A kind of precise temperature control device and method suitable for Ibuprofen Friedel-Crafts reaction

Abstract

The invention discloses a precision temperature control device and method suitable for the Friedel-Crafts reaction of ibuprofen. The device includes a tubular reaction heat exchanger and a temperature control system; the tubular reaction heat exchanger is sequentially arranged from the first end to the second end There are several reaction heat exchangers; each reaction heat exchanger is equipped with water inlet and water outlet; the temperature control system includes a cascade temperature control system and a process simulation predictive control module; the cascade temperature control system includes a temperature control loop, The refrigerated liquid flow control loop; the temperature control loop is the main loop, and the refrigerated liquid flow control loop is the secondary loop; the process simulation predictive control module is used to simulate the reaction process and generate compensation signals. The invention can effectively solve problems such as increased side reactions and reactor clogging caused by large fluctuations in reaction temperature, so that the selectivity of the target product is increased from about 83% to more than 95%, avoiding multiple shutdowns and cleaning of equipment, and improving production efficiency and stability.

Description

technical field [0001] The invention relates to the technical field of ibuprofen production process control, in particular to a precision temperature control device and method suitable for ibuprofen Friedel-Crafts reaction. Background technique [0002] Ibuprofen is a non-steroidal antipyretic analgesic with good therapeutic effect. Compared with general antipyretic analgesics, it has better effect and less side effects on people. It is widely used in colds, arthritis , anti-inflammatory and analgesic for muscle pain and other symptoms. Therefore it has wide applications in pharmaceutical production. The Friedel-Crafts reaction is the first step in the production of ibuprofen, and it is also a key step. It mainly generates ketone and gas from isobutylbenzene and chloropropionyl chloride under the catalysis of the catalyst aluminum trichloride, and contains excess chlorine Propylene chloride and aluminum trichloride. In this process, the temperature must be strictly contro...

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Problems solved by technology

[0004] The purpose of the present invention is to provide a precision temperature control device and method suitable for the Friedel-Crafts reaction of ibuprofen, to solve the technical problems in the prior art, and to reduce the temperature range of the Friedel-Crafts reaction from ±2°C to ±0.5°C. ℃, which solves the problems of increased side reactions and reactor clogging caused by large fluctuations in reaction temperature, which increases the selectivity of the target product from about 83% to more than 95%, avoids multiple shutdowns and cleaning of equipment, and improves production efficiency and stability

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