Drug discovery method and device based on relationship extraction and knowledge reasoning and computer equipment

A technology of relation extraction and knowledge reasoning, applied in electrical digital data processing, natural language data processing, instruments, etc., can solve problems such as high cost, inability to find potential drugs well, and achieve the effect of avoiding high cost and low recall

Pending Publication Date: 2020-12-01
PING AN TECH (SHENZHEN) CO LTD
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Problems solved by technology

[0005] The main purpose of this application is to provide a drug discovery method, device and computer equipment based on relational extraction and kn

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  • Drug discovery method and device based on relationship extraction and knowledge reasoning and computer equipment
  • Drug discovery method and device based on relationship extraction and knowledge reasoning and computer equipment
  • Drug discovery method and device based on relationship extraction and knowledge reasoning and computer equipment

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Embodiment Construction

[0062] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present application, and are not intended to limit the present application.

[0063] refer to figure 1 , the embodiment of the present application provides a drug discovery method based on relational extraction and knowledge reasoning, which involves the field of artificial intelligence, including steps:

[0064] S1. Use the preset relationship extraction model to perform entity-pair relationship extraction on natural sentences containing substance-gene entity pairs or gene-disease entity pairs, and obtain the relationship types of substance-gene entity pairs and gene-disease entity pairs;

[0065] S2. Calculate the first possibility score of the s...

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Abstract

The invention relates to artificial intelligence, and discloses a drug discovery method and device based on relationship extraction and knowledge reasoning and computer equipment. The method comprisesthe steps of obtaining a relation type of a substance-gene entity pair and a gene-disease entity pair through a relation extraction model, and calculating a first possibility score of a substance targeting gene according to the relation type of the substance-gene entity pair; calculating a second likelihood score of the gene as a target gene of the disease according to the relationship type of the gene-disease entity pair; calculating a third likelihood score of the substance as a therapeutic substance for the disease. The relationship extraction model may be stored in a blockchain. Accordingto the method, substance-gene and gene-disease relationship types are automatically extracted from massive medical literatures, and knowledge is utilized to reasoning substances with treatment effects or potential treatment effects of the drugs, so that high cost and low recall of a scheme based on structural property similarity of the compounds are avoided, and more substances with potential curative effects can be obtained.

Description

technical field [0001] This application relates to the field of artificial intelligence, in particular to a drug discovery method, device and computer equipment based on relational extraction and knowledge reasoning. Background technique [0002] The main technology of assisting drug development is to discover or find substances that have curative or potential therapeutic effects on diseases to support the subsequent drug development process. At present, the technology of drug discovery mainly uses the similarity of the chemical structure and properties of pharmacological substances to discover new drugs. This method needs to rely on high-quality and knowledge-rich knowledge bases of chemical structures, properties, and interactions, and the construction cost is extremely high, and The newly researched knowledge and properties of many compounds cannot be used. [0003] Another main idea for new drug development is to automatically mine the therapeutic relationship between s...

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Application Information

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IPC IPC(8): G16C20/70G06F40/279
CPCG16C20/70G06F40/279Y02A90/10
Inventor 张圣顾大中
Owner PING AN TECH (SHENZHEN) CO LTD
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