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Ibuprofen granule and preparation method thereof

A technology of granules and fillers, which is applied in the field of drug preparation, can solve problems such as undisclosed dissolution rate, and achieve the effects of good fluidity, high dissolution rate, and simple and easy production process

Pending Publication Date: 2020-12-29
HARBIN PHARMA GROUP TECH CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The granules use dextrin, hydroxypropyl cellulose and sodium cyclamate as excipients, only considering that the excipients do not contain sugar, but it does not appear to solve the problem of dissolution

Method used

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  • Ibuprofen granule and preparation method thereof
  • Ibuprofen granule and preparation method thereof
  • Ibuprofen granule and preparation method thereof

Examples

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Effect test

Embodiment 1

[0019] prescription ingredients Dosagekg effect ibuprofen 20 raw material lactose 53.75 filler microcrystalline cellulose 15 filler silica 1 Glidant Carboxymethyl Starch Sodium 5 disintegrant aspartame 0.25 sweetener Povidone K30 5 Adhesive

[0020] The preparation method is to carry out according to the following steps:

[0021] 1. Jet milling: put the ibuprofen raw material in a jet mill for jet milling to obtain the pulverized raw material.

[0022] 2. Screening: Weigh according to the batch prescription, premix silicon dioxide, carboxymethyl starch sodium, aspartame, and microcrystalline cellulose, and pass through 100 meshes of premixed auxiliary materials, lactose and micropowdered ibuprofen Sieve, set aside.

[0023] 3. Mixing: Put the sieved material in a three-dimensional motion mixer and mix for 20 minutes.

[0024] Four, the preparation of adhesive (10% weight povidone K30): take the povidon...

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Abstract

The present invention discloses an ibuprofen granule and a preparation method thereof, relates to the field of medicine preparation, and aims at providing the ibuprofen granule and the preparation method thereof. The ibuprofen granule is good in taste, rapid in granule disintegration, high in dissolution rate, high in bioavailability and convenient to take clinically, and the preparation method issimple in processes, controllable in quality and also suitable for industrial production. The ibuprofen granule consists of the following components in percentages by weight: 20.0% of ibuprofen, 60.0-70.0% of a filler, 4.0-5.0% of an adhesive, 4.0-5.0% of a disintegrating agent, 1.0-2.0% of a flow aid and 0.1-0.5% of a sweetening agent. The granule prepared by adopting the formula and the methodis good in uniformity and stability, low in related substances, high in dissolution rate and high in bioavailability, and the preparation technology is convenient and feasible, low in cost, free of any special devices and suitable for industrial production. The ibuprofen granule and the preparation method thereof are applied to the field of medicine preparation.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to an ibuprofen granule and a preparation method thereof. Background technique [0002] Ibuprofen, 2-methyl-4-(2-methylpropyl)phenylacetic acid, named by IUPAC: 2-(4-isobutylphenyl)propanoic acid, CAS No.15687-27-1, molecular formula C 13 h 18 o 2 , molecular weight 206.28. Non-steroidal anti-inflammatory drugs (NSAIDs) have analgesic, anti-inflammatory, and antipyretic effects. Reduce the sensitivity of peripheral nerve pain, produce analgesic and anti-inflammatory effects; and play an antipyretic effect through the hypothalamic thermoregulation center. [0003] The application number is 201510049631.7, which discloses ibuprofen granules and its preparation method in the Chinese patent application. The granule adopts auxiliary materials of sucrose and sodium aracycline to improve the taste, and the dissolution rate is not high, which shows that the dissolution rate of sampl...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/192A61K47/04A61K47/26A61K47/38A61K47/32A61P29/00
CPCA61K31/192A61K9/1635A61K9/1623A61K9/1652A61K9/1611A61P29/00
Inventor 徐岩杨新春张道旭杨景杰贺亮张天雪黄炎何欢尹涛吴娜高蔷薇纪洪姣戴旭东王晓颖张译文
Owner HARBIN PHARMA GROUP TECH CENT
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