324 results about "Ageing skin" patented technology

The invention discloses a collagen composition for skin substrate repair and skin care application thereof, and the collagen composition comprises the following components: 1-3% of soluble III-type collagen, 1-5% of hyaluronic acid, 1-2% of plant extract, 0.1-0.5% of allantoin, 0.2-0.5% of dipotassium glycyrrhizinate, 1-5% of glycerol, 1-5% of butanediol, 1-5% of 1, 2-propylene glycol, 1-5% of 1, 3-propylene glycol, 1-5% of propylene glycol and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 1 to 2 percent of 1, 2-hexanediol, 0.1 to 0.5 percent of phenoxyethanol, 0.1 to 0.5 percent of ethylhexylglycerin, 0.1 to 0.5 percent of carbomer, 0.1 to 0.5 percent of triethanolamine and the balance of water. The collagen III is added, so that the problems of wrinkles and skin aging are remarkably relieved. According to the skin-care lotion, the oily composition and the water-based composition are reasonably proportioned, so that excellent moistening and moisturizing effects are provided, the moisture balance of the skin is favorably maintained, and the skin is kept soft and moist. The added plant extract, hydrolyzed protein and mineral substances not only nourish and repair the skin, but also can improve various skin problems, enhance the endurance capacity of the skin and avoid the condition that the skin wrinkles are increased during the period of stopping using.

The invention belongs to the technical field of cosmetics, and particularly relates to a camellia-seed oil composition with anti-oxidation and whitening effects and application of the camellia-seed oil composition. The camellia seed oil composition comprises the following components in parts by weight: 1-8 parts of camellia seed oil, 0.5-5 parts of hydrolyzed royal jelly protein and 1-5 parts of fermented cynara plantaginis seed oil. According to the composition, the camellia seed oil, the hydrolyzed royal jelly protein and the fermented plantain herb seed oil are organically combined, and the composition with the anti-oxidation and whitening effects is researched and developed. Experiments and exploration find that the three components are matched with one another in a preferable dosage range of the whitening composition, an ideal synergistic effect can be achieved, free radicals can be effectively resisted, skin aging can be delayed, uneven skin color can be remarkably improved, color spots can be remarkably lightened, and a good whitening effect can be achieved.

A biosynthesis method for preparing royal jelly acid and the use thereof in skin care, which belong to the technical field of genetic engineering and biosynthesis. The royal jelly acid is produced by means of fermentation on the basis of yeast engineering bacteria using a culture medium containing trans-2-decenoic acid. An assessment at both skin cell level and skin model level shows that royal jelly acid can promote the synthesis of stratum corneum lipids and ceramide on aging skin and repair the skin barrier; and also can promote the synthesis of mitochondria ATP and NADPH in skin fibroblasts, reduce the active oxygen content of mitochondria, improve mitochondrial dysfunctions, and inhibit apoptosis. Further experiments show that royal jelly acid can repair DNA damage of fibroblasts caused by ultraviolet irradiation, reduce telomere shortening caused by cell division and replication, and strengthen the protection of chromosomal terminal regions. The prepared royal jelly acid has wide application prospects in the development of functional skin care products for skin repairing, aging resisting, etc.

The invention relates to the technical field of daily chemicals, in particular to a dark tea extract containing eurotium cristatum composite strains for solid aerobic fermentation. The composite strains comprise eurotium cristatum and saccharomycetes. The dark tea extract provided by the invention is stable in performance and not easy to discolor, contains components such as polysaccharide, amino acid and mineral substances, and can help skin moisturize. The permeability of the components is enhanced in the fermentation process, moisture can be locked on the surface layer of the skin, and the moisture degree of the skin is kept. The skin care product has very strong antioxidant capacity, and can neutralize free radicals, slow down the oxidation process of skin, delay skin aging and reduce wrinkles and fine wrinkles. A certain calming effect can be achieved on the skin which is prone to redness and itching or has slight inflammation.

The present invention relates to the field of biomaterials, specifically a collagen material comprising recombinant humanized collagen type 21 (ColpepA1 21) and its application in facial augmentation. This invention utilizes collagen to not only provide an effective solution to skin aging but also promotes the natural synthesis of collagen within the skin, optimizing skin hydration and barrier function, and enhancing the skin's self-repair capacity. The resulting collagen material is a facial augmentation material. Through local injection or external application, it rapidly smoothes and firms the facial skin, while also improving overall skin health with long-term use.

The invention discloses application of plant-derived extracellular vesicles in preparation of a product for preventing and treating photoaging and a topical application composition. Pseudo-ginseng is used as a raw material for extraction and purification of plant-derived extracellular vesicles, and results show that the pseudo-ginseng-derived extracellular vesicles can significantly treat or improve photoaging. The invention explores the practical application of the fresh pseudo-ginseng extracellular vesicles based on the traditional theory of traditional Chinese medicine, and clarifies the molecular mechanism of the pseudo-ginseng extracellular vesicles. In a word, the extracellular vesicles derived from pseudo-ginseng have a wide application prospect in treatment of skin aging.

The present invention relates to a functional cosmetic composition comprising plant exosomes derived from ginseng as an active ingredient and a functional cosmetic containing the same. Ginseng exosomes have a bilipid layer structure and are rich in ginsenosides Rb1 and Rg1, which influence skin improvement and whitening. It has been proven that these powerful functional materials, ginsenosides Rb1 and Rg1, are absorbed in large quantities through ginseng exosomes into skin cells, enhance the synthesis of collagen and hyaluronic acid in skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosomes rich in ginsenosides Rb1 and Rg1, presented in the present invention, can be beneficially used in functional cosmetic compositions for skin aging prevention, skin whitening, wrinkle improvement and skin cell regeneration.

The invention relates to a composite gel for treating skin aging by using PLLA, CMC and hyaluronic acid. The composite gel is prepared from the following raw materials: 300 to 310 mg of PLLA microspheres for injection, 50 mg of CMC, 35 to 40 mg of hyaluronic acid and 5 to 8 ml of normal saline. The invention also relates to a preparation method of the composite gel for treating skin aging by using PLLA, CMC and hyaluronic acid. The PLLA microspheres and the hyaluronic acid are combined for use, respective advantages can be exerted, and the PLLA microspheres can provide lasting stimulation and promote an organism to continuously generate collagen; and hyaluronic acid can immediately improve the moisture degree and plumpness of the skin. The combination of the collagen and the collagen has the effects of integrating multiple effects, enhancing aging resistance and improving skin quality, and fundamentally solves the problem of skin aging caused by loss of collagen.

The present invention relates to a functional cosmetic composition comprising plant exosome derived from ginseng as an active ingredient thereof and a functional cosmetic comprising the same. Ginseng efflux has a dual lipid layer structure and is rich in ginsenosides Rb1 and Rg1 that affect skin improvement and whitening. The powerful functional substances ginsenosides Rb1 and Rg1 have been proved to be massively absorbed into skin cells through ginseng exosomes, enhance the synthesis of collagen and hyaluronic acid in the skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosome rich in ginsenosides Rb1 and Rg1, as presented in the present invention, can be advantageously used in a functional cosmetic composition for skin aging prevention, skin whitening, wrinkle reduction, and skin cell regeneration.

The present invention relates to a compound for inducing the expression of the anti-aging gene klotho and a preparation method therefor. The compound represented by Chemical Formula 1, according to the present invention, has an excellent effect of increasing the expression level of the klotho gene which is a gene associated with aging, and thus can be useful for a pharmaceutical composition, cosmetic composition or food composition for preventing skin aging, inhibiting cellular senescence or preventing, treating alleviating a vascular aging-induced disease or a renal disease.

The invention belongs to the technical field of active polypeptides and preparation, and particularly relates to an antioxidant and anti-inflammatory cyclopeptide capable of inhibiting matrix metalloproteinase as well as a preparation method and application of the antioxidant and anti-inflammatory cyclopeptide. The cyclic peptide is formed by end-to-end covalent coupling of linear peptide with the amino acid sequence of DEETGEF, has the activity of resisting oxidation, resisting inflammation and inhibiting matrix metalloproteinase, is free of cytotoxicity and skin irritation, and is suitable for being used as cosmetics for resisting skin aging, wrinkles and the like.

The invention relates to a composition with anti-inflammatory and anti-aging effects and application thereof, the composition comprises a dogwood extract, a radix fici simplicissimae extract and a guava extract, the composition can effectively scavenge free radicals, inhibit collagenase activity and inhibit generation of fluorescent AGEs, and the composition has the anti-inflammatory and anti-aging effects. Skin aging and skin laxity and darkness caused by glycosylation reaction are prevented. Meanwhile, by inhibiting NO secretion, the composition relieves skin inflammation reaction and can also improve skin microcirculation. All the components have a synergistic effect, so that the anti-oxidation, anti-inflammatory, anti-aging and anti-saccharification effects are remarkably enhanced, and the skin problems are comprehensively solved. No organic solvent is used in the process, the green and environment-friendly concept is met, the safety and reliability of the extract are ensured, and a mild and efficient solution is provided for anti-aging.

The invention relates to the technical field of skin care products, in particular to a multi-cell extract, a preparation method and application of the multi-cell extract in anti-aging skin care products. The multi-cell extract comprises a leukocyte extract and at least one plant cell extract, the plant cell extract is derived from any one or a mixture of more of MALUS DOMESTICA fruit cell culture extract and ADENIUM OBESUM leaf cell extract, each component of the multi-cell extract is derived from natural plants and leukocytes, and each component of the multi-cell extract is derived from natural plants and leukocytes. The traditional Chinese medicine composition is safe and reliable, small in irritation to skin, simple in component composition, lower in cost and low in sensitization, and has a good market prospect.

The invention relates to an anti-aging composition containing recombinant collagen and a preparation method thereof. The main component of the composition is high-purity collagen obtained through a gene recombination technology, and various anti-aging active components such as sodium hyaluronate, vitamin C, coenzyme Q10 and vitamin E are combined. The invention also provides a preparation method, which ensures that each component is uniformly distributed and the biological activity is not damaged through low-temperature homogenization treatment and accurate proportioning. The composition disclosed by the invention can be used for remarkably promoting the proliferation of human skin fibroblasts and enhancing the expression of I-type collagen genes, and has a remarkable anti-aging effect. The composition is high in safety and remarkable in effect, is suitable for preventing and treating skin aging, and is widely applied to the fields of medicines and cosmetics.

The invention discloses a polypeptide with anti-aging and anti-inflammatory activity and application thereof, and belongs to the field of biological medicine. In the prior art, anti-aging components are large in side effect, single in action target, unreasonable in polypeptide substance sequence design, insufficient in stability and difficult to give consideration to anti-aging and anti-inflammatory synergistic effects. The sequence provided by the invention comprises a polypeptide as shown in SEQ ID No.1 and a polypeptide with the homology not lower than 85%, and the polypeptide can be prepared into cosmetics or health care products. The polypeptide provided by the invention can promote collagen synthesis, inhibit inflammatory factors, improve skin aging and inflammation, and also can improve bone quality.

The invention relates to a micromolecule RNA (Ribonucleic Acid) composition and an application thereof in preparing a skin beautifying and repairing product. Comprising tiRNA-1: 34-Glu-CTC-1-M2 and tRF-1: 30-Glu-CTC-1-M2, and the nucleotide sequences of the tiRNA-1: 34-Glu-CTC-1-M2 and the tRF-1: 30-Glu-CTC-1-M2 are as shown in SEQ ID The invention further provides application of the small molecule RNA composition in preparation of skin beautifying and repairing products. It is found for the first time that the composition of tiRNA-1: 34-Glu-CTC-1-M2 and tRF-1: 30-Glu-CTC-1-M2 can promote proliferation and migration of human skin cells, collagen synthesis and secretion in the human skin cells and expression of genes related to angiogenesis are improved, and meanwhile aging of the human skin cells is delayed. Besides, the small molecule nucleic acid RNA composition reduces expression of inflammation-related factors so as to exert an anti-inflammatory effect, exerts the effects of promoting skin regeneration and repair, improving skin aging, resisting inflammation, promoting skin collagen and blood vessel regeneration and the like, can be used for preparing skin beautifying and repairing products, provides a new method and a new thought for the field of skin beauty treatment, and has wide application prospects. Good commercial application prospects are realized.

This invention relates to the use of a bacterium of the species Ligilactobacillus salivarius, Lacticaseibacillus paracasei, Lacticaseibacillus rhamnosus, Lactiplantibacillus plantarum or a mixture thereof, for preventing, reducing or treating skin aging in a subject.

The invention provides a composition for improving the permeation effect of a Campania maculata bark extract as well as a preparation method and application of the composition, and relates to the technical field of cosmetics. The invention provides an anti-aging composition for improving the permeation effect of a Campandra maculata bark extract. The anti-aging composition comprises recombinant human III type collagen, the Campandra maculata bark extract, an annona squamosa fruit extract, a Flos Magnoliae extract and a film-forming agent, the film-forming agent is composed of rhamnose and a trimethyl pentanediol / adipic acid / glycerol cross-linked polymer. The combination of the recombinant human III type collagen and the film-forming agent can strengthen hydration of cuticle, optimize the controlled release efficiency of active ingredients and broaden the permeation path, thereby forming an efficient permeation network from the skin surface to the deep layer. The combination of the Campandra mollissima bark extract, the Annona mollissima fruit extract and the Flos Magnoliae extract can construct a multi-dimensional antioxidant network, activate longevity proteins to resist saccharification and DNA damage, and comprehensively delay skin aging.

An anti-aging injection composition, an anti-aging injection, and use thereof. The anti-aging injection composition contains hyaluronic acid or a salt thereof, glycine, proline, lysine hydrochloride, and leucine, which can synergistically promote the generation of collagen and elastin in the skin, thereby helping to correct skin wrinkles, improve skin elasticity, and enhance skin radiance. The anti-aging injection composition can be used to prepare an anti-aging injection, which has the effect of resisting skin aging.

One or more techniques and / or systems are disclosed for formulating a skin care product to mitigate aging or to restore damaged skin. One skin care product includes a blend of growth factors, peptides, and amino acids. Also disclosed is a skin care product formed from a synthesized protein matrix. The synthesized protein matrix can mimic the regenerative effects of human placental proteins, which are desirable when applied to skin because, as skin loses its regenerative properties, humans shows signs of aging, and a decrease in healing capabilities. The exemplary skin-care products disclosed herein can be applied to skin to help mitigate this skin aging process or to restore damaged skin.

The invention relates to the field of skin care products, and provides a compound anti-aging skin-firming polypeptide skin care product and a preparation method thereof. The skin care product is prepared from a plurality of active ingredients such as acetyl octapeptide-3 loaded nanoparticles, a copper peptide nano lipid complex, palmitoyl pentapeptide-4, sodium hyaluronate, glycerol and squalane. The acetyl octapeptide-3 loaded nanoparticles are obtained by loading acetyl octapeptide-3 on glutamine-based nanoparticles prepared by an emulsion polymerization method; the copper peptide nano-lipid complex is prepared by combining an emulsification method with a high-pressure homogenization technology, so that the stability and the transdermal absorption performance of the polypeptide are remarkably improved. The preparation method comprises the following steps: preparing a water phase, an oil phase and a polypeptide active solution, emulsifying, uniformly mixing and carrying out vacuum defoaming to finally form a stable emulsion finished product. The skin care product disclosed by the invention has multiple effects of resisting aging, tightening skin, deeply moisturizing, resisting oxidation and the like, solves the technical problems of long-term sustained release and aging resistance of polypeptide, and has wide application value.

The present invention relates to the field of cosmetic technology, and specifically discloses a composite vegetable oil and a preparation method thereof. A composite vegetable oil comprises sunflower seed oil, olive oil, jojoba seed oil, palm fruit oil and sea buckthorn seed oil. The present application produces a significant synergistic effect in regulating skin oil secretion by rationally matching five kinds of vegetable oils, namely sunflower seed oil, olive oil, jojoba seed oil, palm fruit oil and sea buckthorn seed oil. Such a composite vegetable oil can not only repair abnormal skin oil secretion and maintain the water-oil balance of the skin, but also deeply moisturize the skin, solve the problem of skin dehydration, repair the damaged skin barrier, and reduce the damage of the external environment to the skin. In addition, the composite vegetable oil also has the effects of anti-oxidation and anti-aging, can effectively delay skin aging, and keep the skin young.

The present disclosure provides esters of a retinoid and bakuchiol, such as esters of Formula (I′). The present disclosure also provides compositions and kits comprising the esters, methods of producing the esters, methods of using the esters (e.g., for treating or preventing a skin disease, slowing the ageing of the skin, improving the appearance of the skin, or modulating a retinoid receptor).

The invention belongs to the technical field of cosmetics, and discloses a preparation process of a composition with an anti-wrinkle effect and application of the composition in cosmetics, the composition comprises a mixing tank, and the top of the mixing tank is provided with a tank cover; the discharging pipe is connected to the bottom of the mixing tank; the first driving part is connected to the top of the tank cover, the output end of the first driving part is connected with a rotating shaft, and a first cleaning assembly is arranged in the bottom end of the rotating shaft; the stirring rod is connected to the outer side of the rotating shaft, and stirring assemblies are arranged on the outer side of the stirring rod and the bottom of the rotating shaft. Through natural plant extracts and bioactive components, skin barriers are repaired while deep moisturizing and skin color brightening are achieved, the problem of dry skin is solved, the elasticity and compactness of the skin are improved, fine lines and wrinkles are reduced, skin aging is delayed, the antioxidant capacity is high, and compared with other anti-wrinkle products, chemical additives harmful to the skin are not contained; and the formula is low in cost and suitable for large-scale production.

A skin care composition includes a plurality of agents that include at least one retinol derivative that may comprise, for example, hydroxypinacolone retinoate, and at least one bark extract that may comprise, for example, Eperua falcata bark extract, the plurality of agents providing reduced retinol associated inflammation as compared with a composition that includes the at least one retinol and lacks the at least one bark extract. The plurality of agents may also include hydroxy acid, for example, comprising lactic acid. The composition may confer one or a combination of increased skin cell proliferation, improved cellular migration, improved cellular differentiation, an anti-inflammatory retinol genetic signature as demonstrated by via bulk-RNA sequencing of human keratinocytes and restores epidermal disruption and reduce IL-1A and IL-23 inflammatory cytokines in human ex-vivo skin models of chronic inflammation.

The invention provides nanoscale ginseng, a preparation method and application thereof and a cosmetic, and relates to the technical field of cosmetics. The preparation method provided by the invention comprises the following steps: carrying out infiltration, microwave radiation pretreatment and dissolution on ginseng to obtain a nano spray drying preparation solution; the nano-scale ginseng is prepared by using a nano spray drying technology. The invention further provides application of the nanoscale ginseng in preparation of cosmetics with anti-inflammatory, anti-oxidation and anti-aging effects. The nanoscale ginseng disclosed by the invention is natural in component, mild and safe, can effectively improve the transdermal absorption of human skin, improve the skin chromaticity and reduce the melanin content of the skin, and can effectively solve the problems of wrinkles and reduced elasticity caused by skin aging. In addition, the preparation method is simple and convenient, and large-scale production and application are facilitated.

The invention relates to a cosmetic composition, advantageously an ecobiological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by general formula (I), in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an α-amino acid selected from the group consisting of: tryptophan, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The invention also relates to the use of the cosmetic composition for combatting skin redness and / or skin ageing; to the use thereof for preventing and / or combatting cutaneous hypervascularisation and / or skin inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combatting these conditions.

A skin care composition includes a plurality of agents that include at least one retinol derivative and at least one bark extract, the plurality of agents providing reduced retinol associated inflammation as compared with a composition that includes the at least one retinol and lacks the at least one bark extract. The plurality of agents may include at least one retinol derivative comprising hydroxypinacolone retinoate and at least one bark extract which may include at least one bark extract comprising Eperua falcata bark extract. The plurality of agents may also include at least one hydroxy acid, for example, comprising lactic acid. The composition confers one or more of increased skin cell proliferation, improved cellular migration, improved cellular differentiation, or a combination thereof. Application the plurality of agents confers to skin cells and tissues an anti-inflammatory retinol genetic signature as demonstrated by via bulk-RNA sequencing of human keratinocytes and restores epidermal disruption and reduce IL-1A and IL-23 inflammatory cytokines in human ex-vivo skin models of chronic inflammation.

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

The present invention relates to a cosmetic composition comprising galactomyces, having skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving properties, and more specifically, comprises a galatomyces fermentation filtrate, a rice lees distillate, sh-oligopeptide-1, a plant extract, a skin conditioning agent, a pH regulator, a surfactant, an emollient, a sequestering agent, a film-forming agent, and a thickener. The cosmetic composition comprising said ingredients is less likely to cause skin irritation by having a large amount of natural ingredients, is eco-friendly by upcycling rice lees, exhibits skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving effects by containing an abundant amount of galactomyces, vitamins, minerals, and organic acid ingredients, and improves skin health by preventing skin aging and skin damage and promoting skin cell regeneration.