Dietary supplement for improving memory

A dietary supplement and memory-improving technology, applied in the fields of application, food science, food ingredients, etc., to maintain the activity of nerve cells, improve long-term memory and procedural memory, and learning performance without obvious side effects

Inactive Publication Date: 2019-07-26
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, observing the effects of these drugs in treating AD, it is found that none of the drugs can effectively treat AD, and they all only alleviate the symptoms of dementia to a certain extent and delay the progression of the disease.

Method used

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  • Dietary supplement for improving memory
  • Dietary supplement for improving memory
  • Dietary supplement for improving memory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 A dietary supplement for improving memory

[0032] The specific formula of the dietary supplement of the present embodiment:

[0033] 40% neuropeptide, 5% trace elements and vitamins, 20% unsaturated fatty acid and 35% additives, wherein the neuropeptide is composed of EVGEIE, QKQLQ, LERNAIKKVGK and TEPGLE in a ratio of 1:1:1:1.

[0034] The cells used in the experiment are mouse cerebral cortex neural stem cells. Fetal mouse cerebral cortex tissue from the 14-15 day old mouse embryo was cut into soybean size with sterile surgical instruments, filtered through a 200-mesh stainless steel screen, and planted in Culture flask, 37°C, 5% CO 2 Cultivate, after 5-7 days, after the formation of the primary clone, passage by mechanical separation method, blow through a pipette, filter with a 200-mesh stainless steel screen, centrifuge at 800r / min for 10min, discard the supernatant, add fresh neurosphere culture medium, and use a pipette Repeated pipetting carefully t...

Embodiment 2

[0038] Embodiment 2 A kind of preparation method of dietary supplement tablet for improving memory

[0039] The dietary supplement of this embodiment includes: 50% neuropeptide, 5% trace elements and vitamins, 15% unsaturated fatty acid and 30% additives. The neuropeptide is composed of EVGEIE, Composed of QKQLQ, LERNAIKKVGK and TEPGLE.

[0040]With 1.2mm sieve, 50kg of the above-mentioned mixture powder is sieved into the stainless steel cylinder, and mixed with a tumbling mixer at a mixing speed of 6rpm for 10 minutes, and 1kg of magnesium stearate is sieved into the stainless steel cylinder of the above-mentioned mixture with the 1.2nm sieve. Subsequently, all the granules were mixed with a tumbling type mixer at a mixing speed of 4 rpm for 5 minutes to obtain a dietary supplement mixture.

[0041] The resulting blend was compressed on a tablet press at a compression speed of about 60,000 tablets / hour, using round, biconvex punches with a diameter of 11 mm.

[0042] The c...

Embodiment 3

[0044] The preparation of embodiment 3 tablet coatings:

[0045] A coating was made on the tablets in Example 2.

[0046] The following ingredients were mixed with a propeller mixer to form a film coating suspension:

[0047] 17.5kg titanium acetate cellulose (30% aqueous solution);

[0048] 0.44kg talcum powder;

[0049] 0.621kg titanium dioxide;

[0050] 1.059kg triethyl citrate.

[0051] The tablets were coated with the film coating suspension in a drum coater to a final weight of 420 mg / tablet. Coated tablets may be polished with beeswax or paraffin. In this way, a film-coated white tablet with the following parameters is obtained (all performance test methods are carried out according to the Chinese Pharmacopoeia):

[0052] Average weight: 420±15mg;

[0053] Disintegration: <30min;

[0054] Brittleness: <1%.

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PUM

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Abstract

A dietary supplement for improving memory comprises, by weight, the following components: 30-50% of neuropeptide, 2-5% of trace elements, 10-20% of vitamins, unsaturated fatty acids and 25-60% of auxiliaries, wherein a peptide preparation comprises peptides with the following sequences: eVGEIE, QKQLQ, LERNAIKKVGK and TEPGLE. The dietary supplement is easy to absorb, has no obvious side effect, cankeep the activity of nerve cells and protect the nerve cells from aging-related injury, is used for preventing, ameliorating or combating defects associated with aging processes, activating memory-related brain mechanisms, improving long-term and programmed memory, learning performance and attention, and maintaining a healthy spirit during aging.

Description

technical field [0001] The invention belongs to the field of dietary supplements, in particular to a dietary supplement for improving memory. Background technique [0002] With the development of the economy, the overall living standard of the people has been greatly improved, and the life expectancy of the people has generally been extended, and at the same time, the development speed of the aging of our society has been accelerated. [0003] my country has entered an aging society as early as 1999, and the elderly population is increasing year by year. According to the results of the sixth national census in 2010, the number of elderly people aged 60 or above reached 178 million, accounting for 13.26% of the total population. In 2050, there will be 451 million people over the age of 60 in my country. The increase in the global aging population has led to an increase in the number of patients with Alzheimer's disease. The United States has carried out a forecast study on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/12A23L33/15A23L33/155A23L33/16A23L33/18
CPCA23L33/12A23L33/15A23L33/155A23L33/16A23L33/18A23V2002/00A23V2200/302A23V2200/322A23V2250/1584A23V2250/1586A23V2250/1588A23V2250/1592A23V2250/1598A23V2250/1608A23V2250/1612A23V2250/1616A23V2250/1626A23V2250/1628A23V2250/1636A23V2250/1642A23V2250/1868A23V2250/187A23V2250/1872A23V2250/1874A23V2250/702A23V2250/704A23V2250/708A23V2250/71A23V2250/161A23V2250/1634A23V2250/5432
Inventor 朱剑虹王帆魏乃礼钟俊杰
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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