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A kind of highly active component PMMA-based bone cement that can be cured rapidly and its preparation method and application

A fast-curing, high-activity technology, applied in the field of medical materials, can solve the problems that PMMA bone cement cannot have good biological activity and mechanical properties at the same time, and the curing time is long, so as to shorten the curing time, enhance the mechanical properties and improve the biological activity. Effect

Active Publication Date: 2021-11-16
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the defects and deficiencies that the existing PMMA bone cement cannot have good biological activity and mechanical properties at the same time, and the curing time is long, and provide a fast-curable high-activity component PMMA-based bone cement , by using higher molecular weight P(MMA-co-MPS), increasing the amount of hydroxyapatite modified by P(MMA-co-MPS), improving the bone cement preparation steps, the prepared PMMA bone cement not only It has good mechanical properties and biological activity, and shortens the curing time

Method used

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  • A kind of highly active component PMMA-based bone cement that can be cured rapidly and its preparation method and application
  • A kind of highly active component PMMA-based bone cement that can be cured rapidly and its preparation method and application
  • A kind of highly active component PMMA-based bone cement that can be cured rapidly and its preparation method and application

Examples

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Embodiment 1

[0044] A kind of PMMA-based bone cement with high active components that can be cured rapidly, including solid phase components and liquid phase components, the specific components and their contents are shown in Table 1 below, wherein the solid phase components include polymethyl methacrylate (weight average molecular weight 650000), benzoyl peroxide, nano-hydroxyapatite modified by P(MMA-co-MPS), the liquid phase components include methyl methacrylate and N,N-dimethyl Based on the composition of p-toluidine, wherein the weight average molecular weight of P(MMA-co-MPS) is 59000, and the quality of hydroxyapatite modified by P(MMA-co-MPS) accounts for 50% of the total mass of solid phase components ; Mix the polymethyl methacrylate, benzoyl peroxide, methyl methacrylate and N,N-dimethyl-p-toluidine evenly, and then add the modified P(MMA-co-MPS) Nano-hydroxyapatite, which can be quickly cured and highly active component PMMA-based bone cement.

[0045] The preparation method ...

Embodiment 2

[0051] A kind of PMMA-based bone cement with high activity components that can be cured rapidly, including solid phase components and liquid phase components, specific components and their contents are shown in the following table 1, and the difference from Example 1 is that the P( The mass of hydroxyapatite modified by MMA-co-MPS was replaced by 45% of the total mass of the solid phase components. The preparation method of the above-mentioned high activity component PMMA-based bone cement is the same as that in Example 2.

Embodiment 3

[0053] A kind of PMMA-based bone cement with high active components that can be cured rapidly, including solid phase components and liquid phase components, specifically as shown in the following table 1, the difference from Example 1 is that the P(MMA-co-MPS) The weight average molecular weight is 55000. The preparation method of the above-mentioned high activity component PMMA-based bone cement is the same as that in Example 2.

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Abstract

The invention discloses a fast-curable high-activity component PMMA-based bone cement and a preparation method and application thereof. The rapidly-curable high-activity component PMMA-based bone cement of the present invention is The mass content of hydroxyapatite modified by co-MPS) and the weight average molecular weight of P(MMA-co-MPS) not only improve the biological activity of PMMA-based bone cement, but also enhance the mechanical properties of PMMA-based bone cement, The solidification process does not generate high heat, and the present invention further shortens the solidification time of bone cement by adding organic and inorganic two-phase solid powders separately. Accelerating the solidification can quickly relieve the pain of patients, meet clinical needs, and provide clinical guidance. sexual meaning.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a rapidly curable high-activity component PMMA-based bone cement and its preparation method and application. Background technique [0002] Polymethyl methacrylate (PMMA) bone cement is widely used in hip replacement and other surgeries because of its good biological and mechanical properties and rapid prototyping. But there are also the following disadvantages: first, a large amount of heat is released during the self-aggregation process, which can easily cause inflammation in the surrounding tissue, resulting in loosening between the implant material and the host bone; second, PMMA is an inert material and has no biological activity. Hydroxyapatite is a mineral component of human bone, and increasing the content of hydroxyapatite (HA) in bone cement helps to improve the bonding force between bone cement and autonomic bone. In view of the above shortcomings, Chinese pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/12A61L27/50A61L27/54
CPCA61L27/12A61L27/16A61L27/50A61L27/54A61L2430/02C08L33/12
Inventor 全昌云冯小瑜车有璐
Owner SUN YAT SEN UNIV
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