperative care risk early warning system for neurosurgical patients. According to the system, real-time monitoring flows of electroencephalogram, intracranial pressure and body surface myoelectricity of a patient are continuously received, and a dynamic interaction network of neuroelectrophysiology and intracranial mechanical states is constructed so as to represent the coupling relation among electroencephalogram rhythm, pressure conduction and postoperative skull windowing area tissue compliance. The system analyzes three types of core parameters of cerebral cortex excitability, cerebrospinal fluid circulation load and cranial cavity compensation space from the network, further calculates a brain tissue perfusion risk and a neural structure compression risk, and generates a corresponding nursing early warning signal and a physiological regulation path. According to the scheme, deep coupling and mechanism risk early warning of multiple physiological signals are achieved, and the postoperative complication risk can be recognized earlier and more accurately.

The invention discloses a peripheral-central-peripheral evaluation system based on electroencephalogram-myoelectricity dual-channel bidirectional mixed feedback, and the system is characterized in that a muscle electrical stimulation module is used for providing a current with a specific frequency, and carrying out the electrical stimulation of muscles; the transcranial direct current stimulation module is used for providing current with specific frequency and performing electrical stimulation on the cerebral cortex; the myoelectricity acquisition module and the electroencephalogram acquisition module respectively acquire electric signal data of tested muscles and cerebral cortex and transmit the electric signal data to the upper computer feedback module, and the upper computer feedback module is used for controlling the muscle electrical stimulation module and the transcranial direct current stimulation module to generate electrical stimulation and acquiring data acquired by the myoelectricity acquisition module and the electroencephalogram acquisition module; and the data is evaluated after being processed, and an evaluation result is sent to the terminal display module for real-time display. According to the scheme, in the evaluation process, through a bidirectional mixed feedback mechanism, accurate positioning of cerebral cortex and muscle group stimulation targets is achieved, the electrical stimulation and evaluation effect can be optimized, quantitative evaluation is conducted on the result through a bidirectional evaluation model, scientific quantitative indexes are provided, the influence of individual differences and state changes on the evaluation result is reduced, and the evaluation accuracy is improved. And the reliability and stability of evaluation are improved.

The invention provides a three-dimensional flexible neural microelectrode and an array and a preparation method thereof. The three-dimensional flexible neural microelectrode comprises a cortical electrode part which comprises a first electrode site, and the first electrode site is used for recording a cortical electroencephalogram signal of a to-be-detected body when the cortical electrode part is attached to the cerebral cortical surface of the to-be-detected body; the implanted electrode part comprises a second electrode site, and the second electrode site is used for recording a single neuron discharge signal of the to-be-detected body when the implanted electrode part is implanted into the cerebral cortex of the to-be-detected body; wherein the cortical electrode part is located in an area defined by the implanted electrode part, so that when the implanted electrode part is implanted into the cerebral cortex, the relative position of the cortical electrode part and the surface of the cerebral cortex is kept fixed.

The invention discloses an auxiliary device for armless disabled people, and relates to the technical field of brain-computer interfaces. In order to solve the problems that in the prior art, an invasive type and a semi-invasive type of existing wearable auxiliary devices for providing life assistance for people with upper limb disability need surgical operation, electrodes are implanted into the cerebral cortex, but the surgical risk is large, complications such as infection and bleeding are possibly caused, and long-term maintenance is needed after implantation; in order to solve the technical problems that a non-invasive interbrain interface is relatively small in risk, convenient to use, simple to operate, low in cost and relatively low in control precision, the technical scheme provided by the invention is as follows: the auxiliary system for the armless disabled person comprises a brain signal acquisition module for acquiring an electroencephalogram signal of a user in a non-invasive manner; the visual control module is used for collecting target object positioning information; and the main control module is used for generating grabbing action group signals according to the signals acquired by the brain signal acquisition module and the visual control module. The auxiliary grabbing device is suitable for being applied to auxiliary grabbing work of the arm-free handicapped.

The invention provides a response liposome for treating traumatic brain injury by targeting a blood-brain barrier loaded drug and a preparation method of the response liposome, and belongs to the field of traumatic brain injury treatment.The response liposome is prepared by preparing TfR-T12 target peptide firstly, then preparing nano-particles with hydrophobic molecular drugs wrapped inside, and finally preparing the TfR-T12 target peptide with the hydrophobic molecular drugs wrapped inside. And finally, preparing the response liposome for treating traumatic brain injury by the targeted blood-brain barrier loaded medicine. According to the application, the TfR-T12 target peptide which is highly expressed in cerebral cortex microvessels and can help a nano-drug to pass through a blood brain barrier through endocytosis is prepared as a target spot, meanwhile, the liposome is subjected to polypeptide modification, and the self-assembly driving force of the nano-particles is improved through process control; the outer surface of the response lipidosome is a target peptide, and the response lipidosome is internally coated with a nano-drug; the liposome can repair the blood brain barrier after injury, improve the blood flow of the brain, improve the drainage of the colloidal lymphatic system, improve the motor and cognitive functions of mice after injury, and reduce the dosage of drugs and various possible side effects caused by the drug dosage.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The invention relates to a brain wave signal acquisition device, belongs to the technical field of medical instruments, and solves the problems that in the prior art, a brain wave signal acquisition device is implanted into the cerebral cortex of a human body through craniotomy, the trauma of a patient is large, the surgical risk is high, and various complications can be caused. The brain wave signal acquisition device comprises a bracket main body, an electrode plate and a conductive wire; the stent body is of an open curled cylindrical structure composed of a plurality of grid units, openings are formed in the two axial ends of the stent body, and gaps are formed in the curled butt joint positions on the side wall face of the stent body. The electrode plates are arranged on the grid units; the conductive wire is wound on the stent main body, one end of the conductive wire is connected with the electrode plate, and the other end of the conductive wire is wound to the near end of the stent main body. The brain wave signal acquisition can be realized without a craniotomy operation, so that the trauma to a patient is small, and the operation risk is obviously reduced.

The application provides a wearable portable hairband for mental fatigue detection and intervention, a flexible conductive polymer dry electrode is embedded in the inner side of the hairband, the dry electrode is attached to the scalp through mechanical pressure, and thus inductive collection is realized without conductive paste; the output end of the dry electrode collection signal is directly connected to a collection front end located at the side edge of the hairband through FPC, the front end is integrated with an amplifier and an analog-to-digital converter, weak electrical signals on the cerebral cortex are amplified and converted into a data format; a SoC chip is selected as a processor to build a full-integrated edge computing platform inside the flexible fabric hairband, and the calculation task of mental fatigue detection is sunk to the hairband end; an ultrathin bone conduction unit is used as an acoustic output component, which is connected through a flexible circuit and embedded in the inner side of the hairband corresponding to the anatomical site of the user's temple, when the mental fatigue detection result triggers the fatigue warning threshold, a binaural rhythm intervention module is activated to perform binaural rhythm intervention. The application can perform mental fatigue detection and intervention.

The invention discloses a pain monitoring and rehabilitation equipment control method, device and equipment and a readable storage medium, and relates to the technical field of brain-computer interaction. Comprising the following steps: acquiring a cerebral cortex blood oxygen signal of a target user, and preprocessing the cerebral cortex blood oxygen signal to obtain a preprocessed blood oxygen signal; extracting multi-dimensional features from the preprocessed blood oxygen signals based on a sliding time window; selecting features of which the contribution degree scores are greater than a preset score threshold value from the multi-dimensional features as a target feature set; inputting the target feature set into a pre-trained pain recognition model, and outputting a pain recognition result of the target user; inputting the target feature set into a pre-trained gait recognition model, and outputting a gait recognition result of the target user; and controlling rehabilitation equipment based on the pain recognition result and the gait recognition result. According to the method, secondary injury of the rehabilitation equipment to the user is avoided.

A virtual implant placement interaction method and device are disclosed. The interaction method includes: acquiring a three-dimensional model of the cerebral cortex; updating the position of the implant in response to a received operation command and acquiring the real-time three-dimensional coordinates of the implant; placing the implant in the three-dimensional model of the cerebral cortex, or placing it on the surface of the three-dimensional model of the cerebral cortex; re-rendering the three-dimensional model of the cerebral cortex based on the real-time three-dimensional coordinates of the implant; and outputting the re-rendered three-dimensional model of the cerebral cortex. This solution enables adjustment of the implant's position on the three-dimensional model of the cerebral cortex, providing a direct and real-time display of the operation effect. Furthermore, it eliminates the need to switch between different software during data processing, simplifying the data processing workflow and improving data processing efficiency.

The present invention discloses a univariate neurodegenerative biomarker for early detection of AD, belonging to the technical field of Alzheimer's disease recognition. By assigning different weights to different regions of interest, a reliable and robust univariate morphometric index is generated to reflect the morphological changes of the brain caused by Alzheimer's disease. Compared with traditional univariate biomarkers, the present invention has higher statistical power and can better characterize the morphological changes of the cerebral cortex caused by Alzheimer's disease.

The invention relates to a target spot optimization method and device and a storage medium, and the method comprises the steps: firstly obtaining the head modeling data, brain function partition, intervention process information and intervention curative effect information of a modeling object, then carrying out the calculation of a cerebral cortex induced electric field in an intervention process based on the head modeling data corresponding to the modeling object, and carrying out the calculation of a cerebral cortex induced electric field. Obtaining accumulated cerebral cortex induced electric field distribution in the intervention process, obtaining an induced electric field function connection matrix according to the accumulated cerebral cortex induced electric field distribution and the brain function partition, and finally establishing a target optimization model by utilizing the data of the induced electric field function connection matrix in combination with the intervention curative effect information. By more accurately determining the stimulation pose and parameters, accurate feedback of individual differences of application objects is realized, so that the overall curative effect of intervention is improved.

The invention relates to the field of medical care, and particularly discloses a cerebral cortex state detection method and system based on a disturbance of consciousness detection model, and the method comprises the steps: dividing a cerebral cortex region according to different functional regions of the cerebral cortex, and obtaining different cerebral cortex monitoring sub-regions; the corresponding relation between the cerebral cortex monitoring sub-areas and the data acquisition point density is obtained in a cloud medical data server, and a data acquisition point distribution scheme of each cerebral cortex monitoring sub-area is obtained; the data acquisition point data management module acquires initial monitoring data of each cerebral cortex monitoring sub-region according to the data acquisition point distribution scheme; and comparing the monitoring data sequence of the cerebral cortex monitoring sub-region sequence of the corresponding stimulation type with the initial monitoring data sequence of the corresponding cerebral cortex monitoring sub-region one by one to complete the state detection of the cerebral cortex state. According to the invention, the neural activity state of the cerebral cortex can be monitored and evaluated in real time.

The present application relates to the technical field of pattern recognition, in particular to a stroke rehabilitation evaluation method based on brain muscle function network features, comprising the following steps: S1, collecting electroencephalogram signals and electromyogram signals, collecting electroencephalogram signals and electromyogram signals of a stroke patient under a hand dynamometer test; S2, respectively pre-processing the electroencephalogram signals and electromyogram signals; S3, constructing a variational mode decomposition transfer entropy; S4, constructing a CMFN model based on EEG and EMG; S5, brain muscle function network analysis. The method considers that the research on motor recovery of stroke stays in analyzing the consistency or coupling relationship changes between the cerebral cortex and the muscle, realizes the quantification of stroke evaluation, and greatly improves the evaluation accuracy.

A method and a system for fully automatically segmenting a cerebral cortex surface based on a graph network, the method including: registering a cerebral magnetic resonance image to a standard template space; performing cerebral cortex surface reconstruction on the registered cerebral magnetic resonance image based on a deep neural network; calculating adjacency matrices among the vertexes of the reconstructed cerebral cortex; acquiring corresponding distinguishing features of each grid vertex of the cerebral cortex surface as corresponding feature vectors of the point so as to obtain a cerebral cortex surface segmentation result; and mapping the cerebral cortex surface segmentation result back to the original coordinate space from the standard template space. Graph structure modeling is performed on the reconstructed cerebral cortex surface, and the global topological structure features are learned based on the graph network, thus realizing the accurate segmentation of the cerebral cortex surface.

Abnormal activity in the brain can be detected by identifying changes in tissue excitability measured in response to stimulation of fiber tracts such as the corpus callosum. A stimulating electrode contact can apply a stimulation to the fiber tract, which can have one or more terminals to a cortex of a patient's brain, and a recording electrode contact positioned in the fiber tract and / or the cortex to record a tissue excitability response to the stimulation. A controller can receive the tissue excitability response from the at least one recording electrode, identify a parameter of the tissue excitability response, and predict the abnormal activity in the patient's brain based on the parameter being different from a baseline for the parameter. When an abnormal activity is predicted the patient can be alerted to start a therapy and / or a therapy can be applied in closed loop manner by a connected therapy device.

The application provides a full hydrogel nerve electrode which is composed of four layers of hydrogel, namely a PSFD hydrogel layer, an LPPDMEA layer, a PSFD hydrogel layer and an MHD layer; the application also provides a preparation method and application of the full hydrogel nerve electrode. The application provides a PEDOT:PSS hydrogel conductive path with ultrahigh conductivity, which achieves a record capacity compared with a metal electrode; the introduction of dopamine in each layer of the full hydrogel nerve electrode ensures excellent interface compliance, so that the full hydrogel nerve electrode can be attached to the complex geometry of soft neural tissue and avoid interface mismatch between the conductive layer, the packaging layer, the shielding layer and the tissue-electrode interface; the natural polymer packaging layer improves compatibility, and the electromagnetic shielding layer is used to improve the signal-to-noise ratio. The full hydrogel nerve electrode can provide artificial electrical stimulation to the cerebral cortex of a rat during a seizure, and the prepared full hydrogel nerve electrode has the potential to become a valuable tool for better understanding the development, function and treatment of brain diseases and neurodegenerative diseases and neurodegenerative diseases.

The invention discloses application of an Islr gene in preparation of drugs for spinal cord injury repair. A transcriptome sequencing result of early spinal cord injury shows that the expression of the Islr gene after spinal cord injury is gradually increased; meanwhile, the expression of Islr is gradually increased in cerebral cortical neurons (the regeneration capacity is gradually weakened) in 1 day (P1) and 3 days (P3) after the rat is cultured in vitro for E18 days, so that the Islr gene is deduced to have an effect on diagnosis and treatment of spinal cord injury. E14-day spinal cord neurons subjected to primary culture are transfected through siRNA, and it is further verified that growth of neuronal axons can be promoted by inhibiting expression of Islr, and the effect on repairing spinal cord injuries is achieved.

A neuroprosthetic system for substituting a sensory modality of a mammal by electrical stimulation of a region of the cerebral cortex corresponding to the neural modality to be substituted. The system includes at least one sensor for generating a sensed data feed by sensing a neural modality to be substituted, an electrode unit including a plurality of three-dimensional arrays of flexible electrode shafts for implantation of a region of the cerebral cortex, a rigid electrode support structure for guiding the flexible electrode shafts into the region of the cerebral cortex and for retraction after implantation, a driving unit for electrically driving the electrode, a recording unit, and a processing unit for analysing sensed data feed for providing stimulation patterns for electrically driving groups of electrical contacts of the electrode unit corresponding to subsets of locations in the region of the cerebral cortex, for substituting the sensory modality.

The invention relates to a new application of N, N-diethyl-2-hydroxyphenylacetamide. It is unexpectedly found that N, N-diethyl-2-hydroxyphenylacetamide or a derivative thereof of the present application has a sedative effect, so that N, N-diethyl-2-hydroxyphenylacetamide or a derivative thereof can be used for sedation or prevention and / or treatment of diseases or conditions associated with a non-sedative state. According to the present invention, the N, N-diethyl-2-hydroxyphenylacetamide or the derivative thereof can be adopted as the active component of the sedative drug, and can provide significant sedative and hypnotic effects on mice, and the research results show that DEM has significant inhibition effects on the L-Glu content in the cerebral cortex and other parts of the brain, such that more choices can be provided for the development of the sedative drug.

A system and method is provided for imaging and monitoring a tissue, such as a cerebral cortex, of a subject. Access to imaging a tissue, such as cerebral cortex, may be provided by removing a portion of a bone, such as a portion of a skull of the subject. A prosthesis, such as an optically transparent prosthesis, may be used to replace the portion of the skull removed and may be conformed to the same 3D contour of the bone that was removed. A data acquisition system, such as an imaging system, may then be affixed to the skull prosthesis and may be used to acquire image data of the tissue of the subject at high spatial and temporal resolution and without interference from intervening bone material.

The invention provides a nerve stimulation current generating circuit and a nerve stimulator, and relates to the technical field of medical equipment and nerve electrophysiology, the nerve stimulation current generating circuit only generates two-gear stimulation current, the stimulation current is small, the stimulation mode is simple, and the nerve stimulation current generating circuit is more specially used for cerebral cortex stimulation. The two-gear bipolar constant-current stimulation unit converts the polarity of two-gear stimulation current to generate bipolar nerve stimulation current, and during cerebral cortex stimulation, polarity conversion can alleviate the pulse intensity of two adjacent stimulation currents, reduce side effects on a human body and reduce corrosion to electrodes of a circuit. The nerve stimulator provided by the invention does not need high-value devices such as a single chip microcomputer and a digital analog converter, can be realized by a pure analog technology, reduces the complexity of equipment, is low in application cost and disposable, and reduces the risk of surgical infection.

This invention discloses a method for segmenting cerebral blood vessels in non-angiographic images, comprising the following steps: S1, inputting the original image A, i.e., the original non-angiographic image; S2, filtering out air, outputting image B; S3, dissecting the skull, outputting image C; S4, performing preliminary ablation of the cerebral cortex, outputting image D; S5, iteratively ablating the cerebral cortex, outputting image E, i.e., the final cerebral blood vessel image. This invention can dissect the skull and iteratively ablate the cerebral cortex without affecting the vascular components, thereby obtaining the purest and most complete cerebral blood vessel components possible.

The invention relates to a transcranial ultrasonic nerve regulation and control device and a control method. The transcranial ultrasonic nerve regulation and control device comprises an ultrasonic generation unit, ultrasonic waves are controllably provided to an intracranial target area, and the ultrasonic generation unit is configured to provide the ultrasonic waves with the frequency ranging from 3.0 MHz to 8.0 MHz to the intracranial target area. According to the transcranial ultrasonic nerve regulation device and the control method, the intracranial nerves are stimulated through the high-frequency ultrasonic waves with the working frequency of 3.0-8.0 MHz, the transcranial ultrasonic nerve regulation device and the control method have remarkable advantages in cortex regulation, energy is more easily absorbed by superficial tissue, the stimulated area covers the cerebral cortex and superficial white matter, and interference of a non-targeted deep structure is avoided. Meanwhile, the spatial resolution of the ultrasound of the frequency band can reach the submillimeter level, the ultrasound can be accurately focused on a tiny functional subregion, and the ultrasound is particularly suitable for nerve regulation scenes needing accurate positioning intervention and is suitable for nerve regulation of focal epilepsy, chronic pain syndromes, visual and auditory cortex dysfunction and mental and psychological disorders.

The invention discloses application of negative oxygen ions in intelligent wearing shoes, clothing and textiles, and belongs to the technical field of negative oxygen ion fabric application. Negative oxygen ions are applied to the field of intelligent wearing shoes and textiles, the negative oxygen ions can be released in a natural mode in shoe products, foot diseases are prevented and treated, local air is purified, microcirculation is improved, and fatigue is relieved; the air quality is improved, the health-care effects of enhancing the cerebral cortex function, promoting blood circulation, improving immunity and the like are achieved, the accessory products can form a negative oxygen ion environment, and the body function is effectively adjusted. The textile product has the function of releasing negative oxygen ions for a long time, the natural properties of intelligence, health care and health preservation of shoe and clothing products are expanded, the negative oxygen ion textile product and the intelligent wearable shoe and clothing products are perfectly combined, the human immunity can be enhanced, diseases are reduced, the average life of human beings is artificially prolonged, the economic structure is improved, and the development of social productivity is powerfully promoted.

The invention discloses an implant virtual placement interaction method and device. The interaction method comprises the following steps: acquiring a three-dimensional model of a cerebral cortex; in response to a received operation instruction, updating the position of the implant, and obtaining a real-time three-dimensional coordinate of the implant; the implant is placed in the three-dimensional model of the cerebral cortex or placed on the surface of the three-dimensional model of the cerebral cortex; re-rendering the three-dimensional model of the cerebral cortex based on the real-time three-dimensional coordinates of the implant; and outputting the re-rendered three-dimensional model of the cerebral cortex. According to the scheme, the position of the implant can be adjusted on the three-dimensional model of the cerebral cortex, and the operation effect is visually displayed in real time. Moreover, in the data processing process, switching between different software is not needed, the data processing flow is simplified, and the data processing efficiency is improved.

The application discloses a head-mounted high-precision optogenetic stimulation device for non-human primate cerebral cortex, comprising a MicroLED display device configured to provide image light and project a stimulation pattern; and an imaging lens configured to image the stimulation pattern output by the MicroLED display device to the cerebral cortex of the non-human primate, the imaging lens being a full-symmetrical structure, and sequentially comprising a second lens group, a third lens group, a diaphragm, a fourth lens group and a fifth lens group along an optical transmission direction, wherein the third lens group and the fourth lens group are symmetrical about the diaphragm, the second lens group and the fifth lens group are symmetrical about the diaphragm, and the imaging magnification of the imaging lens is between 1.0 and 1.1 times. The optogenetic stimulation device can project different patterns at different positions in the target area of the cerebral cortex according to requirements, is light in weight, and can be set to different brightness and colors.

The invention belongs to the technical field of medicines, and particularly relates to a mitochondria-rich extracellular vesicle derived from periodontal cells and application of the extracellular vesicle in ischemic brain injury. The extraction method of the extracellular vesicles comprises the following steps: (1) chopping a cerebral cortex part, adding type II collagenase and DNaseI for digestion, and then adding a gradient separation medium for separation to obtain pericytes; (2) spreading the periodontal cells on a culture dish coated with IV-type collagen, and culturing in a periodontal cell culture medium; and (3) when the confluence degree of the cells reaches 80%-90%, replacing the cell culture medium with a fresh culture medium without exosome FBS, reoxygenating the cells for 24 hours after OGD treatment, collecting culture supernatant, and centrifuging the culture supernatant to obtain the extracellular vesicles. It is found for the first time that the PC-EVs obtained after OGD stress can protect the brain from ischemic stroke injury, and the PC-EVs have important reference significance for researching related drugs for treating ischemic brain injury.

Methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain are provided. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.

It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the intracerebroventricular (ICV) or intrathecal (cisternal or lumbar) route exhibit different cellular tropisms in the central nervous system. Thus, a subject can be treated by injection into the CSF of ssAAV or scAAV vector encoding a therapeutic protein, such as an ssAAV9 or scAAV9 vector. The therapeutic protein can be targeted to specific cells using these vectors. In some embodiments, scAAV9 is utilized to achieve superior transduction in the hippocampus, cerebellum and cerebral cortex where both neurons, particularly Purkinje neurons, and glial cells (such as astrocytes) are transduced. In other embodiments, ssAAV9 is utilized to minimize transduction of astrocytes. In further embodiments, an immunosuppressive agent is also administered to the subject.