Sampling device

A sampling device and sample technology, applied in the medical field, can solve the problems of sampling device manufacturing cost, number of structural size parts and unfavorable working reliability, etc.

Pending Publication Date: 2021-06-11
BIOACES (SHANGHAI) LIFE SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This can be disadvantageous in terms of manufacturing cost, structural size, number of parts and operational reliability of the sampling device

Method used

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application example 1

[0031] Application example 1: Determination of infectious diseases in urine liquid samples.

[0032]The reagent insert of the sampling device may contain detection reagents for enzymatic verification of leukocytes, nitrite, albumin, occult blood and creatinine. In the case that there is a corresponding analyte in the liquid sample to be tested, a certain amount of the liquid sample to be tested is added to the injection port 1 with a pipette or a sampling needle, and the sample enters the sampling device and flows through the reagent embedding part 2 and the corresponding The reagent reaction then continues through the mixing section 4 to the detection zone 5 under the action of capillary force and fluid surface tension. The detection zone 5 can be entirely transparent, where the sample liquid can be analyzed visually and colorimetrically or by light techniques. And the content of the corresponding analyte in the sample liquid can be determined through the standard curve of t...

application example 2

[0033] Application example 2: Determination of glucose in serum.

[0034] The glucose content in serum can be determined by chemiluminescence. Glucose is oxidized enzymatically by glucose oxidase to gluconic acid with release of hydrogen peroxide. Luminol (3-aminobenzenedihydrazide) can be oxidized by an oxidant such as hydrogen peroxide in an alkaline medium to emit light with a wavelength of about 425nm. This reaction can be catalyzed by many metal ions. The intensity of chemiluminescence is directly proportional to the concentration of hydrogen peroxide produced (ie, to the concentration of glucose) and can be measured by commonly used photosensitive sensors. By measuring the luminous intensity of the glucose standard solution and the plasma sample and comparing them, the serum glucose content can be obtained.

[0035] In this application, a single reagent or multiple reagents are embedded in dry form in the embedding portion of the consumable. For example, glucose oxid...

application example 3

[0036] Application example 3: Determination of gonad-related detection items such as chorionic gonadotropin in serum (sandwich immunoassay). The sampling device can work similarly in this application.

[0037] The sampling device according to the invention can be used in cell biology experiments, such as cell counting and detection of cell viability.

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Abstract

The invention relates to a sampling device, which comprises a microfluidic flow channel, the microfluidic channel is provided with a sample inlet (1), a reagent embedding part (2), a mixing section (4), a detection area (5), a waste liquid section (6) and an exhaust hole (7), wherein the sample inlet (1) is used for inputting a biological fluid sample; the reagent embedding part (2) is arranged at the downstream of the sample inlet and contains a reagent for treating the biological fluid sample; the mixing section (4) is arranged at the downstream of the reagent embedding part; the detection area is arranged at the downstream of the mixing section, and the waste liquid section and the exhaust hole are arranged at the downstream of the detection area, the microfluidic flow channel is provided with a hydrophilic surface, and the microfluidic flow channel is configured to enable a biological fluid sample to flow to a detection area from a sample inlet through self-driving force formed by fluid surface tension and capillary force in the microfluidic flow channel. The sampling device can be manufactured with low cost, has few parts and works reliably.

Description

technical field [0001] The present disclosure relates to the field of medical technology, and more particularly, to a sampling device for biological fluid samples, especially a disposable consumable. Background technique [0002] Detection of biological fluid samples may be involved in life science research, biopharmaceuticals, medical diagnostics, and the like. Biological fluid samples can be, for example, human or animal blood, urine, body fluids, extracts of plants, which can be unpretreated or pretreated. For example, the number of red blood cells, the number of white blood cells, cell activity, etc. can be detected for a whole blood sample. The detection of biological fluid samples can involve, for example, applications in molecular diagnostics, immunofluorescence assays, and fluorescent antibody techniques. [0003] Publication US8906697B2 discloses a sampling device for evaluating liquid analytes, wherein the liquid sample to be tested is driven by a pump. This can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/14
CPCG01N1/14G01N2001/1472
Inventor 冯子寅
Owner BIOACES (SHANGHAI) LIFE SCI CO LTD
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