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A bioactive dressing with anti-inflammatory and hemostatic functions

A bioactive and functional technology, applied in the field of medical materials, can solve the problems of insoluble salicylic acid in water and limit the wide application of salicylic acid, and achieve rapid hemostasis and healing, prolonged action time and effect, and safe use. Effect

Active Publication Date: 2021-08-10
GUANGZHOU TOWE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, salicylic acid is poorly soluble in water, which greatly limits the wide application of salicylic acid in various aqueous formulations, especially hydrogel formulations.

Method used

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  • A bioactive dressing with anti-inflammatory and hemostatic functions
  • A bioactive dressing with anti-inflammatory and hemostatic functions
  • A bioactive dressing with anti-inflammatory and hemostatic functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 bioactive dressing 1

[0046] First, according to the mass parts of raw materials, 8.0 parts of hydroxymethyl chitosan, 7.0 parts of sodium alginate, 8.0 parts of Artemisia argyi leaf extract, 3.0 parts of menthol, 1.5 parts of calcium chloride and 5.0 parts of glycerin were added to an appropriate amount. In ionized water, fully stir and dissolve on a shaker at 150-200rpm at 4°C to obtain mixed solution A; add 6.0 parts of β-cyclodextrin and 2.0 parts of salicylic acid to an appropriate amount of deionized water, and ultrasonically treat for 3-5 minutes, 70 Heat and stir at ℃ for 1.5 hours to fully dissolve salicylic acid and β-cyclodextrin, mix well to obtain clathrate solution, freeze-dry to obtain clathrate powder; add the clathrate powder obtained into mixed solution A, Thoroughly stir on a shaker at 150-200rpm to obtain a mixed solution B; spread the mixed solution B on a film, freeze-dry it in a freeze dryer for 24 hours, and steri...

Embodiment 2

[0047] The preparation of embodiment 2 bioactive dressing 2

[0048] Except not adding menthol, all the other component contents and operating conditions are identical with embodiment 1.

Embodiment 3

[0049] The preparation of embodiment 3 bioactive dressing 3

[0050] Except that the mass parts ratio of chitosan in embodiment 1 is changed into 5.0 parts, the mass parts ratio of sodium alginate is changed into 10.0 parts and the mass parts ratio of menthol is changed into 1.0 parts, all the other composition contents and operating conditions are constant.

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Abstract

The invention discloses a biologically active dressing with anti-inflammatory and hemostatic functions and a preparation method thereof. The dressing includes, for example, 5.0-10.0 parts of chitosan, 5.0-10.0 parts of sodium alginate, 5.0-15.0 parts of hemostatic drugs, 1.0-3.0 parts of salicylic acid and 1.0-10.0 parts of β-cyclodextrin. The dressing realizes controllable release of salicylic acid, reduces skin irritation and toxic and side effects of salicylic acid; in addition, the present invention realizes rapid hemostasis and wound healing through the synergistic effect of hemostatic drugs, menthol and salicylic acid. Healing effect, rich raw materials and low production cost, can be widely used in the treatment of small bleeding wounds.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a bioactive dressing with anti-inflammatory and hemostatic functions, a preparation method and an application thereof. Background technique [0002] Traditional wound dressings such as cotton gauze and non-woven fabrics have been widely used in the past, however, due to their easy sticking to the wound site, it is easy to cause secondary trauma at the wound site when changing or removing the dressing, and poor barrier It is easy to cause bacterial infection of the wound, and has no obvious healing effect on the wound surface. Therefore, there is an urgent need for a dressing that effectively blocks external germs and has ideal wound healing and antibacterial effects. [0003] Chitosan-based dressings are a kind of natural biomacromolecular materials, which have many excellent biomaterial properties, so they have been continuously used as dressings in the me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/20A61L15/18A61L15/40A61L15/42A61L15/44A61K31/722A61K31/734A61K31/60A61K31/045A61K36/258A61K36/282A61K36/898A61K36/489A61K36/14A61K36/28A61K36/74A61K47/02A61K47/10A61K47/36A61K47/69A61P7/04A61P17/02A61P31/02A61P17/04
CPCA61K31/045A61K31/60A61K31/722A61K31/734A61K36/14A61K36/258A61K36/28A61K36/282A61K36/489A61K36/74A61K36/898A61K47/02A61K47/10A61K47/36A61L15/18A61L15/20A61L15/28A61L15/40A61L15/42A61L15/44A61L2300/21A61L2300/232A61L2300/236A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2300/602A61L2400/04A61K47/6951A61P7/04A61P17/02A61P17/04A61P31/02A61K2300/00C08L5/08C08L5/04C08L5/16
Inventor 罗宇仙
Owner GUANGZHOU TOWE BIOTECH CO LTD
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