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Lactic acid bacterium, agent for increasing blood iron, and agent for ameliorating anemia

A technology of lactic acid bacteria and additives, applied in the field of lactic acid bacteria, can solve problems such as unexpectable effects and difficulty in taking iron supplements

Pending Publication Date: 2021-05-25
ICHIBIKI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects of taking iron supplements sometimes mainly manifest as gastrointestinal symptoms such as abdominal pain, nausea, vomiting, diarrhea, and constipation. Therefore, it is difficult to take iron supplements.
In addition, when taking iron supplements, in order to increase the iron absorption effect, vitamin C is sometimes used together, but vitamin C is decomposed by gastric acid, so there is a problem that the effect cannot be expected unless a large amount of 1000 mg / time is taken.

Method used

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  • Lactic acid bacterium, agent for increasing blood iron, and agent for ameliorating anemia
  • Lactic acid bacterium, agent for increasing blood iron, and agent for ameliorating anemia
  • Lactic acid bacterium, agent for increasing blood iron, and agent for ameliorating anemia

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preparation example Construction

[0056] [3] The preparation method of lactic acid bacteria of the present invention:

[0057] The lactic acid bacteria of the present invention can be prepared by subjecting them to treatment such as sterilization after cultivation. Specifically, after the culture is completed, the culture medium components containing salt are removed by means such as centrifugation, and washed and purified. In addition, heat sterilization is performed, and then drying and concentration are performed by means such as freeze-drying, reduced-pressure drying, and hot-air drying. Thus, the lactic acid bacteria of the present invention can be produced.

[0058] It should be noted that heat sterilization is not particularly limited, and specifically, autoclave sterilization (121° C., 20 minutes) or equivalent sterilization is preferable.

[0059] [4] Ingestion time of lactic acid bacteria:

[0060] It is preferable to continuously ingest the lactic acid bacteria of this invention for 2 weeks or mo...

Embodiment 1

[0106] The iron concentration in serum (serum iron concentration) was measured before and after (day 14 and day 28) ingestion of lactic acid bacteria for 20 healthy Japanese people aged 20 to 45. It should be noted that serum iron concentrations were determined using a colorimetric method.

[0107] The ingestion method is: taking the lactic acid bacteria of the present invention (specifically, the lactic acid bacteria with the deposit number NITE BP-02318), namely the trade name "Zanghua Lactobacillus LTK-1" (manufactured by Ichiki Co., Ltd.) as a tablet of lactic acid bacteria (blood iron increaser, Anemia improving agent), 10 tablets a day (containing 1250mg of "Lactobacillus spp. LTK-1") orally ingested with water. The ingestion time was set to 28th. The results are shown in Table 1.

[0108] In addition, the safety of the ingestion based on the brand name "Lactobacillus Zanghua LTK-1" was also confirmed, and the adverse phenomenon considered to be a causal relationship w...

Embodiment 2

[0131] Nine healthy long-distance runners from corporate teams aged 22 to 27 were taken as subjects, before (2 months before, 4 months before, 6 months before) and after (2 months after, 4 months after) intake of lactic acid bacteria ) blood test. As described above, this blood test is performed once every two months.

[0132] Among the inspection items of the blood test, for hemoglobin, serum iron, and ferritin, the results before and after the ingestion of lactic acid bacteria are shown in Tables 3 to 6. In Tables 3 to 5, the "average value before the start of intake" represents each person who will perform blood tests three times before the intake of lactic acid bacteria (implemented 2 months before, 4 months before, and 6 months before the start of intake) The average value obtained by averaging. In addition, the "average value after ingestion start" shows the value which averaged the average value per person of 2 blood tests (implemented at the 2nd month and the 4th mon...

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Abstract

Provided is a lactic acid bacterium that is highly suitable for foods, can be easily produced and is capable of increasing the level of iron in the blood to thereby ameliorate anemia. A halotolerant lactic acid bacterium capable of increasing the level of iron in the blood.

Description

technical field [0001] The present invention relates to lactic acid bacteria, an agent for increasing iron in blood and an agent for improving anemia. More specifically, it relates to a lactic acid bacterium which has high food adaptability, is easy to manufacture, increases blood iron concentration, and improves anemia, an agent for increasing iron in blood, and an agent for improving anemia. Background technique [0002] According to the results of the National Health and Nutrition Survey in Japan in 2010, the average intake of most nutrients exceeds the estimated requirement, but the status quo is that the iron content (iron) of adult women (menstruation) has not changed and is still insufficient. [0003] If the insufficient iron content persists, the storage iron mainly composed of serum ferritin will decrease at first, and then the amount of hemoglobin and serum iron will decrease, leading to iron deficiency anemia. [0004] The state of reduced iron storage is called...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/744A61P7/00A61P7/06
CPCA61K35/744A61P7/00A61P7/06C12N1/205C12R2001/01A61K2035/115C12N1/20C12R2001/46A61K35/74
Inventor 西村笃寿浅井纪之熊泽利彦
Owner ICHIBIKI
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