The invention discloses a multifunctional drug storage box. The multifunctional drug storage box comprises a box cover and a box body, wherein one side of the box cover is connected with one side of the box body through a pin shaft, a layer of goldenrod paper is arranged on the inner surface of the box cover, a circle of groove is formed in the upper end face of the lateral wall of the box body, a seal ring is arranged in the groove, the groove in the box body is covered by the edge of the box cover, an inner cavity of the box body is divided into an upper part and a lower part by a drug pad, the drug pad is connected with the box body in a detachable mode, a plurality of partition boards which are mutually connected in a clamping mode are transversely and longitudinally arranged on the drug pad in a crossing mode, the partition boards are connected with the drug pad in a detachable mode, the top portion of each partition board is lower than the top portion of the lateral wall of the box body, and a pull type drawer which can be drawn out from the lateral side of the box body is arranged on the portion, below the drug pad, of the inner cavity of the box body. The multifunctional drug storage box has the advantages that the shading effect is good, drugs can be placed in the storage box in a classified mode, cross infection caused by stacking of the drugs is avoided, reutilization is available, cost of the drugs is greatly reduced, and medicine burden of patients is reduced.