Drug-loaded punctiform stent

A drug-loaded, point-like technology, used in stents, medical science, prostheses, etc., can solve problems such as chronic injury and inflammation, and achieve the effect of easy intravascular re-intervention, reduction of metal load and fracture, and short length.

Pending Publication Date: 2021-02-23
SHANDONG RIENTECH MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although stenting improves acute PTA outcomes, stenting has also been shown to cause ch...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Ni (54.55-57)%Ti alloy material is selected as the matrix, drawn into a capillary metal tube, and laser-engraved into a bare stent.

[0029] (2) Treat the surface of the stent matrix to remove oxides and surface residues. The specific steps include: a) placing the stent under a microscope to remove residues and remove residual burrs; b) placing the stent on the Wash in nitric acid solution or hydrofluoric acid solution, the concentration of nitric acid solution is about 10%~30%, the concentration of hydrofluoric acid solution is about 3%~5%, and clean at room temperature for 20-120 seconds; c) in acetone, Ultrasonic cleaning in a mixture of absolute ethanol and deionized water for 10 minutes; put the cleaned stent into absolute ethanol for later use.

[0030] (3) Perform electrochemical corrosion treatment on the stent matrix; place the stent matrix in the electrolyte for electrochemical corrosion, nickel-titanium alloy as the anode, platinum / 316L stainless steel as...

Embodiment 2

[0034] (1) Ni (54.55-57)%Ti alloy material is selected as the matrix, drawn into a capillary metal tube, and laser-engraved into a bare stent.

[0035] (2) Treat the surface of the stent matrix to remove oxides and surface residues. The specific steps include: a) placing the stent under a microscope to remove residues and remove residual burrs; b) placing the stent on the Wash in nitric acid solution or hydrofluoric acid solution, the concentration of nitric acid solution is about 10%~30%, the concentration of hydrofluoric acid solution is about 3%~5%, and clean at room temperature for 20-120 seconds; c) in acetone, Ultrasonic cleaning in a mixture of absolute ethanol and deionized water for 10 minutes; put the cleaned stent into absolute ethanol for later use.

[0036] (3) Perform electrochemical corrosion treatment on the stent matrix; place the stent matrix in the electrolyte for electrochemical corrosion, nickel-titanium alloy as the anode, platinum / 316L stainless steel as...

Embodiment 3

[0040] (1) Ni (54.55-57)%Ti alloy material is selected as the matrix, drawn into a capillary metal tube, and laser-engraved into a bare stent.

[0041] (2) Treat the surface of the stent matrix to remove oxides and surface residues. The specific steps include: a) placing the stent under a microscope to remove residues and remove residual burrs; b) placing the stent on the Wash in nitric acid solution or hydrofluoric acid solution, the concentration of nitric acid solution is about 10%~30%, the concentration of hydrofluoric acid solution is about 3%~5%, and clean at room temperature for 20-120 seconds; c) in acetone, Ultrasonic cleaning in a mixture of absolute ethanol and deionized water for 10 minutes; put the cleaned stent into absolute ethanol for later use.

[0042] (3) Perform electrochemical corrosion treatment on the stent matrix; place the stent matrix in the electrolyte for electrochemical corrosion, nickel-titanium alloy as the anode, platinum / 316L stainless steel as...

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PUM

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Abstract

The invention discloses a drug-loaded punctiform stent and a preparation method. The drug-loaded punctiform stent is mainly used for an interlayer after a subknee artery balloon dilatation molding operation. The drug-loaded punctiform stent comprises a short nickel-titanium alloy stent base body, the stent base body is of a self-expanding grid design structure, the surface of the stent base body is provided with uniform drug-loading micro-pits, and the surfaces of the uniform drug-loading micro-pits are coated with drug coatings. The preparation method comprises the steps that (1), a nickel-titanium alloy is processed into the stent base body, (2), the surface of the stent base body is treated; (3), corrosion treatment is carried out on the stent base body; (4), the corroded stent base body is cleaned; and (5), drug coating is carried out on the surface of the stent base body with the micro-pits. According to the drug-loaded punctiform stent, the shorter longitudinal length is combinedwith the opening design, so that the metal load on artery blood vessels is reduced to the greatest extent, the surface area in contact with the artery blood vessels is reduced, the drug-loaded punctiform stent is not prone to breaking and adapts to various blood vessel diameters, and coated drugs on the surface of the drug-loaded punctiform stent can be controlled to release; and the stent base body gives full play to supporting and drug treatment effects, and the occurrence rate of restenosis and target lesion blood supply reconstruction can be reduced.

Description

technical field [0001] The invention relates to a drug-loaded point-shaped support and a preparation method thereof, belonging to the technical field of implantable medical devices. Background technique [0002] Chronic severe lower limb ischemia (Chronic limb-threatening ischemia, CLTI) is often associated with inferior knee artery disease, and for Rutherford grade 5 and 6 ischemia, the reconstructed inferior knee artery patency is related to whether the wound can heal and whether the patient can avoid major amputations , thereby reducing the death caused by limb ischemia. A recent meta-analysis of 9399 plain old balloon angioplasty (POBA) in 6769 cases showed that the 1-year primary patency rate was 63.1%, and the major amputation rate was 14.9%. Although this result has been significantly improved compared with 10 years ago, it is still unable to obtain satisfactory clinical efficacy, so many clinical studies have focused on the patency of the inferior knee artery. With...

Claims

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Application Information

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IPC IPC(8): A61F2/90
CPCA61F2/90A61F2240/001A61F2310/00023A61F2250/0067
Inventor 张海军周广泰周超
Owner SHANDONG RIENTECH MEDICAL TECH
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