109 results about "Ageing skin" patented technology

The invention discloses application of plant-derived extracellular vesicles in preparation of a product for preventing and treating photoaging and a topical application composition. Pseudo-ginseng is used as a raw material for extraction and purification of plant-derived extracellular vesicles, and results show that the pseudo-ginseng-derived extracellular vesicles can significantly treat or improve photoaging. The invention explores the practical application of the fresh pseudo-ginseng extracellular vesicles based on the traditional theory of traditional Chinese medicine, and clarifies the molecular mechanism of the pseudo-ginseng extracellular vesicles. In a word, the extracellular vesicles derived from pseudo-ginseng have a wide application prospect in treatment of skin aging.

The present invention relates to a functional cosmetic composition comprising plant exosomes derived from ginseng as an active ingredient and a functional cosmetic containing the same. Ginseng exosomes have a bilipid layer structure and are rich in ginsenosides Rb1 and Rg1, which influence skin improvement and whitening. It has been proven that these powerful functional materials, ginsenosides Rb1 and Rg1, are absorbed in large quantities through ginseng exosomes into skin cells, enhance the synthesis of collagen and hyaluronic acid in skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosomes rich in ginsenosides Rb1 and Rg1, presented in the present invention, can be beneficially used in functional cosmetic compositions for skin aging prevention, skin whitening, wrinkle improvement and skin cell regeneration.

The present invention relates to a compound for inducing the expression of the anti-aging gene klotho and a preparation method therefor. The compound represented by Chemical Formula 1, according to the present invention, has an excellent effect of increasing the expression level of the klotho gene which is a gene associated with aging, and thus can be useful for a pharmaceutical composition, cosmetic composition or food composition for preventing skin aging, inhibiting cellular senescence or preventing, treating alleviating a vascular aging-induced disease or a renal disease.

The invention discloses a polypeptide with anti-aging and anti-inflammatory activity and application thereof, and belongs to the field of biological medicine. In the prior art, anti-aging components are large in side effect, single in action target, unreasonable in polypeptide substance sequence design, insufficient in stability and difficult to give consideration to anti-aging and anti-inflammatory synergistic effects. The sequence provided by the invention comprises a polypeptide as shown in SEQ ID No.1 and a polypeptide with the homology not lower than 85%, and the polypeptide can be prepared into cosmetics or health care products. The polypeptide provided by the invention can promote collagen synthesis, inhibit inflammatory factors, improve skin aging and inflammation, and also can improve bone quality.

The invention provides a composition for improving the permeation effect of a Campania maculata bark extract as well as a preparation method and application of the composition, and relates to the technical field of cosmetics. The invention provides an anti-aging composition for improving the permeation effect of a Campandra maculata bark extract. The anti-aging composition comprises recombinant human III type collagen, the Campandra maculata bark extract, an annona squamosa fruit extract, a Flos Magnoliae extract and a film-forming agent, the film-forming agent is composed of rhamnose and a trimethyl pentanediol / adipic acid / glycerol cross-linked polymer. The combination of the recombinant human III type collagen and the film-forming agent can strengthen hydration of cuticle, optimize the controlled release efficiency of active ingredients and broaden the permeation path, thereby forming an efficient permeation network from the skin surface to the deep layer. The combination of the Campandra mollissima bark extract, the Annona mollissima fruit extract and the Flos Magnoliae extract can construct a multi-dimensional antioxidant network, activate longevity proteins to resist saccharification and DNA damage, and comprehensively delay skin aging.

One or more techniques and / or systems are disclosed for formulating a skin care product to mitigate aging or to restore damaged skin. One skin care product includes a blend of growth factors, peptides, and amino acids. Also disclosed is a skin care product formed from a synthesized protein matrix. The synthesized protein matrix can mimic the regenerative effects of human placental proteins, which are desirable when applied to skin because, as skin loses its regenerative properties, humans shows signs of aging, and a decrease in healing capabilities. The exemplary skin-care products disclosed herein can be applied to skin to help mitigate this skin aging process or to restore damaged skin.

The invention belongs to the technical field of cosmetics, and discloses a preparation process of a composition with an anti-wrinkle effect and application of the composition in cosmetics, the composition comprises a mixing tank, and the top of the mixing tank is provided with a tank cover; the discharging pipe is connected to the bottom of the mixing tank; the first driving part is connected to the top of the tank cover, the output end of the first driving part is connected with a rotating shaft, and a first cleaning assembly is arranged in the bottom end of the rotating shaft; the stirring rod is connected to the outer side of the rotating shaft, and stirring assemblies are arranged on the outer side of the stirring rod and the bottom of the rotating shaft. Through natural plant extracts and bioactive components, skin barriers are repaired while deep moisturizing and skin color brightening are achieved, the problem of dry skin is solved, the elasticity and compactness of the skin are improved, fine lines and wrinkles are reduced, skin aging is delayed, the antioxidant capacity is high, and compared with other anti-wrinkle products, chemical additives harmful to the skin are not contained; and the formula is low in cost and suitable for large-scale production.

A skin care composition includes a plurality of agents that include at least one retinol derivative that may comprise, for example, hydroxypinacolone retinoate, and at least one bark extract that may comprise, for example, Eperua falcata bark extract, the plurality of agents providing reduced retinol associated inflammation as compared with a composition that includes the at least one retinol and lacks the at least one bark extract. The plurality of agents may also include hydroxy acid, for example, comprising lactic acid. The composition may confer one or a combination of increased skin cell proliferation, improved cellular migration, improved cellular differentiation, an anti-inflammatory retinol genetic signature as demonstrated by via bulk-RNA sequencing of human keratinocytes and restores epidermal disruption and reduce IL-1A and IL-23 inflammatory cytokines in human ex-vivo skin models of chronic inflammation.

A skin care composition includes a plurality of agents that include at least one retinol derivative and at least one bark extract, the plurality of agents providing reduced retinol associated inflammation as compared with a composition that includes the at least one retinol and lacks the at least one bark extract. The plurality of agents may include at least one retinol derivative comprising hydroxypinacolone retinoate and at least one bark extract which may include at least one bark extract comprising Eperua falcata bark extract. The plurality of agents may also include at least one hydroxy acid, for example, comprising lactic acid. The composition confers one or more of increased skin cell proliferation, improved cellular migration, improved cellular differentiation, or a combination thereof. Application the plurality of agents confers to skin cells and tissues an anti-inflammatory retinol genetic signature as demonstrated by via bulk-RNA sequencing of human keratinocytes and restores epidermal disruption and reduce IL-1A and IL-23 inflammatory cytokines in human ex-vivo skin models of chronic inflammation.

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

The present invention relates to a cosmetic composition comprising galactomyces, having skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving properties, and more specifically, comprises a galatomyces fermentation filtrate, a rice lees distillate, sh-oligopeptide-1, a plant extract, a skin conditioning agent, a pH regulator, a surfactant, an emollient, a sequestering agent, a film-forming agent, and a thickener. The cosmetic composition comprising said ingredients is less likely to cause skin irritation by having a large amount of natural ingredients, is eco-friendly by upcycling rice lees, exhibits skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving effects by containing an abundant amount of galactomyces, vitamins, minerals, and organic acid ingredients, and improves skin health by preventing skin aging and skin damage and promoting skin cell regeneration.

The application discloses application of plant-derived extracellular vesicles in preparation of products for preventing and treating photoaging and a local application composition. The application takes Panax notoginseng as raw material to extract and purify the plant-derived extracellular vesicles, and the results show that the extracellular vesicles derived from Panax notoginseng can significantly treat or improve photoaging. The application explores the practical application of extracellular vesicles of fresh Panax notoginseng based on traditional Chinese medicine theory, and clarifies the molecular mechanism of the extracellular vesicles. In general, the extracellular vesicles derived from Panax notoginseng have wide application prospects in treatment of skin aging.

The present disclosure relates to a novel peptide and a composition for alleviating skin aging, a composition for caring for skin damage or alleviating skin sagging, a composition for reversing aging, an anti-glycation composition, a composition for preventing hair loss or promoting hair growth, and a composition for improving skin barrier function, wherein the compositions comprise the novel peptide.

Several examples presented relate to a cosmetic formulation containing less than approximately 0.6% by weight of gelling agent, but which maintains a minimum viscosity of at least 2000 cPs and is stable for up to four weeks after manufacture. The present invention relates to a formulation having a gelling agent comprising both a polyacrylate and xanthan gum, an emulsifier capable of forming a water-in-oil formulation, one or more skin-conditioning agents configured to treat a user's skin, and one or more solvents.

The present invention relates to a cosmetic or pharmaceutical composition comprising a physiologically acceptable medium and an active ingredient capable of increasing the expression of a mitochondrial-derived peptide, more particularly a cerebrasin, where the active ingredient may be a peptide, a plant extract, a plant extract, or a plant extract. The present invention relates to an aqueous extract of an aqueous extract, such as an aqueous extract of a fruit pulp of phoenix dactylifera, an aqueous extract of a seed of germinated red clover, an aqueous extract of a seed of Chenopodium quinoa, or an aqueous extract of a root of Iris pallida, for example, an aqueous extract of a fruit pulp of phoenix dactylifera, an aqueous extract of a seed of germinated red clover, an aqueous extract of a seed of Chenopodium quinoa, or an aqueous extract of a root of Iris pallida. The invention also relates to a cosmetic treatment method for protecting the skin and accessories from external infringement and against skin aging.

The invention relates to the technical field of skin care, and discloses a composition for improving skin aging and a preparation method and application thereof. The feed additive is prepared from the following raw materials in parts by mass: 18 to 30 parts of yeast extract, 18 to 30 parts of rhizoma curcumae longae extract, 12 to 25 parts of mixed herbal extract, 12 to 25 parts of linear aspartame extract, 5 to 15 parts of green tea extract, 0 to 4 parts of vitamin B3, 0 to 3 parts of vitamin B5, 0 to 2 parts of vitamin B7, 0 to 2 parts of vitamin B12, 0 to 1 part of vitamin B6, 0 to 1 part of vitamin B1, 0 to 1 part of vitamin B2 and 0 to 1 part of folic acid. The preparation method of the capsule preparation comprises the following steps: taking the raw materials according to the mass parts of the composition, and uniformly mixing to obtain an intermediate product; controlling the mass content of water in the intermediate product to be less than or equal to 5.0% And filling the intermediate product into a plant-based capsule shell. Human body trial feeding verifies that the composition can effectively improve skin cell metabolism, relieve inflammatory response, clear ROS and AGEs, inhibit melanogenesis, promote skin hydration and delay skin photoaging.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and to methods for promoting healthy skin aging, treating skin disorders, treating cardiovascular disorders, treating renal disorders, treating angiogenesis disorders, such as cancer, treating tissue damage, such as non-cardiac tissue damage, treating progressive myocardial infarction, and treating various other disorders, such as complications resulting from diabetes with the compounds and compositions of the invention. Other disorders may include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, skin infections, peripheral vascular disease, stroke, and the like.

The present invention relates to a dermatological and cosmetic composition comprising a mixture of amino acids, hyaluronic acid or salts thereof and tricarboxylic acid cycle acids, in particular malic acid and succinic acid or salts thereof. The composition according to the present invention can be used to resist skin aging caused by decreased extracellular matrix deposition.

The present invention pertains to a cosmetic composition, quasi-drug composition and pharmaceutical composition containing graphene quantum dots as an active ingredient, and provides a composition that prevents skin aging by providing a skin regenerating, anti-wrinkle, moisturizing or antioxidant effect.

The invention relates to the technical field of skin care products, and discloses a composition with oil-controlling, soothing and acne-removing effects and a preparation method and application thereof.The composition with the oil-controlling, soothing and acne-removing effects contains active ingredients including quaternary ammonium salt-73, a white willow bark extract and a centella asiatica extract, the obtained composition has the effects of dredging pores, resisting bacteria, controlling oil and relieving, can effectively reduce the number of blackheads and acnes, prevent acne formation and relieve acne red and swollen, can repair damaged barriers, enhance skin resistance, fade acne marks and delay skin aging, and is suitable for nursing acne skin, oily skin and sensitive skin.

The present invention is related to a skin care composition comprising (1) a physiologically acceptable medium and (2) a synergistic composition consisting of: a blend of a Nelumbo nucifera (Sacred Lotus) serum fraction and a Camellia sinensis (Tea) serum fraction in a respective weight ratio of 75:25; or a blend of a Nelumbo nucifera (Sacred Lotus) serum fraction and a Chamomilla recutita (German chamomile) serum fraction in a respective weight ratio of 75:25. The invention also relates to a method for improving skin appearance associated with skin aging comprising applying compositions thereof.

The invention relates to an mRNA (messenger Ribonucleic Acid) molecule and application thereof in preparation of beauty and skin care products, and particularly, the mRNA molecule comprises a nucleic acid sequence for coding type III collagen. After the mRNA provided by the invention is applied to the skin, the skin cells can generate collagen, and the aged skin is normalized by increasing the collagen content in the skin tissue, so that the effect of repairing the skin is achieved.

The invention relates to a platinum compound-containing transdermal absorption type composition for delaying skin aging as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The invention provides a transdermal absorption type composition containing a platinum compound, which can obviously improve the skin permeability of the olive leaf extract, so that active substances can more easily penetrate through the cuticle and the corium layer to play a role, and the active ingredients are ensured to be absorbed and utilized by the skin to the maximum extent. Furthermore, the active ingredients in the transdermal absorption type composition are scientifically proportioned, the skin resistance is improved through antioxidation and anti-inflammation, a regeneration environment is created through moisturizing and barrier repair, and finally, structural rejuvenation is realized through collagen stimulation, so that a defense-repair-regeneration multi-dimensional synergistic network is formed, and the skin regeneration effect is improved. The effects of promoting permeation of functional components, moisturizing, repairing, tightening, resisting aging and delaying skin aging are doubly improved.

The application belongs to the technical field of skin care products, and discloses a kind of repair anti-aging skin care composition and preparation method thereof;The composition comprises ceramide complex, polyphenol supramolecular complex, polyol humectant, emollient oil, oil-soluble emulsifier, water-soluble thickener, ectoine, preservative, chelating agent and pH regulator;The ceramide complex is compounded by ceramide NP, ceramide AP, ceramide EOP, phytosphingosine and cholesterols according to molar ratio, and the polyphenol supramolecular complex is ternary inclusion nanocomposite formed by oligomeric procyanidins, hydroxypropyl-beta-cyclodextrin and ceramide NP through supramolecular self-assembly;The composition has barrier repair and anti-aging dual effects, and solves the problem that ceramide repair components and polyphenol anti-aging components are difficult to be stable in the same formula system.

The invention discloses application of R-1, 3-butanediol in preparation of anti-aging cosmetics or medicines, and relates to the technical field of cosmetics. According to the embodiment of the invention, the R-1, 3-butanediol is applied to the skin, and the R-1, 3-butanediol is explored and proved to be capable of exceeding the traditional physical and chemical functions of R-1, 3-butanediol, being utilized by cells, participating in the energy metabolism process of the skin cells, regulating the energy metabolism of mitochondria and regulating the expression of AMPK protein in the skin cells; the skin function is improved from the fundamental level of cell energy supply, and the skin aging problem caused by cell metabolism decline is resisted. The positioning and action mechanism is different from all known traditional applications, and represents a brand-new application mode of the component in cosmetics based on cytobiology. The functional skin care product is expected to be promoted to be upgraded to the direction of cellular metabolism regulation, and is popularized and applied.

The utility model relates to a beauty instrument, which comprises a main shell; the solution bottle is fixed in the main shell, and the main shell is provided with a liquid outlet driving device matched with the solution bottle; the liquid outlet ball is rotatably arranged at the liquid outlet of the solution bottle, a plurality of microchips are fixed on the liquid outlet ball, and a microneedle array is arranged on any microchip. According to the utility model, the rollable liquid outlet ball is arranged, so that the absorption of essence can be accelerated, the absorption effect is improved, when the liquid outlet ball is in contact with the skin, the pressure is more uniform and softer, the skin cannot be damaged or stimulated by dermis, and compared with a product in the prior art, the liquid outlet ball is safer, milder and capable of moving in any direction; the use comfort of a user can be improved, and meanwhile the effects of delaying skin aging, improving wrinkles and the like can be better achieved.

Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.

The present application belongs to the field of cosmetics, and provides a long-acting mild anti-wrinkle supramolecular polypeptide composition, a preparation method and application thereof. The composition comprises a botulinum-like polypeptide with anti-wrinkle effect, a polypeptide with the effect of promoting the growth of skin cell collagen, a polypeptide with the effects of soothing, anti-allergy and anti-inflammation, and a supramolecular ionic liquid with the effect of penetration promotion. The long-acting mild anti-wrinkle supramolecular composition provided by the present application is centered on the three targets of anti-skin aging: smoothing fine lines, tightening skin and resisting inflammation, and at the same time, the soothing and anti-allergy effects which are not possessed by traditional anti-wrinkle skin care products are taken into account, so as to fully meet the needs of consumers with different skin conditions; on the basis of self-assembly of polypeptides into supramolecular structures, the stable compounding of 10 kinds of functional polypeptides is completed through a reasonable preparation method and proportion, and the problem of poor compatibility of functional components is solved; on the basis of the supramolecular structure, the supramolecular ionic liquid is combined for further penetration and delivery, and the synergistic effect also effectively protects the inner supramolecular polypeptide structure.

The invention is generally directed to active ingredients capable of countering dermal intrinsic ageing and its manifestations, compositions containing them and their use as cosmetic or medical (e.g. dermatological) dermal compositions. The agents inhibit or reduce the biosynthesis of secreted frizzled-related protein 4 (SFRP 4) and reduce expression of p21 in fibroblasts.

The invention belongs to the technical field of cosmetics, and particularly relates to a plant extract composition with anti-aging and soothing effects and a preparation method thereof. The composition is prepared from the following components in parts by mass: 1 to 5 parts of herba portulacae extract, 0.5 to 3 parts of chamomile extract, 0.1 to 1 part of cedar oil, 0.1 to 1 part of sandalwood oil, 2 to 10 parts of boa oil, 0.5 to 3 parts of lavender extract, 0.5 to 2.5 parts of gomphrena globosa extract, 0.3 to 2 parts of magnolia flower extract and 0.5 to 4 parts of rose extract. The composition disclosed by the invention can not only relieve the problem of skin sensitivity from the source, but also effectively delay the skin aging process through a multi-target synergistic mechanism such as oxidation resistance, inflammation resistance, barrier repair, moisturizing, microcirculation promotion and the like, and realizes the dual effects of resisting aging and relieving through a multi-channel synergistic effect.