Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Flupentixol melitracen microsphere and preparation method thereof

A technology of flupentixol and melitracen, applied in the field of medicine, can solve the problems of complex preparation process of microspheres, and achieve the effects of improving sustained release effect, increasing drug loading and simple preparation process

Active Publication Date: 2020-11-27
SHENZHEN SCIENCARE MEDICAL INDUSTRIES CO. LTD.
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the microsphere preparation process is complicated: the emulsification-solvent evaporation method usually requires the use of an organic solvent and an aqueous solution containing an emulsifier to prepare a single or double emulsion, stirring and volatilizing to remove the organic solvent, and washing the emulsifier during the collection of the microspheres. , and finally through vacuum drying or freeze drying to get the final product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Flupentixol melitracen microsphere and preparation method thereof
  • Flupentixol melitracen microsphere and preparation method thereof
  • Flupentixol melitracen microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0045]The present invention will be further described below in conjunction with specific embodiments, and the advantages and characteristics of the present invention will become clearer along with the description. However, these embodiments are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0046] 1.1 Preparation of microspheres by single emulsion method

[0047] Dissolve a certain amount of main drug and polylactide in dichloromethane to obtain an oil phase, inject it into a high-speed stirring (7000rpm) outer water phase polyvinyl alcohol solution, volatilize for 4 hours, centrifuge to discard the outer water ph...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical field of medicines, in particular to flupentixol melitrexed microspheres and a preparation method thereof. The flupentixol melitrexine microsphere comprises flupentixol hydrochloride, melitrexine hydrochloride and a polyester material. The flupentixol melitrexine microsphere has the advantages of being free of organic solvents, simple in preparation process,high in drug loading capacity, remarkable in slow release effect and capable of being used for long-acting injection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to flupenthixol melitracen microspheres and a preparation method thereof. Background technique [0002] Flupentixol-melitracen contains two components: flupentixol and melitracen. Flupenthixol exerts antipsychotic effects by antagonizing dopamine D2 receptors in the brain. Melitracen is a tricyclic antidepressant, including antagonism of reserpine, anti-compulsive stupor, and enhancement of epinephrine and NA. The combination of flupenthixol and melitracen can increase the content of various neurotransmitters such as DA, NV and 5-HT in the synaptic gap in the brain, thereby regulating the function of the central nervous system, and is suitable for neurasthenia, chronic fatigue syndrome, depression or anxiety neurosis, cardiac or gastrointestinal neurosis, autonomic dysfunction, and various depressive and anxiety states; also used for nervous headache, migraine, tension headache, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/16A61K47/34A61P25/28A61P39/00A61P25/00A61P25/24A61P25/22A61P25/06A61P25/02A61K31/135
CPCA61K9/0019A61K9/1647A61K31/135A61K31/496A61P25/00A61P25/02A61P25/06A61P25/22A61P25/24A61P25/28A61P39/00
Inventor 梁铮林颜携国王实强曲伟张涛
Owner SHENZHEN SCIENCARE MEDICAL INDUSTRIES CO. LTD.
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com