A kind of production technology of lactitol crystal

A production process, lactitol technology, applied in the field of lactitol production process crystals, can solve the problems of low lactitol content, difficult to increase yield, inconsistent operation, etc., achieve catalyst dosage optimization, reduce production costs, and simplify the process Effect

Active Publication Date: 2021-10-22
何定兵
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The primary crystallization yield of lactitol in this process is 42.5% to 48%, and the secondary crystallization needs to be purified by simulated moving bed chromatography, and the process is complex
Chinese invention application CN 110818752 A discloses a production process of lactitol, which discloses a production method of lactitol, adding lactose to deionized water to form a lactose solution, after adjusting the pH, adding a quantitative catalyst, at high temperature Carry out hydrogenation reaction under high pressure, obtain lactose hydrogenation liquid, obtain lactitol solution after removing catalyst, lactitol solution obtains lactitol crystal after purification, concentration, crystallization, oven dry again, but it has the following problems: (1), lactitol The crystallization operation methods of hydrogenation liquid, primary mother liquid, secondary mother liquid, third mother liquid, and fourth mother liquid are different, and the operation is not uniform, which brings certain troubles to operators; (2) Lactitol content requirements (3) The crystallization process is mainly a single-factor crystallization process of cooling, and compared with the multi-factor crystallization process, the process is relatively backward

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  • A kind of production technology of lactitol crystal
  • A kind of production technology of lactitol crystal
  • A kind of production technology of lactitol crystal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: (Constant temperature evaporation and crystallization above 78°C without cooling down)

[0063] (1) if figure 1 As shown, 1800.0 kg of lactose was added to deionized water to form an aqueous solution of lactose with a mass percent concentration of 50.0% (that is, lactose refraction). The lactose content was 99.0%. Food-grade sodium carbonate was used to adjust the pH to 7.55, and 2% of lactose mass was added. Raney nickel catalyst, set the hydrogenation temperature at 110°C, the hydrogen pressure at 8.0-10MPa, react for 3.0h, and discharge the material into a settling tank to obtain lactose hydrogenation liquid; the discharge pipeline passes through a tank filled with RO water (the interior is a coil structure ) about 5 square meters, that is, the temperature of the hydrogenation solution is lowered, and the temperature of the RO water is also raised to above 70°C. That's it.

[0064] (2) The hydrogenated lactitol solution was settled in the first settling ...

Embodiment 2

[0077] Example 2 (evaporative crystallization at 77°C, crystallization tank at 79°C)

[0078]1) Add 1,800.0 kg of lactose into RO water (after heat exchange with lactulose hydrogenation solution, temperature 78° C.) to form an aqueous solution of lactose with a mass percent concentration of 56.0% (i.e. lactose refraction, concentration), with a lactose content of 98.5%. Use sodium carbonate aqueous solution (30%) to adjust the pH to 7.8, add a Raney nickel catalyst with a lactose mass of 3.2%, set the hydrogenation temperature to 115 ° C, and the hydrogen pressure to 8.8 MPa, react for 2.5 hours, and discharge the material to a settling tank to obtain lactose hydrogenation liquid;

[0079] (2) The lactitol hydrogenated solution was settled in the first settling tank for 2 hours, the upper layer hydrogenated solution was put into the second settling tank, and settled for 1.5 hours again to obtain the lactitol hydrogenated solution; the index of the lactitol solution is: lactito...

Embodiment 3

[0087] Example 3 (evaporative crystallization above 78°C)

[0088] (1) Add 1800.0 kg of lactose into RO water (after heat exchange with lactulose hydrogenation solution, temperature 75° C.) to prepare an aqueous solution of lactose with a mass percent concentration of 57.5% (i.e. lactose refraction), with a lactose content of 99.0%. Sodium carbonate aqueous solution (30%) adjusts the pH to 7.9, adds a Raney nickel catalyst with a lactose mass of 3.5%, sets the hydrogenation temperature to 110°C, and the hydrogen pressure to 8.0MPa, reacts for 2.5 hours, and discharges the material to a sinker to obtain a lactose hydrogenation solution .

[0089] (2) The lactitol hydrogenated solution was settled in the first settling tank for 2 hours, the upper layer hydrogenated solution was put into the second settling tank, and settled for 1.5 hours again to obtain the lactitol hydrogenated solution; the index of the lactitol solution is: lactitol purity 98.6% , lactitol refraction 57.0%, ...

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Abstract

The invention discloses a production process of lactitol crystals, which comprises the following steps: (1) performing a hydrogenation reaction on a lactose aqueous solution under the action of a catalyst to obtain a lactose hydrogenated liquid; (2) removing the catalyst in the lactose hydrogenated liquid to obtain a lactitol solution ; separation, concentration, and crystallization to obtain lactitol anhydrous crystals or lactitol monohydrate crystals; in step (2), the crystallization is carried out at 78-98°C and under a negative pressure not higher than -0.08MPa Crystallization by evaporation. Through the process of the present invention, the first crystallization yield of lactitol relative to the lactose raw material reaches 50.0% to 65%, and the total yield of anhydrous lactitol relative to the lactose raw material dry weight reaches more than 90%, and the process is simplified at the same time , easy production operation, low production cost, and the same operation can also obtain lactitol monohydrate only by changing the temperature.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a production process crystal of lactitol. Background technique [0002] Lactitol α (actitol), also known as lactitol, chemical name 4-0-β-D-galactopyranose ~ D-sorbitol. There are three main forms of crystalline lactitol: lactitol anhydrous, lactitol monohydrate, and lactitol dihydrate. The main uses of lactitol are as follows: (1) Excellent healthy sweetener and prebiotic. Lactitol is mainly produced from lactose in milk. It is natural and healthy. Its sweetness is similar to that of sucrose, and its sweetness is 30% to 40% of that of sucrose. , jam, jelly, table sweetening and so on. In addition, lactitol can efficiently proliferate intestinal probiotics, regulate intestinal health, and can be used in health care products and pharmaceutical excipients. Moreover, it does not increase blood sugar after eating, and can be used as a sweetener for diabetics. (2) Lac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H1/00C07H1/06C07H15/04
CPCC07H1/00C07H1/06C07H15/04
Inventor 何定兵
Owner 何定兵
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