Dantrolene aqueous formulation and method for preparing same

Abstract

Provided as a technique for preparing an aqueous formulation of dantrolene or a pharmacologically acceptable salt thereof quickly and easily is a dantrolene aqueous formulation containing dantrolene or a pharmacologically acceptable salt thereof and a cyclodextrin derivative in which the amount of cyclodextrin derivative blended is from 0.5 mol to less than 2 mol per mol of dantrolene or pharmacologically acceptable salt thereof.

Description

technical field [0001] The invention relates to a dantrolene aqueous preparation and a preparation method thereof. Background technique [0002] Malignant hyperthermia, a complication of general anesthesia, is a serious complication with the highest mortality rate. Malignant hyperthermia develops in patients with genetic causes by general anesthesia using volatile inhalational anesthetics (halothane, etc.) or muscle relaxants (succinylcholine, etc.). The characteristic symptoms of malignant hyperthermia are muscle stiffness, tachycardia, and a sharp rise in body temperature. [0003] Dantrolene (Dantrolene) injection is the only treatment for malignant hyperthermia. Dantrolene is one of the muscle relaxants. It blocks the process of excitation from the transverse tubule to the sarcoplasmic reticulum by blocking the ryanodine receptor, thereby inhibiting the dissociation of calcium ions from the sarcoplasmic reticulum and causing muscle relaxation. [0004] Dantrolene inje...

AI Technical Summary

Problems solved by technology

However, since dantrolene is extremely poorly soluble in water, there is a problem that a large amount of solvent is required for dissolution and

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