Pharmaceutical composition for improving cognitive impairment and preparation method thereof

A technology for functional impairment and improving cognition, applied in the field of pharmaceutical compositions and their preparation, can solve problems such as difficulty in obtaining satisfactory results, and achieve the effects of improving cognitive dysfunction, reducing costs, and having fewer types

Active Publication Date: 2020-10-30
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For diseases such as AD and VD, it is difficult to achieve satisfactory results with single-target therapy

Method used

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  • Pharmaceutical composition for improving cognitive impairment and preparation method thereof
  • Pharmaceutical composition for improving cognitive impairment and preparation method thereof
  • Pharmaceutical composition for improving cognitive impairment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0052] Preparation Example 1-Scutellaria baicalensis extract

[0053] The preparation method of Scutellaria baicalensis extract of the present invention is:

[0054] (A) Scutellaria baicalensis coarse powder was decocted and extracted with 10 times the weight of water and 8 times the weight of water respectively, each extraction was 60 minutes, filtered and the two filtrates were combined to obtain the Scutellaria baicalensis extract.

[0055] (B) Adjust the pH value of the Scutellaria baicalensis extract to 1 with 2 mol / L hydrochloric acid, react at 80° C. for 30 minutes, and centrifuge after cooling down to obtain the first precipitate and the first clear liquid.

[0056] (C) the first precipitate is mixed with 2 times the volume of water to obtain a mixed solution; the mixed solution is adjusted to a pH value of 7 with 40wt% sodium hydroxide solution, then an equal volume of dehydrated alcohol is added, filtered to obtain the second Precipitate and Second Clear.

[0057]...

preparation example 2

[0059] Preparation example 2-gardenia extract I

[0060] (1') Boil and extract the gardenia coarse powder with water as a solvent, extract 3 times in total, each time use 10 times the weight of water, each 10-15min, merge 3 times and boil the extract to obtain the gardenia extract;

[0061] (2') filtering the gardenia extract to obtain a filtrate and a filter residue; concentrating the filtrate to obtain a concentrated solution;

[0062] (3') Slowly add absolute ethanol to the concentrated solution under stirring, and use absolute ethanol to prepare a solution with a concentration of 70 wt% alcohol concentration, then leave it at 0-10°C to obtain a supernatant, and the supernatant The solution was concentrated to obtain Gardenia extract I.

[0063] After testing, the content of geniposide in the obtained gardenia extract I was 12wt%.

preparation example 3

[0064] Preparation Example 3-Gardenia Extract II

[0065] (1") Extract the gardenia coarse powder with 75vol% ethanol solution at 20-35°C, extract 3 times in total, use 10 times the weight of 75vol% ethanol solution each time, 8h each time, combine 3 times for leaching Extract the solution to obtain the gardenia extract;

[0066] (2") Filtering the Gardenia extract to obtain a filtrate and a filter residue; concentrating the filtrate to obtain a concentrate; drying the concentrate to obtain Gardenia Extract II.

[0067] After testing, the content of geniposide in the obtained gardenia extract II is 15 wt%.

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Abstract

The invention discloses a pharmaceutical composition for improving cognitive impairment and a preparation method thereof. The pharmaceutical composition is prepared from the following components in parts by weight: 1-6 parts of a scutellaria baicalensis extract, 2-8 parts of a gardenia extract and 3-12 parts of pig gall powder. The pharmaceutical composition provided by the invention can improve cognitive impairment and has few types of raw materials.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for improving cognitive dysfunction and a preparation method thereof. Background technique [0002] Cognition is the process in which the human brain receives external information, processes it, and converts it into internal mental activities, thereby acquiring knowledge or applying knowledge. It includes aspects such as memory, language, visuospatial, executive, calculation and comprehension judgments. Cognitive dysfunction refers to the impairment of one or more of the above-mentioned cognitive functions and affects the individual's daily or social ability. When two or more of the above-mentioned cognitive domains are affected and affects the individual's daily or social ability dementia can be diagnosed. [0003] Senile dementia (Alzheimer's disease, AD) is a central nervous system degenerative disease mainly charac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61P25/28A61K35/413
CPCA61K36/539A61K36/744A61K35/413A61P25/28A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 程发峰王雪茜孔慧王庆国
Owner BEIJING UNIV OF CHINESE MEDICINE
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