Method for screening glioma biomarker based on PTEN gene state

A biomarker, PTEN-WT technology, applied in the field of molecular biology technology and computer, can solve the problems of heterogeneity and inefficiency
CN112071365APending Publication Date: 2020-12-11BEIJING INSTITUTE OF TECHNOLOGYGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING INSTITUTE OF TECHNOLOGYGY
Publication Date
2020-12-11

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Abstract

The invention provides a method for screening a glioma biomarker based on a PTEN gene state. The method comprises the following steps of: (1) obtaining the PTEN gene states of glioma patients; (2) dividing the glioma patients into a PTENWT subgroup and a PTENmutant subgroup; (3) screening subgroup-specific DEGs for the patients of the subgroups respectively; (4) fitting the subgroup-specific DEGswith the survival time of the subgroup patients to obtain subgroup-specific OPRDEGs; (5) constructing a risk score of each subgroup patient, observing the relationship between the risk score and the malignant degree of the tumor, and predicting the survival rate of each subgroup patient; (6) screening OPRDEGs of independent prognosis of each subgroup; and (7) screening potential targeting drugs. The independent optimal prognostic gene of the PTEN mutation subgroup with high malignant degree is analyzed through multi-factor COX, and further guiding significance is provided for diagnosis, prognostic prediction and treatment of PTEN mutation glioma.
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Description

technical field

[0001] The invention relates to the field of molecular biology technology and computer, and relates to a method for screening glioma biomarkers based on PTEN gene status. Background technique

[0002] Glioma is the most common adult primary brain tumor. Glioma is classified into astrocytoma, oligodendroglioma, and ependymoma according to its histological manifestations. The World Health Organization (WHO) classifies gliomas as Divided into I, II, III and IV grades, the higher the grade, the stronger the invasiveness. Grade IV gliomas, glioblastoma multiforme (GBM), are the most aggressive and high-grade malignant tumors. The 1- and 5-year overall survival rates for high-grade gliomas are 40% and 10%, respectively. The high mortality rate of glioma is due to its aggressiveness and high recurrence rate. The heterogeneity of gliomas did not improve patient survival despite treatment with surgery, radiotherapy, and alkylating chemotherapy. Major advances in g...

Claims

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