Flupentixol melitracen microsphere and preparation method thereof

A technology of flupentixol and melitracen, applied in the field of medicine, can solve the problems of complex preparation process of microspheres, and achieve the effects of improving sustained release effect, increasing drug loading and simple preparation process

Active Publication Date: 2020-11-27
SHENZHEN SCIENCARE MEDICAL INDUSTRIES CO. LTD.
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] However, the microsphere preparation process is complicated: the emulsification-solvent evaporation method usually requires the use of an organic solvent and an aqueous solution containing an emulsifier to prepare a single or double emulsion, stirring and volatilizing to remove the organic solvent, and washing the emulsifier during the collection of the microspheres. , and finally through vacuum drying or freeze drying to get the final product

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  • Flupentixol melitracen microsphere and preparation method thereof
  • Flupentixol melitracen microsphere and preparation method thereof
  • Flupentixol melitracen microsphere and preparation method thereof

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Embodiment Construction

[0045]The present invention will be further described below in conjunction with specific embodiments, and the advantages and characteristics of the present invention will become clearer along with the description. However, these embodiments are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0046] 1.1 Preparation of microspheres by single emulsion method

[0047] Dissolve a certain amount of main drug and polylactide in dichloromethane to obtain an oil phase, inject it into a high-speed stirring (7000rpm) outer water phase polyvinyl alcohol solution, volatilize for 4 hours, centrifuge to discard the outer water ph...

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Abstract

The invention relates to the technical field of medicines, in particular to flupentixol melitrexed microspheres and a preparation method thereof. The flupentixol melitrexine microsphere comprises flupentixol hydrochloride, melitrexine hydrochloride and a polyester material. The flupentixol melitrexine microsphere has the advantages of being free of organic solvents, simple in preparation process,high in drug loading capacity, remarkable in slow release effect and capable of being used for long-acting injection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to flupenthixol melitracen microspheres and a preparation method thereof. Background technique [0002] Flupentixol-melitracen contains two components: flupentixol and melitracen. Flupenthixol exerts antipsychotic effects by antagonizing dopamine D2 receptors in the brain. Melitracen is a tricyclic antidepressant, including antagonism of reserpine, anti-compulsive stupor, and enhancement of epinephrine and NA. The combination of flupenthixol and melitracen can increase the content of various neurotransmitters such as DA, NV and 5-HT in the synaptic gap in the brain, thereby regulating the function of the central nervous system, and is suitable for neurasthenia, chronic fatigue syndrome, depression or anxiety neurosis, cardiac or gastrointestinal neurosis, autonomic dysfunction, and various depressive and anxiety states; also used for nervous headache, migraine, tension headache, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/16A61K47/34A61P25/28A61P39/00A61P25/00A61P25/24A61P25/22A61P25/06A61P25/02A61K31/135
CPCA61K9/0019A61K9/1647A61K31/135A61K31/496A61P25/00A61P25/02A61P25/06A61P25/22A61P25/24A61P25/28A61P39/00
Inventor 梁铮林颜携国王实强曲伟张涛
Owner SHENZHEN SCIENCARE MEDICAL INDUSTRIES CO. LTD.
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