Unlock instant, AI-driven research and patent intelligence for your innovation.

Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery

A technology of melanocortin receptor and melanocortin, which is used in medical preparations, pharmaceutical formulas, peptides and other directions containing active ingredients

Pending Publication Date: 2021-01-05
PALATIN TECH INC
View PDF14 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to date, the use of MClr-specific compounds for the treatment of UC, Crohn's disease or IBD has been limited to systemic routes of administration, such as disclosed in International Publication No. WO 2016 / 066702, PCT / EP 2015 / 075019

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery
  • Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery
  • Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0062] 1.0 Definition.

[0063] Before proceeding to the description of the present invention, certain terms are defined as set forth herein.

[0064] In the sequences given for the peptides according to the invention, the amino acid residues have their conventional meanings, such as Manual of Patent Examining Procedure [Handbook of Patent Examining Procedures] 9th Edition given in Chapter 2400. Thus, "Nle" is norleucine, "Asp" is aspartic acid, "His" is histidine, "Phe" is phenylalanine, "Arg" is arginine, and "Trp" is tryptophan acid, and "Lys" is lysine, etc. It is understood that the D-isomer is designated by "D-" followed by the three letter code or amino acid designation such that, for example, D-Phe is D-phenylalanine. Amino acid residues not covered by the foregoing include the following amino acids or amino acid side chains, it being understood that such amino acid residues may be L-isomers or D-isomers:

[0065]

[0066]

[0067]

[0068] The term "al...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

Disclosed are formulations, compositions and methods for delivery of melanocortin receptor-specific peptides, particularly cyclic peptides selective and specific for the melanocortin-1 receptor, to the lumen of the gastrointestinal tract for treatment of melanocortin receptor-mediated or responsive diseases, indications, conditions and syndromes of the gastrointestinal tract.

Description

[0001] Cross References to Related Applications [0002] This application claims the title "Melanocortin Receptor-Specific Peptide Formulations and Methods for Gastrointestinal Tract-Specific Delivery" filed on March 23, 2018 ]”, the specification and claims of which are incorporated herein by reference. [0003] sequence listing [0004] This application contains a Sequence Listing that has been filed electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on March 18, 2019, is named 1903-187-Sequence_ST25.txt and is 40KB in size. Background technique [0005] Field of the invention (technical field): [0006] The present invention relates to melanocortin receptor-specific peptides, particularly cyclic peptides that are selective and specific for the melanocortin-1 receptor, and methods, compositions and formulations comprising such peptides for gastrointestinal Tract-specific delivery, including colon-specific deli...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61P43/00C07K7/64A61K38/33A61K38/12
CPCA61P43/00A61K38/12C07K7/64A61K9/4825A61K9/4891A61K9/2846A61K9/1635A61K38/34A61K9/2027A61K9/0053A61P29/00A61P1/00A61K9/4808A61K9/4866A61K38/22
Inventor 约翰·哈罗德·多德斯蒂芬·夸库·多度诺
Owner PALATIN TECH INC