New application of dicaffeoylquinic acid

A technology of caffeoylquinic acid and uses, applied in the field of medicine for preparing brain neuroprotective agents

Inactive Publication Date: 2010-02-10
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the use of dicaffeoylquinic acid as a neuroprotective agent, nor has 1,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid Relevant reports on dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid and other dicaffeoylquinic acid used alone or in combination

Method used

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  • New application of dicaffeoylquinic acid
  • New application of dicaffeoylquinic acid
  • New application of dicaffeoylquinic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 compound of the present invention

[0030] Erigeron breviscapus (Vant.) Hand.-Mazz. Medicinal material (removing weeds), percolation with 60L of 95% ethanol and 20L of 70% ethanol respectively, and vacuum decompression to recover ethanol. Ethyl acetate layer extract, normal pressure silica gel column chromatography and reversed phase C18 column chromatography repeated purification can obtain 1,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid.

[0031] The four compounds of the present invention can also be derived from commercially available varieties, such as 1,5-dicaffeoylquinic acid (Zhongshan Kangzhiyuan Biotechnology Co., Ltd.), 4,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid Caffeoylquinic acid (Shijiazhuang Yanfeng Pharmaceutical Technology Co., Ltd.) and 3,4-dicaffeoylquinic acid are self-made with a purity greater than 95%.

Embodiment 2

[0032] Embodiment 2 The preparation of drug injection of the present invention

[0033]Take 1,5-dicaffeoylquinic acid 5g, 4,5-dicaffeoylquinic acid 5g, 3,4-dicaffeoylquinic acid 5g, 3,5-dicaffeoylquinic acid 5g, chlorine Sodium chloride 85g, sodium sulfite 2g, dissolved in water for injection, made into 10000ml, subpackaged into 3mg / 2ml / branch injection, intermediate detection, potting, sterilization, labelling.

Embodiment 3

[0034] Embodiment 3 The preparation of drug injection of the present invention

[0035] Take 1,5-dicaffeoylquinic acid 5g, 4,5-dicaffeoylquinic acid 50g, 3,4-dicaffeoylquinic acid 50g, 3,5-dicaffeoylquinic acid 50g, chlorine Sodium chloride 85g, sodium sulfite 2g, dissolved in water for injection, made into 10000ml, subpackaged into 3mg / 2ml / branch injection, intermediate detection, potting, sterilization, labelling.

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PUM

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Abstract

The invention provides an application of dicaffeoylquinic acid for the preparation of drugs of cerebral neuroprotection and the drugs can be used for curing ischemic strokes. The invention also provides a drug composite of cerebral neuroprotection. Drug effect tests and researches show that dicaffeoylquinic acid component is a new kind of effective ingredients which can protect cerebral nerve better, can both promote the survival of cerebral cortical neurons in vitro and the antioxidation and has a certain function of passing blood-brain barrier.

Description

technical field [0001] The invention relates to a new application of dicaffeoylquinic acid, in particular to the application in the preparation of medicines for protecting brain nerves, which belongs to the field of medicine. Background technique [0002] Apoplexy, also known as apoplexy, is characterized by sudden fainting, hemiplegia, crooked tongue, awkward speech or numbness in one side of the body, and has the characteristics of rapid onset and rapid change. Disease is a common and frequently-occurring disease among middle-aged and elderly people, which seriously threatens the survival and health of human beings. This disease is equivalent to Ischemic Cerebral vascular Disease (ICVD) in Western medicine, also known as ischemic stroke, which has a high mortality rate and disability rate, and seriously threatens human health and life safety ( Rao Mingli, Lin Shihe. Cerebrovascular Diseases. People's Health Publishing House, 2002.172). As a common and frequently-occurrin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P25/00A61P9/10
Inventor 张艺孟宪丽张静
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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