A kind of biodegradable transparent liquid polyester that can be quickly photocured with mercapto crosslinking agent and preparation method and application

A sulfhydryl crosslinking agent, light curing technology, applied in the direction of prosthesis, additive processing, medical science, etc., can solve the problems of obstruction, limited application, affecting the crosslinking rate, etc., to increase the curing thickness, good biocompatibility , the effect of material transparency

Active Publication Date: 2022-08-09
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Degradable photocurable materials generally modify or functionalize degradable polymer materials. The most common method is to modify the carbon-carbon double bond on the material to endow the material with photocurable function, but the crosslinking of the double bond usually produces free base, there is a certain degree of cytotoxicity, and the cross-linking will be hindered by oxygen, which will affect the cross-linking rate and limit the application in the deeper biomedical field

Method used

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  • A kind of biodegradable transparent liquid polyester that can be quickly photocured with mercapto crosslinking agent and preparation method and application
  • A kind of biodegradable transparent liquid polyester that can be quickly photocured with mercapto crosslinking agent and preparation method and application
  • A kind of biodegradable transparent liquid polyester that can be quickly photocured with mercapto crosslinking agent and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A preparation method of a biodegradable transparent liquid polyester that can be quickly photocured with a thiol crosslinking agent, comprising the following steps:

[0045] The first step, 4-methylcyclohexanone is a raw material, and 3-chloroperoxybenzoic acid is oxidized to obtain transparent liquid monomer 4-methylcaprolactone:

[0046] Dissolve 60.00g of 4-methylcyclohexanone in 100ml of dichloromethane, in an ice-water bath, dropwise at a constant speed into 500ml of dichloromethane solution containing 120.00g of 3-chloroperoxybenzoic acid, after the dropwise addition, The reaction was carried out at room temperature for 24 h, the solid was removed by suction filtration, washed with saturated aqueous sodium thiosulfate, sodium bicarbonate, and sodium chloride successively, and distilled under reduced pressure to obtain 4-methylcaprolactone (MeCL), a transparent liquid monomer. figure 1 4-methylcaprolactone prepared in the first step in the biodegradable transparent...

Embodiment 2

[0063] A preparation method of a biodegradable transparent liquid polyester that can be quickly photocured with a thiol crosslinking agent, comprising the following steps:

[0064] The first step, 4-methylcyclohexanone is a raw material, and 3-chloroperoxybenzoic acid is oxidized to obtain transparent liquid monomer 4-methylcaprolactone:

[0065] Dissolve 60.00g of 4-methylcyclohexanone in 100ml of dichloromethane, and in an ice-water bath, add it dropwise to 500ml of dichloromethane solution containing 120.00g of 3-chloroperoxybenzoic acid at a constant speed. The reaction was continued for 24 h, the solid was removed by suction filtration, washed with saturated aqueous sodium thiosulfate, sodium bicarbonate, and sodium chloride successively, and distilled under reduced pressure to obtain 4-methylcaprolactone (MeCL), a transparent liquid monomer.

[0066] The second step, transparent liquid polymer poly(4-methylcaprolactone) BDM-PMCL 50 The preparation method comprises the f...

Embodiment 3

[0073] A preparation method of a biodegradable transparent liquid polyester that can be quickly photocured with a thiol crosslinking agent, comprising the following steps:

[0074] The first step, 4-methylcyclohexanone is a raw material, and 3-chloroperoxybenzoic acid is oxidized to obtain transparent liquid monomer 4-methylcaprolactone:

[0075] Dissolve 60.00g of 4-methylcyclohexanone in 100ml of dichloromethane, and in an ice-water bath, add it dropwise to 500ml of dichloromethane solution containing 120.00g of 3-chloroperoxybenzoic acid at a constant speed. The reaction was continued for 24 h, the solid was removed by suction filtration, washed with saturated aqueous sodium thiosulfate, sodium bicarbonate, and sodium chloride successively, and distilled under reduced pressure to obtain 4-methylcaprolactone (MeCL), a transparent liquid monomer.

[0076] The second step, transparent liquid polymer poly(4-methylcaprolactone) BDM-PMCL 100 The preparation method comprises the ...

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Abstract

The invention discloses a biodegradable transparent liquid polyester that can be quickly photocured with a mercapto crosslinking agent. The structure is as follows: x+y is 10-100, and theoretically x=y. The invention also discloses a fast photocurable transparent polyester photocurable mixed solution prepared from the biodegradable transparent liquid polyester. The transparent polyester light-curing mixed solution of the invention adopts liquid alkynyl-terminated modified poly(4-methylcaprolactone) as the main material, which has both good biocompatibility and biodegradability of polycaprolactone , and because of the liquid properties at room temperature, the light curing does not require any solvent, achieves zero VOC standards, and the material is transparent, which can smoothly penetrate the curing light.

Description

technical field [0001] The invention belongs to the field of photocurable polymer materials, in particular to a biodegradable transparent liquid polyester with good biocompatibility that can be quickly photocured with a thiol crosslinking agent, and a preparation method and application. Background technique [0002] Light-curing material is a curing molding material developed based on light-curing technology. Due to its simple molding and curing method, it has a very wide range of applications in the fields of coatings, dentistry, adhesives, microelectronics and biomaterials. With the promulgation of sustainable development policies and the gradual transfer of photocurable materials to high value-added industries such as biomedicine, traditional acrylate and epoxy photosensitive resins have been unable to meet the requirements, so biodegradable photocurable materials have been widely used. s concern. [0003] Biodegradable polymer materials are generally divided into two ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/91C08G63/02C08G63/08C08J3/24C08L67/04A61L27/18B33Y70/00
CPCC08G63/91C08G63/912C08G63/02C08G63/08C08J3/24A61L27/18B33Y70/00C08J2367/04C08L67/04
Inventor 肖艳郎美东王照闯
Owner EAST CHINA UNIV OF SCI & TECH
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