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Skin aging protein marker-APOA2 protein and non-invasive extraction method thereof

A skin aging, skin technology, applied in the field of molecular biology

Pending Publication Date: 2021-06-25
杨森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no precedent for using apolipoprotein A-II (APOA2) to assist in judging the degree of skin aging

Method used

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  • Skin aging protein marker-APOA2 protein and non-invasive extraction method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment

[0083] Using a relatively close living environment and healthy people as samples, skin samples from the curved side of the forearm were collected non-invasively (using 3M adhesive skin for sampling).

[0084] The present invention is to the measuring method of different protein content in experimenter's skin sample, according to the following steps:

[0085] (1) HPLC

[0086] Obtaining samples: 3M medical adhesive tape was pasted on the curved side of the forearm to exclude photoaging factors. (3M medical adhesive tape is 2.4cm, manufacturer: 3M Health Care 3M Brookings.), after 1 minute, gently peel off the 3M adhesive tape to ensure that the subject's skin is not damaged, and obtain a tape-like skin sample;

[0087] (1) Cut the tape-like skin sample into small pieces (0.5 x 0.5 cm) with a sterile razor blade and deposit on a glass plate before transferring to a 1.5 ml centrifuge tube; (2) Add appropriate amount of lysis buffer sample without SDS , add 2mM EDTA, 1XCocktail,...

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Abstract

The invention provides a skin aging protein marker-APOA2 protein and a non-invasive extraction method of the skin aging protein marker-APOA2 protein. The method aims at finding internal factors causing skin aging from the source, intervening the skin aging in advance before the skin aging appears; in addition, the protein is capable of correctly judging the aging degree of the skin and judging whether the physiological age of the aging conforms to the actual age or not, and providing reference and direction for beauty or medical beauty.

Description

technical field [0001] The invention belongs to the field of molecular biology, and in particular relates to a skin aging protein marker-APOA2 protein and a non-invasive extraction method thereof. Background technique [0002] Skin aging is divided into extrinsic aging and endogenous aging. Extrinsic aging mainly refers to aging caused by environmental factors such as ultraviolet radiation, smoking, wind, sun exposure and exposure to harmful chemicals; Aging is also called "chronological aging", which is mainly determined by genes. Skin aging generally begins at the age of 30 and becomes more apparent with age. The aging speed has obvious individual differences and is affected by the combined effects of internal and external environmental factors. Correctly judging the aging degree of the skin and judging whether the biological age of aging is consistent with the actual age are the prerequisites for cosmetology or medical cosmetology. [0003] APOA2: It has a high protein ...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N1/28G01N1/34G01N30/02G01N30/06G01N30/72G16B20/00
CPCG01N1/28G01N1/286G01N1/34G01N30/02G01N30/06G01N30/72G01N33/6881G01N2333/47G01N2800/7042G16B20/00
Inventor 杨森张学军张博
Owner 杨森
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