A preparation method of customizable, functional dressing

A functional, solution technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of easy increase of microorganisms and bacterial adhesion, hydrogels do not have waterproof and high strength, etc., to prevent wound infection and shorten the preparation time. , the effect of rich source of raw materials

Active Publication Date: 2021-11-16
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention is to solve the problem that hydrogel does not have waterproof and high strength, and the leakage of hydrogel dressing on the wound surface is easy to increase the adhesion of microorganisms and bacteria in the environment, and provides a preparation of a customizable and functional dressing method

Method used

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  • A preparation method of customizable, functional dressing
  • A preparation method of customizable, functional dressing
  • A preparation method of customizable, functional dressing

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specific Embodiment approach 1

[0033] Specific embodiment one: the preparation method of a kind of custom-made, functional dressing of this embodiment is specifically carried out according to the following steps:

[0034] 1. Preparation of polydimethylsiloxane / polyvinyl butyral / titanium dioxide nanocellulose film:

[0035] (1) TiO 2After blending nanoparticles with PDMS and ultrasonically dispersing them in tetrahydrofuran solution for 1-3 hours, put the mixture in a fume hood and let it stand for 18-48 hours to evaporate the tetrahydrofuran solution, and then use a light source intensity of 10mWcm while stirring -2 UV-A light irradiation for 8-12h dispersed TiO 2 nanoparticles, resulting in modified TiO 2 nanoparticles; then the modified TiO 2 The nanoparticles are centrifuged for 10 min under the condition that the rotating speed is 1000rpm; after the centrifugation, ultrasonic dispersion, standing, UV-A light irradiation and centrifugation are repeated 4-6 times to obtain a titanium dioxide suspension...

specific Embodiment approach 2

[0051] Specific embodiment two: the difference between this embodiment and specific embodiment one is: TiO in step one (1) 2 The mass ratio of nanoparticles to PDMS is 0.1:1-5, TiO 2 The volume ratio of the mass of nanoparticles to the tetrahydrofuran solution is 1g:5-50mL. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0052] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the mass fraction of PDMS in the PDMS / PVB solution described in step one (2) is 0.1-60%; TiO 2 The mass ratio of :PDMS is 0.1:2-5. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

A method for preparing a customizable, functional dressing. The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a customizable functional dressing. The present invention aims to solve the problem that the hydrogel is not waterproof and high-strength and that the hydrogel dressing is exposed to the surface of the wound and easily increases the adhesion of microorganisms and bacteria in the environment. Methods: (1) Preparation of PDMS / PVB / TiO by electrospinning technology 2 Nanocellulose membrane; (2) select plasma to treat nanofiber membrane; (3) use nanofiber membrane as carrier, 3D printing technology as means, use OTBC / GelMA / Laponite hydrogel as printing ink, according to actual needs Dressings are prepared to meet individual needs. It can be applied to the repair of various skin wounds such as chronic healing wounds (decubitus, diabetic foot), burns, scalds, etc., to meet the needs of patients and the nursing and treatment needs of medical staff.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a customizable functional dressing. Background technique [0002] As the largest organ in the human body, the skin can effectively prevent the loss of water, electrolytes and plasma proteins, resist the invasion of bacteria, prevent the entry of poisons, resist mechanical damage, prevent the damage of ultraviolet radiation to the human body, and maintain secretion, excretion and temperature regulation Therefore, the skin plays an important role in maintaining homeostasis and preventing microbial invasion. In particular, chronic and difficult-to-heal wounds on the body surface (diabetic chronic wounds) caused by population aging and other reasons have become an important factor that affects the harmonious development of society, reduces people's work and life quality, and increases the burden on society and families. In clinical ap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/18A61L15/24A61L15/26A61L15/40A61L15/44B33Y70/10
CPCA61L15/18A61L15/24A61L15/26A61L15/28A61L15/32A61L15/40A61L15/44A61L2300/102A61L2300/30A61L2300/404A61L2300/412A61L2400/12B33Y70/10C08L83/04C08L29/14C08L1/04C08L89/00
Inventor 栗洪彬郑永杰孙丹孟诗骐卜令鑫唐蓉蓉戴季良
Owner QIQIHAR UNIVERSITY
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