Composition for enhancing cognitive function, composition for remedying anxiety symptoms, and composition for suppressing cerebral atrophy

A technology for improving cognition and composition, which is applied in the field of composition for improving cognitive function, and can solve problems such as decline in physical function, insufficient prevention or improvement of cognitive function decline, difficulty in exercising, etc.

Pending Publication Date: 2020-10-30
AJINOMOTO CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, dietary intake of some of the above components does not have sufficient preventive or ameliorating effects on cognitive decline, and many components require future validation of effectiveness
[0011] In addition,

Method used

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  • Composition for enhancing cognitive function, composition for remedying anxiety symptoms, and composition for suppressing cerebral atrophy
  • Composition for enhancing cognitive function, composition for remedying anxiety symptoms, and composition for suppressing cerebral atrophy
  • Composition for enhancing cognitive function, composition for remedying anxiety symptoms, and composition for suppressing cerebral atrophy

Examples

Experimental program
Comparison scheme
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specific example

[0127] Specific examples include: salts with inorganic bases, salts with organic bases, salts with inorganic acids, salts with organic acids, salts with amino acids, and the like.

[0128] Examples of salts with inorganic bases include salts with alkali metals such as lithium, sodium, potassium and the like; salts with alkaline earth metals such as magnesium, calcium and the like; ammonium salts and the like.

[0129] Examples of salts with organic bases include salts with alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, etc.; salts with heterocyclic amines such as morpholine, piperidine, etc., and the like.

[0130] Examples of salts with inorganic acids include salts with hydrohalic acids (hydrochloric acid, hydrobromic acid, hydroiodic acid, etc.), sulfuric acid, nitric acid, phosphoric acid, etc., and the like.

[0131] Examples of salts with organic acids include salts with monocarboxylic acids such as formic acid, acetic acid, propionic acid, etc....

Embodiment 1

[0247] [Example 1] Composition for improving cognitive function

[0248] The ingredients were weighed and mixed in given amounts so as to provide the composition shown in Table 1, and the composition for improving cognitive function of Example 1 (hereinafter referred to as "the composition of Example 1") was prepared. Similarly, a composition having the composition ratio shown in Table 1 was prepared and used as Comparative Example 1.

[0249] [Table 1]

[0250]

experiment example 1

[0251] [Experimental example 1] Study on the effect on learning function and memory function

[0252] C57Bl / 6j aged mice (58 to 61 weeks old, male) (purchased from Charles River Laboratories, Japan) were used to study the effects of the compositions of Example 1 and Comparative Example 1 on learning and memory functions.

[0253] As shown in Table 2, C57Bl / 6j aged mice were divided into 4 groups (n=12 / group). Only the vehicle (NPD+Veh.) was administered to the group which ad libitum intake of normal protein feed (containing 20 wt% casein). The other 3 groups were allowed to ingest low-protein feed (containing 5 wt% casein) freely, and these 3 groups were used as a group administered with only the vehicle (LPD+Veh.), a group administered with the composition of Example 1, respectively. (LPD+E1) and the group administered with the composition of Comparative Example 1 (LPD+C1). In LPD+E1 and LPD+C1, 1 g / kg body weight of the composition (E1) of Example 1 and the composition (C1...

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PUM

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Abstract

The present invention provides a composition for enhancing cognitive function, a composition for remedying anxiety symptoms, and a composition for suppressing cerebral atrophy, which are highly safe and can be continuously ingested or administered. The compositions contain one or more selected from the group consisting of 25 mol% to 45 mol% of leucine and 20 mol% to 40 mol% of phenylalanine relative to the total content of leucine, lysine, valine, isoleucine, phenylalanine, histidine, and tryptophan.

Description

technical field [0001] The present invention relates to a composition for improving cognitive function, a composition for improving anxiety-like symptoms and a composition for inhibiting brain atrophy. Background technique [0002] With the recent rapid increase in the elderly population, the number of dementia patients has rapidly increased, and it was reported that the proportion of dementia population reached 8.4% of the population over 65 years old in 2015. [0003] According to the definition of the Ministry of Health, Labor and Welfare of Japan, dementia is defined as "a state in which various mental functions normally developed after birth slowly decline and disappear to the extent that daily life and social life cannot be managed". [0004] Dementia includes dementia caused by various diseases such as Alzheimer's type dementia, frontotemporal dementia (Pick's disease, etc.), Lewy body dementia, and cerebrovascular dementia. Although advancing age is the greatest ris...

Claims

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Application Information

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IPC IPC(8): A61K31/198A23L33/175A61K31/405A61K31/4172A61P25/22A61P25/28
CPCA61K31/405A61P25/22A23L33/175A61P25/28A61K31/198A61K31/4172A61K2300/00A23V2002/00A23V2250/0628A23V2250/063A23V2250/0654A23V2250/0626A23V2250/0638A23V2250/0624A23V2250/065A23V2200/322
Inventor 佐藤英明安居昌子安达祐介铃木克也高田理浩
Owner AJINOMOTO CO INC
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