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Medicine for treating depression by acting on glossopharyngeal and vagus nerve regulation CCK peptide as well as preparation method and use method of medicine

A technology for vagus nerve and depression, applied in the preparation of sugar derivatives, drug combinations, pharmaceutical formulations, etc., can solve problems such as uneasy inner feelings, development of depressive diseases and treatment difficulties, and achieve low cost, good cognition and brain protection. Activity, the effect of improving cognition and cerebral protective activity

Inactive Publication Date: 2021-03-12
杨浚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The depression of the vagus nerve leads to long-term depression and depression of the patient. The dysfunction of the vagus nerve makes the inner feelings uneasy, depresses the heart, and the heart receptors are disturbed. The brain strengthens the inner feelings again and again in cognition, forming a vicious circle. Difficult to develop and treat depressive disorders

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Preparation of polygala glycoside

[0023]Polygala tenuifolia (Polygala tenuifolia Willd.), as one of the medicinal materials with the same source of medicine and food in the past dynasties, is known as "the key medicine for nourishing life". Insomnia, dreaminess, forgetfulness, palpitations, trance, coughing up phlegm, sore swelling, breast swelling and pain, etc. The dosage of Polygala root in the 2015 edition of the Chinese Pharmacopoeia is 3-10g. The clinically effective dosage of Polygala root in mice is 1.5g / 10kg, and the dosage of Polygala crude drug that causes adverse reactions in mice is 4g / kg, which is equivalent to human ( 60kg) the effective dose of the crude drug and the adverse reaction crude drug dose were 90g and 240g respectively. Polygala saponin has hemolytic effect: the hemolytic index of Polygala saponin was 2926, the whole Polygala hemolytic index was 2585, the Polygala heart hemolytic index was 4300, and the purified Polygala saponin ...

Embodiment 2

[0027] Example 2: Toxicity Test of Polygala Glycosides

[0028] 1. Acute toxicity test

[0029] ①Acute toxicity test by intragastric administration in mice

[0030] Kunming mice were gavaged with 150g of polygala glucoside obtained in Example 1 / kg body weight, and no death or abnormal poisoning reactions occurred in the animals, which is equivalent to the maximum clinical dosage per day (the standard of "Chinese Pharmacopoeia" 2015 edition is 3-10g) 900 times. That is to say, the maximum tolerated dose of polygala polygala glycosides is determined to be above 150 g crude drug / kg body weight.

[0031] ②Acute toxicity test of intraperitoneal injection in mice

[0032] Kunming mice were intraperitoneally injected with polygala glycoside 50g crude drug / kg body weight, and none of the animals died or had abnormal poisoning reactions, which was equivalent to 300 times the maximum clinical daily dose for humans (the standard in the 2015 edition of the Chinese Pharmacopoeia was 3-1...

Embodiment 3

[0034] Example 3: Preparation of Polygala Glucoside Glossopharyngeal Spray

[0035] Get the polygala glycoside 1kg that embodiment 1 obtains, add surfactant 8-10g, add honey to 1.2kg. Blend grinding. According to the second appendix of "Chinese Pharmacopoeia" 2015 edition: the viscosity measured by Ping's viscometer is between 10 centipoise and 15 centipoise, and it is filled in a spray bottle (standard spray pump 0.05ml thread 18 / 415 German Pfeiffer Company China Department) Medium, tighten the hand pump, and spray. The FMA laser granulometer was selected for on-line measurement of the fog droplets, which complied with the requirements of the 2015 edition of the Chinese Pharmacopoeia. Quantitative 20ml, 50ml, 100ml / bottle filling; packaging leaves the factory. That is, the preparation of the polygaloside glossopharyngeal spray of the present invention has been completed.

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PUM

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Abstract

The invention discloses a medicine for treating depression by acting on a glossopharyngeal and vagus nerve regulation CCK peptide. The medicine contains a polygala tenuifolia glycoside compound or medicinal salt, ester or solvate of the polygala tenuifolia glycoside compound. The medicine is prepared into a tongue-throat spray or / and a buccal preparation (tablets and liquid) for administration. The medicine is directly contacted with and absorbed by vagus nerves of coated tongue, pharynx and larynx of the oral cavity, hypothalamus-pituitary-adrenal axis (HPA axis) dysfunction of the vagus nerves is regulated through CCK neuropeptide, and the remarkable effect of safely, quickly and efficiently treating depression with low cost is achieved.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular, the invention relates to a drug that acts on the glossopharyngeal vagus nerve to regulate CCK peptide to treat depression. Background technique [0002] According to the latest statistics from the World Health Organization, in 2020, depression will become the second largest disease in the world, and severe functional disability will rise to the first place in the general category of diseases, second only to ischemic heart disease in terms of death. Due to the complex pathological mechanism of depression, and the unsatisfactory treatment effect of existing antidepressants, large side effects, and easy recurrence, once suffering from depression, it is difficult to heal for life, causing great economic and psychological burdens on families and society. At present, the incidence of depression in the world is about 53.1%, while in developed countries it is close to 60%, and the preval...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P25/24A61P25/28C07H1/00C07H13/04
CPCA61K31/7024A61P25/24A61P25/28C07H1/00C07H13/04
Inventor 杨浚
Owner 杨浚
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