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Metabolism improving agent

A technology for improving agents and metabolic abnormalities, applied in metabolic diseases, pill delivery, testing pharmaceutical preparations, etc., can solve problems that have not been used to analyze the mechanism of visceral fat accumulation

Pending Publication Date: 2021-01-08
UNIVERSITY OF THE RYUKYUS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this model was proposed for the study of acidosis, and has not been used to analyze the mechanism that causes visceral fat accumulation, or to evaluate the mechanism and drugs that inhibit visceral fat accumulation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0072] By the following method, it is investigated whether an obesity model can be produced by improving the diet of a casein high-load rat model (Ann.Nutr.Metab., 50, p.299, 2006). The above-mentioned casein high-load rat model is Predatory model of a high-protein diet capable of reproducing the condition of acidosis.

[0073] Prior to this, McCarty (McCarty MF. Acid-base balance may influence risk forinsulin resistance syndrome by modulating cortisol output. Med. Hypotheses 64:380-384, 2005) has reported that acidosis promotes the production of glucocorticoids, Cushing syndrome It is considered that visceral obesity and the conversion enzyme 11β-HSD1 to the active substance of glucocorticoids are related to the accumulation of visceral fat. Therefore, in order to clarify the point of action based on the above, we used The human adrenocortical carcinoma cell line of the target cell was adjusted, and the pH of the culture solution was adjusted so that the environment around th...

example 2

[0081] Using the model rats of the present invention prepared in Example 1 (13LK was used as a feed and fed freely for a week), the metabolism-improving action of citrate was confirmed by the following method. An aqueous solution containing citrate (aqueous solution containing 370 mg of potassium citrate and 312 mg of sodium citrate hydrate in 100 mL) was prepared, and the above-mentioned model rats were given drinking water for one week (administration group: 13LK+K / Na Cit), compared with the non-administration group (13LK). Within one week, there was no change in body weight between the administration group and the non-administration group ( Figure 6 (a)).

[0082] In the same manner as in Example 1, changes in various biochemical parameters were confirmed. As a result, in the administration group, urine pH and blood pH increased, and blood HCO 3 - and BE also rises ( Figure 6 (c) and (d)). Furthermore, in the administration group, not only the glucocorticoid (cortico...

example 3

[0089] Using the model rats of the present invention prepared in Example 1 (using 13LK as a feed, experiencing a week of free feeding), using citrate or sodium bicarbonate as an alkalizing agent to administer, confirm the urine pH and urine The results are shown in Table 3. Urinary pH increased and corticosterone excretion decreased in both the citrate-administered and sodium bicarbonate-administered groups compared with the control group.

[0090] [table 3]

[0091]

[0092] ＊ p＊＊ p＊＊＊ p<0.0001vs 13LK (Dunnet test)

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PUM

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Abstract

Provided is a metabolism improving agent that comprises an alkalizer such as an acidosis ameliorating agent or a urine alkalizer as an active ingredient and has effects of improving insulin resistance, improving pituitary and adrenal functions, reducing visceral fat accumulation, etc.

Description

technical field [0001] The present invention relates to a metabolism-improving agent capable of improving insulin resistance, improving pituitary and adrenal gland functions, and reducing visceral fat accumulation. Background technique [0002] In recent years, the increase of obesity and visceral fat caused by the Westernization of diet, and the accompanying lifestyle diseases (hypertension, hyperlipidemia, diabetes, hyperuricemia, etc.) The increase of syndromes has become a social problem, and the financial burden on medical care is rapidly increasing. [0003] Although the cause of people's obesity caused by diet mainly lies in the excessive intake of fat and protein, it can be considered that the mechanisms by which they cause visceral fat accumulation are different from each other, and it is conceivable that in the actual obesity pathology, the two are complicated. intertwined together. [0004] For example, in the case of visceral fat accumulation due to excessive f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A23L33/10A61K31/194A61K33/10A61P3/00A61P3/04A61P3/06A61P3/10A61P5/00A61P5/04A61P5/12A61P5/46G01N33/15G01N33/50
CPCA61K31/194A61P3/00A61P3/04A61P3/06A61P3/10A61P5/00A61P5/04A61P5/12A61P5/46A23L33/16A23L33/10C40B30/06A61K33/00A23L29/015A23L29/03A61K2300/00A23L33/30A61K9/20A61K31/225A61K33/10A61K47/22
Inventor 益崎裕章中村英生平井利武原薫神田贵史山崎里美小林正西冈浩一郎
Owner UNIVERSITY OF THE RYUKYUS
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