Method and application for inhibiting breast cancer cell proliferation and tumor growth by using YPB peptide
A technology of FITC-TAT-GGG-YPB and peptides, which is applied in the field of inhibiting breast cancer cell proliferation and tumor growth and application by using YPB peptides, can solve the problem that the role of YY1 is not clear enough, and achieve the effect of low toxicity or side effects
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specific Embodiment approach 1
[0042] Embodiment 1: In this embodiment, a YPB peptide segment has a sequence of P-P-R-K-K-K-R-K-H-R-L-W-A-A-H-C-R-K-I-Q-L-K-K-D-G-S-S.
specific Embodiment approach 2
[0043] Specific embodiment two: the application of the YPB peptide in this embodiment, the YPB peptide is synthesized with TAT and GGG, and then labeled with fluorescent FITC to obtain the FITC-TAT-GGG-YPB polypeptide; the FITC-TAT-GGG - The YPB polypeptide is used to suppress the combination of YY1 and EZH2, thereby inhibiting the proliferation of breast cancer cells and the growth of tumors.
specific Embodiment approach 3
[0044] Embodiment 3: The difference between this embodiment and Embodiment 2 is that the sequence of the FITC-TAT-GGG-YPB polypeptide is FITC-YGRKKRRQRRR-GGG-PPRKKKRKHRLWAAHCRKIQLKKDGSS.
[0045] Other steps are the same as in the second embodiment.
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