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Method of determining sepsis in the presence of blast flagging

A technology of blast cells and sepsis, which is applied to the data, instruments and applications of laboratory analysis, and can solve the problems of no longer effective treatment and deterioration of patients.

Pending Publication Date: 2020-11-24
BECKMAN COULTER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

During the time required to complete routine diagnostic testing, the patient's condition may deteriorate, possibly to the point where the patient requires special clinical support or can no longer be effectively treated

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  • Method of determining sepsis in the presence of blast flagging
  • Method of determining sepsis in the presence of blast flagging
  • Method of determining sepsis in the presence of blast flagging

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Embodiment Construction

[0036] Diagnostic markers for sepsis have been studied for many years. Even so, there are still no definitive diagnostic tests or biomarkers available to determine sepsis. It was previously thought that a panel of seven blood cell-related factors could be examined to identify possible septic infection. See, eg, Park et al, "Screening of sepsis using leukocyte cell population data from the Coulter automatic blood cell analyzer DxH800," International Journal of Laboratory Hematology, 2011, 33, 391-399 at 397-98. As early as a few years ago, it was recognized that a calculated parameter or index based on at least two of seven factors was needed for septic infection prediction. The present inventors have determined that the onset of a possible septic infection can be predicted by a simple and efficient comparison with cut-off values, without the need for formulas to calculate parameters or to use indicators of parameters. These comparisons can include the use of the standard dev...

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Abstract

Embodiments of the present disclosure may allow for an efficient and accurate way or system to assess whether an individual has sepsis, including an individual who may exhibit symptoms or clinical criteria similar to inflammation. Embodiments include using a laboratory test that may be routinely ordered. Embodiments of the present invention may allow for the diagnosis of sepsis even when some cells show an abnormal size. Often, when white blood cells show a likelihood of an abnormal size, a "blast flag" in a system is triggered to warn a user that the sample may warrant further analysis. Unexpectedly, the diagnosis of sepsis status using standard deviation of monocyte volume may be more accurate when considering whether a blast flag has been triggered. Based on the sepsis status, treatmentmay be started quickly, thereby preventing complications, including organ failure and death, of not treating sepsis fast enough.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 685,753, entitled "METHOD OF DETECTING SEPSIS IN THEPRESENCE OF BLAST FLAGGING," filed June 15, 2018, the entire contents of which are incorporated herein by reference. [0003] The subject matter of this application is related to PCT Patent Application No. PCT / US17 / 14708, filed January 24, 2017, entitled "Infection Detection and Differentiation Systems and Methods," which claims the Benefit of U.S. Provisional Patent Application No. 62 / 288,091, entitled "Infection Detection and Differentiation Systems and Methods." This application is also related to U.S. Provisional Application No. 62 / 660,795, filed April 20, 2018, entitled "Sepsis Infection Detection Systems and Methods." The contents of these applications are hereby incorporated by reference for all purposes. Background technique [0004] Sepsis is an uncontrolled systemic inflammatory r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G01N33/50
CPCG01N33/5091G01N33/5094A61B5/412G01N15/1031G01N2800/26G01N33/56972G16H10/40G01N33/48735G01N2015/1402G01N15/0656G01N33/49G01N2015/016
Inventor 戴安娜·B·卡雷亚加罗伯特·T·马加里利利阿纳·M·特吉多妮科尔·卡皮奥
Owner BECKMAN COULTER INC