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7-dehydrocholesterol-hemimethanolate

A technology for dehydrocholesterol and methanolate, applied in the direction of steroids, organic chemistry, organic chemistry methods, etc., can solve problems such as prolongation

Pending Publication Date: 2021-06-22
DSM IP ASSETS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, 7-dehydrocholesterol has limited storage stability and degrades during prolonged storage

Method used

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  • 7-dehydrocholesterol-hemimethanolate
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Embodiment Construction

[0006] In a first aspect, the present invention relates to 7-dehydrocholesterol-hemimethanolate.

[0007] The ability of a substance to exist in more than one crystalline form is often referred to as polymorphism, and these different crystalline forms are often called "polymorphs" and can be detected by certain analytical properties (such as their X-ray powder Diffraction (X-ray powder diffraction, XRD) pattern) for reference. In general, polymorphism reflects the ability of a molecule to change its conformation or form different inter- and intra-molecular interactions. This can lead to different atomic arrangements, which are reflected in the crystal lattices of the different polymorphs. However, polymorphism is not a universal feature of solids, as some molecules are able to exist in one or more crystalline forms, while others cannot. Thus, the presence or extent of polymorphisms for a given compound is unpredictable.

[0008] Different polymorphic forms of a substance ex...

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Abstract

The present invention relates to 7-dehydrocholesterol-hemimethanolate. It has been found that the formation of 7-dehydrocholesterol-hemimethanolate offers an efficient method of increasing the storage stability of 7-dehydrocholesterol, respectively of decreasing the degradation upon storage of 7-dehydrocholesterol.

Description

technical field [0001] The present invention relates to the field of 7-dehydrocholesterol. Background technique [0002] 7-Dehydrocholesterol is a key intermediate used in the synthesis of cholecalciferol (=vitamin D3). [0003] However, 7-dehydrocholesterol has limited storage stability and degrades during prolonged storage. Contents of the invention [0004] Therefore, the problem to be solved by the present invention is to increase the storage stability of 7-dehydrocholesterol, or to reduce the degradation of 7-dehydrocholesterol during storage. Surprisingly, it has been found that 7-dehydrocholesterol-hemimethanol exhibits polymorphism. 7-Dehydrocholesterol-hemicarbinolate offers a solution to this problem. 7-Dehydrocholesterol-hemimethanol can be readily formed from 7-dehydrocholesterol. Furthermore, 7-dehydrocholesterol can be easily regenerated in high yield from 7-dehydrocholesterol-hemimethanolate. It has been found that 7-dehydrocholesterol-hemimethanol exhi...

Claims

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Application Information

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IPC IPC(8): C07J9/00
CPCC07B2200/13C07J9/00
Inventor 马丁·贡纳·伊格兰毛鲁斯·马蒂
Owner DSM IP ASSETS BV
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