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Anti-hair loss and hair growth uses of rebamipide

A technology for rebamipide and its use, which is applied in the field of rebamipide in the preparation of anti-hair loss and hair growth preparations. It can solve the problems of rebamipide that have not been publicly reported in the literature, and achieve a good mental state, maintenance of hair follicles, and balanced metabolism. Effect

Active Publication Date: 2022-01-18
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no literature publicly reporting the application of rebamipide in hair loss and hair growth

Method used

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  • Anti-hair loss and hair growth uses of rebamipide
  • Anti-hair loss and hair growth uses of rebamipide
  • Anti-hair loss and hair growth uses of rebamipide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Efficacy evaluation experiments rebamipide for C57BL / 6 mice natural germinal

[0039] 1. Experimental Animals

[0040]Experimental animals were male C57BL / J6,8 weeks old, weighing 18-20g, purchased at relatively Yangzhou University Medical Center. C57BL / 6 mice reared under normal conditions, a temperature of 25 ± 2 ℃, 50% -70% humidity, 12h light and dark each alternately, food and water freely available, corn cob litter changed every two days, and let it adjust 7 days after the start of the experiment rearing environment.

[0041] 2. pharmacy

[0042] 4% chloral hydrate: 0.4g chloral hydrate was dissolved in 10ml of physiological saline, the centrifugal vortex until completely dissolved to prepare a solution of 4% chloral hydrate.

[0043] Topical Cream 2.1 4% (O / W) rebamipide, a drug made from the following materials:

[0044] 400 parts by weight Laid rebamipide, 1000 parts by weight of stearic acid, 200 parts by weight glyceryl stearate, 200 parts by w...

Embodiment 2

[0058] Example 2: Efficacy evaluation experiments rebamipide for C57BL / 6 mouse model of chemotherapy alopecia

[0059] 1. Experimental Animals

[0060] Experimental animals were male C57BL / J6,8 weeks old, weighing 18-20g, purchased at relatively Yangzhou University Medical Center. C57BL / 6 mice reared under normal conditions, a temperature of 25 ± 2 ℃, 50% -70% humidity, 12h light and dark each alternately, food and water freely available, corn cob litter changed every two days, and let it adjust 7 days after the start of the experiment rearing environment.

[0061] 2. pharmacy

[0062] 4% chloral hydrate configuration supra.

[0063] Rebamipide ointment configuration above.

[0064] Rebamipide oral suspension configuration as above.

[0065] Cyclophosphamide for Injection: 0.2g cyclophosphamide dissolved in 20ml of physiological saline, the centrifugal vortex until completely dissolved to prepare a 10mg / ml solution.

[0066] 3. Chemotherapy hair loss model

[0067] After t...

Embodiment 3

[0078] Example 3: rebamipide for C57BL / 6 mice efficacy evaluation of androgenic alopecia Model

[0079] 1. Experimental Animals

[0080] Experimental animals C57BL / J6,8 weeks old, weighing 18-20g, purchased at relatively Yangzhou University Medical Center. C57BL / 6 mice reared under normal conditions, a temperature of 25 ± 2 ℃, 50% -70% humidity, 12h light and dark each alternately, food and water freely available, corn cob litter changed every two days, and let it adjust 7 days after the start of the experiment rearing environment.

[0081] 2. pharmacy

[0082] 4% chloral hydrate configuration supra.

[0083] Rebamipide ointment configuration above.

[0084] Rebamipide oral suspension configuration as above.

[0085] Injection of testosterone propionate (1mL: 25mg, BAIYUNSHAN Ming-Pharmaceutical Co., Ltd.), when diluted with oil to 1mg / ml. Testosterone propionate was diluted with diluted vortex mixer for 2 minutes shaking, it was thoroughly mixed for use.

[0086] 3.Aga mou...

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Abstract

The invention provides a use of rebamipide and its physiologically acceptable salt or solvate in the preparation of a skin application composition and the further application of the skin application composition in pharmaceutical preparations, cosmetics, care products, beauty products in the application. The skin application composition and further applied preparations can comprehensively and effectively target various causes of hair loss, thereby more helping to balance the metabolic state of the subject in need, adjust its mental state to achieve better treatment, care synergy, and The active ingredient of rebamipide has high safety and few side effects, so it has broad application prospects in the fields of pharmaceutical preparations, cosmetics, nursing products, beauty products and the like.

Description

Technical field [0001] The present invention belongs to the field of preparation of compounds and, particularly, to the art of preparing rebamipide prevention of hair loss, hair growth formulation purposes, and further used in drug, cosmetic, care, cosmetics or the like. Background technique [0002] Hair loss refers to hair loss phenomenon. The process of metabolism in normal subjects Metro is also accompanied by hair loss and new life, is a normal phenomenon metabolism of organisms. Normal shedding of hair is in hair catagen and telogen, catagen and due to the entry into the growing new hair constantly in dynamic equilibrium, it can maintain the normal amount of hair. However, pathological hair loss, is due to various reasons, or pressure, or stay up late, or endocrine disorders and other reasons, caused by abnormal hair shedding phenomenon. Hair loss often have an impact on the human spirit, as in recent years, an increasingly competitive society, the incidence of hair loss is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/438A61P17/14A61P37/02A61P17/00A61K8/49A61Q7/00
CPCA61K31/438A61P17/14A61P37/02A61P17/00A61K8/4926A61Q7/00
Inventor 吴亮蔡磊钱洪发冯陈杰蔡溪云弋吴舒婷董昊郝园园陈佳敏刘宙吴晓明
Owner CHINA PHARM UNIV
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