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Compositions having enhanced deposition of surfactant-soluble Anti-dandruff agents

A surfactant, composition technology, applied in the field of rinse-off personal care compositions, which can solve the problems of limited, expensive, time-consuming material evaluation scope, etc.

Pending Publication Date: 2021-06-18
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared to analytical measurements, in vitro or ex vivo tests, these in vivo tests are more expensive, time consuming and have limited scope for material evaluation

Method used

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  • Compositions having enhanced deposition of surfactant-soluble Anti-dandruff agents
  • Compositions having enhanced deposition of surfactant-soluble Anti-dandruff agents
  • Compositions having enhanced deposition of surfactant-soluble Anti-dandruff agents

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0286] Preparation of Deposition Control Cleaning Compositions

[0287] A deposition control composition was prepared by forming a formulation with the same surfactant soluble agent type, concentration, and surfactant concentration as the test composition in which the control formulation utilized sodium laureth-1 sulfate as the surfactant . The formulation was adjusted to about pH 6. For example, the formulation shown in Example 26 is a deposition control composition for the test composition shown in Example 25. The preparation techniques matched the protocols used to prepare the simple cleaning compositions tested.

[0288] Preparation of Example Cleaning Compositions

[0289] An exemplary cleaning composition is prepared by mixing the surfactant, surfactant soluble active, and remaining water with sufficient agitation to ensure a homogeneous mixture. The mixture may be heated to 50°C to 75°C to accelerate solubilization of the surfactant soluble agent and then cooled...

Embodiment 28-31

[0299] Discussion of Examples 28-31

[0300] In Examples 28-31, multiple levers were used to obtain high soluble agent concentration fractions: high soluble active content (C), low surfactant concentration (C s i ), and / or low intrinsic solubilizing power (K s i )). These high values ​​are also reflected in the high in vivo deposition results.

[0301] When all the data from Examples 17-31 are plotted as a set, a good correlation between fractional soluble agent concentration and deposition of surfactant soluble agent in vivo is evident ( figure 1 ).

[0302] figure 1 Fractional soluble agent concentration versus in vivo surfactant soluble agent deposition is shown for Examples 17-31.

[0303] The correlation between fractional soluble agent concentration and in vivo deposition of soluble agent is strong, and the determination of fractional soluble agent concentration is relatively readily available. Unlike in vivo deposition assays, the use of simple solutions prepa...

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Abstract

The present invention is directed to a hair care composition comprising from about 8% to about 25% of one or more surfactants, from about 0.01% to 10% of one or more surfactant-soluble agent; wherein the composition has a fractional soluble agent concentration (a) of 0.5-1.0, wherein 'a' is defined in the specification, C is the surfactant-soluble agent concentration, Cs are the surfactant concentrations and Ks is the solubilization capacity of each type of surfactant (e.g. in units of ppm octopirox / weight percent of surfactant), wherein Ks can be measured easily for any surfactant and surfactant-soluble agent combination.

Description

technical field [0001] The present invention relates to rinse-off personal care compositions in which it has surprisingly been found that deposition of surfactant soluble agents can be greatly enhanced by increasing the fractional soluble agent concentration. Background technique [0002] The condition of dandruff adversely affects a high percentage of people and there are numerous products that promise to alleviate the condition. While leave-on treatments were once common, many consumers prefer rinse-off treatment products, such as shampoos, for ease of application, time savings, and general convenience. An inherent problem with rinse-off treatments is that the wash event is quick and efficient, making it difficult to accomplish tasks other than cleaning during the process. Historically, this challenge has been met by creating shampoo formulations that use cationic polymers with anionic surfactants to form coacervates. These formulations are paired with particulate agents...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/46A61K8/49A61Q5/00
CPCA61Q5/006A61K8/34A61K8/4926A61K8/4946A61K8/463A61K8/466A61Q5/02
Inventor S·N·杰玛达尼L·E·布雷弗格雷D·L·库斯特E·S·约翰逊D·W·常
Owner PROCTER & GAMBLE CO