364 results about "Ageing skin" patented technology

This invention relates to in-situ preparation of the derivatives of various hydroxy acids (HA), such as alpha-(Alpha) Hydroxy Acids (AHA), beta-(Beta) Hydroxy Acids (BHA), and Poly-Hydroxy Acids (PHA) with certain skin beneficial organic hetero-atom bases and their application in skin resurfacing (exfoliation), and in the synergistic treatment and regulation of topical disorders of skin such as skin aging, wrinkles, acne, rosacea, age-spots, canker sores, striae distensae (stretch marks), pimples, skin redness, and dry skin conditions of cracking, flaking, and scaling. Most HA derivatives produced by the in-situ method do not cause skin irritation and skin redness effects that are commonly experienced with AHA and BHA, yet there is no loss of their skin beneficial effects. These compositions can be traditional water and oil emulsions, liposomes, suspensions, colloids, solutions, masks, muds, serums, sprays, gels, lotions, creams, cleansers, and anhydrous systems, thus offering a wide choice of formulations to meet their consumer appeal and acceptance requirements.

The present invention relates to the use of one or more tripeptides selected from the group consisting of NLys-Pro-ValC, NLys-Pro-ThrC and NpGLu-His-ProC for the reduction of oxidative stress. The above tripeptides are particularly useful for the treatment of a disease or damage caused by oxidative stress; such as vitiligo, scleroderma, necrosis, or erythema; furthermore, a disease or damage of the hair, like premature hair loss or premature formation of grey hair. Furthermore the invention relates the cosmetic use of the above tripeptides, in particular against skin aging. Further the invention relates cosmetic compositions containing at least one of said tripeptides.

The present invention refers to surgery threads which are flexible, made of resistant inert plastic material and being employed in aesthetic surgeries in the cases of skin ageing prevention and / or correction surgeries for motion injury signals, wherein the threads comprise a previous defined sequence of a tissue support arrangement having a number of fixing claws placed alongside of the thread surface and wherein an arrangement of an upstream claw (1) set and a downstream claw (2) set is provided.

The present invention relates to methods and compositions comprising naphthoquinones such as 2,3-dimethylnaphthalene-1,4-dione, for the use of treating, regulating or preventing a skin condition characterized by oxidative stress or a degenerative process. Methods of preventing, lightening or reducing the appearance of visible and / or tactile discontinuities of the skin resulting from skin pigmentation or skin aging are also disclosed.

The invention discloses an external skin care product capable of adjusting skin immunity and delaying skin aging. The external skin care product is characterized by comprising powder, an aqueous solution and emulsion, wherein the powder comprises oligopeptide-1 and ginsenoside; the aqueous solution comprises glycyrrhiza glabra root extract, artemisia capillaris flower extract, mulberry root extract, jujube fruit extract, scutellaria root extract, hydrolyzed rice protein and nicotinamide; and the emulsion comprises hgytantriol bifida ferment lysate, creatine, carnosine, alpha glucosyl hesperidin, hexapeptide-3, centella asiatica extract, coenzyme Q10 inclusion complex, opuntia ficus-indica stem extract, rhodiola rosea extract, saussurea involucrate extract, pseudo-ginseng root extract and Chinese angelica extract inclusion complex. According to the external skin care product, the powder, the aqueous solution and the emulsion are jointly used, and the external skin care product can reduce wrinkle and pachulosis, even skin tone and improve skin elasticity and skin firmness, so that the skin is finer and smoother and looks young.

I have discovered that trace metals such as copper, zinc, iron, and manganese that are necessary for the proper functioning of superoxide dismutase (SOD) and other deactivators of active-oxygen molecules (which cause aging of skin and other skin disorders), can be delivered from the topical compositions. This is achieved by the preparation of copper and other trace metal complexes with phosphorylated nucleosides, such as nucleotides, and phosphorylated monosaccharides, such as phosphorylated glycosides which act as small molecular weight (SMW) transporter molecules. These trace metal complexes of nucleotides and glycosides can be prepared by an in-situ method in water, water-miscible organic solvent, or a mixture of water and water-miscible organic solvent from commonly available ingredients in concentrations that are desirable and can be accurately controlled. I have additionally discovered compositions to achieve the transport of copper from the surface layers of skin into the deeper layers of skin utilizing SMW transporter molecules; and the intra-cellular storage of copper ions in the cell, for example in a bound form with glutathione; and the intra-cellular transport of copper from glutathione to SOD apoprotein by metallochaperones; and the supply of energetic molecules, such as ATP, ADP, or phosphorylated saccharides for SOD metallochaperones to perform their intra-cellular metal transfer function. These cosmetic or pharmaceutical compositions are useful for antiaging and antiviral benefits.

The present invention relates to a method for stimulating collagen synthesis and / or KGF expression, and more particularly, to a method for stimulating collagen synthesis and / or KGF expression using the AIMP1 or its fragment. The AIMP1 or its fragment can be effectively used for the stimulation of collagen synthesis and / or KGF expression in a subject in need thereof, the treatment of skin aging in the subject, the treatment of the flaccid and / or wrinkled skin in the subject, the promoting the smoothing and / or firming of the skin in the subject, the treatment of adverse cutaneous effects of menopause in the subject, and the treatment of adverse effects of menopause on the collagen.

The invention discloses a multi-effect skin caring and smoothening traditional Chinese medicine lotion which is characterized by comprising, by weight, 35-45 parts of lightyellow sophora root, 35-45 parts of common cnidium fruit, 28-33 parts of Chinese gall, 35-45 parts of baical skullcap root, 18-22 parts of cattail pollen, 75-85 parts of ganoderma lucidum, 110-130 parts of cortex mori, 35-45 parts of milkvetch root, 35-45 parts of radix rehmanniae, 35-45 parts of oat, and glycerin which is 0.5-0.56 times of the aforementioned materials by weight, with the balance being clean water for extraction. The multi-effect skin caring and smoothening traditional Chinese medicine lotion made from natural and environment-friendly materials has stable and reliable effect and wide application range, especially has good effects in removing freckle, wrinkle and acne, whitening, moisturizing and healing skin injury, and can not only be used to delay aging of skin and repair injury to skin caused by some hormone drugs and cosmetics but also reduce and even remove face splash, acne and wrinkle to make skin smooth, bright and elastic.

The invention discloses a Prinsepia utilis Royle oil-containing functional skin care product and a preparation method thereof. The Prinsepia utilis Royle oil-containing functional skin care product is prepared from the following raw materials in part by weight: 1 to 2 parts of Prinsepia utilis Royle oil, 10 to 25 parts of purslane extracting solution, 5 parts of glycerol, 2 to 3 parts of 1,2-pentanediol, 5 to 7 parts of caprylic / caprictriglycerides, 2 parts of synthetic squalane, 1 to 5 parts of tocopheryl acetate, 1 to 3 parts of cetearyl alcohol, 0.1 to 0.2 part of allantoin, 0.6 to 0.9 part of coconut oil-base glucoside, 0.5 to 1 part of coconut oil alcohol, 0.5 to 2 parts of glyceryl stearate, 0.1 to 1 part of sodium hyaluronate and the balance of water. The functional skin care product has mild property and high safety without toxic or side reaction and anaphylactic reaction, can repair the destructed skin barrier, resists inflammation and skin ageing, and has a good effect and high safety of assisting in treating skin diseases related with skin barrier destruction, such as facial dermatitis (hormone dependence dermatitis, allergic dermatitis and acne), atopic dermatitis and the like.

The invention belongs to the field of cosmetics, and particularly relates to a composition containing bifida ferment lysate and a preparation method and application of the composition to the cosmetics. The composition includes a bifida ferment lysate composition, a peptide composition and a rice extract, and the composition is prepared from the following components in parts by mass: 1-40 parts ofthe bifida ferment lysate, 1-20 parts of the peptide composition, and 1-20 parts of the rice extract, and the composition further includes 1-20 parts of a moisturizing composition, and the bifida ferment lysate composition includes bifida freeze-dried powder, and a bifida freeze-dried powder lyase solution. The composition containing the bifida ferment lysate has the beneficial effects that a formula is reasonably set, functions are various, wrinkles can be significantly reduced, the pigment content is reduced, skin glossiness is increased, the skin color is brightened, skin elasticity is increased, the skin barrier is repaired, the water loss is reduced, the composition has no stimulation to the skin, and at the same time, the composition has the functions of preventing skin aging and keeping moisture for a long time, and makes the skin obtain a healthy and natural bright white state.

The invention belongs to the technical field of skin care oil medicine, in particular to skin care oil medicine containing peony oil and a preparation method thereof. The skin care oil medicine provided by the invention comprises the following components in parts by weight: main ingredients: peony seed oil, caprylic / capric triglyceride, cyclopentasiloxane and 1, 2 - butyl glycol 1-12, wherein the peony oil is peony seed oil or peony essence oil or the mixture of peony seed oil and peony essence oil; auxiliary ingredients: isostearic acid, butylated hydroxytoluene, avocado oil, simmondsia chinensis seed oil, meadowfoam seed oil and macadamia ternifolia seed oil; the skin care oil medicine containing peony oil prepared by the method provided by the invention can remarkably improve of the skin epidermis cell cycle function, promote the microcirculation of the blood capillary of the dermal skin effect, inhibit lipid peroxidation, improve metabolism, delay skin aging process, is provided with anti-wrinkle, moisturizing and whiting effect, people feels smooth and comfortable after the skin care oil medicine is used on the skin, and the skin care oil medicine containing peony oil is provided with better effect to chloasma, aging skin wrinkles, skin cutin hardening peeling and skin chap.

The invention belongs to the technical field of cosmetics and particularly relates to a spray agent containing wormwood hydrolat and a preparation method thereof. The spray agent containing wormwood hydrolat is mainly prepared from the wormwood hydrolat, rose hydrolat, chamomile extract, trehalose, allantoin, dipotassium glycyrrhizinate, hyaluronic acid, glycerinum, preservative and water. The spray agent containing the wormwood hydrolat has the functions of sterilization property, antianaphylaxis and antiphlogosis and itching relieving of broad spectrum and meanwhile has the effects of slowing down skin aging, promoting blood circulation of skin, supplementing water, moisturizing, refreshing and restoring consciousness. The spray agent containing wormwood hydrolat is free of stimulation to skin, the phenomenon of skin poisoning can be avoided after the spray agent is used for a long time, and the spray agent is suitable for being used for various people, especially suitable for being used by people with sensitive skin.

The present invention relates to extract of Cercis chinensis having anti-oxidant activity and antiaging activity containing compound of chemical formula 1 to chemical formula 20, and cosmetical composition for anti-oxidation, skin-aging protection and wrinkle improvement containing the extract as effective ingredient. The extract of present invention having protective effect on oxidative damage and skin damage, and inhibitory effect on age-dependent telomere shortening, so it can effectively used as skin-aging protection comestic.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and / or intracellular proteins and / or their genes in skin cells and / or skin tissues, wherein the secretory proteins and / or intracellular proteins change their expression with aging of skin. The present invention also provides a kit for determining the degree of skin aging and a method for identifying substances effective in the prevention of skin aging.

The invention discloses an Rg2 group and an Rh1 group of red ginseng saponin and a preparation method as well as applications in preparing cosmetics preventing skin aging. Extracts which are extracted from ginseng roots, do not contain saponin, and contain saponin enzyme of ginseng and other water-soluble matters react with ginsenoside Re to obtain red ginseng mixed saponin Rg2 group consisting of red ginseng rare saponin 20(S)-Rg2, 20(R)-Rg2, Rg4 and Rg6, and the extracts react with ginsenoside Rg1 to obtain the red ginseng mixed saponin Rh1 group consisting of red ginseng rare saponin 20(S)-Rh1, 20(R)-Rh1, Rh4 and Rk3. Compared with a saponin Rg2 monomer and a saponin Rh1 monomer, the function of the Rg2 group and Rh1 group of red ginseng mixed saponin for promoting skin fibroblast collagen synthesis is improved obviously, the Rg2 group and Rh1 group of red ginseng mixed saponin are more safe to skin and human bodies, and have less side effects.

Compounds of structural formula (I) are disclosed as useful for modulating the androgen receptor (AR) in a tissue selective manner in a patient in need of such modulation, and in particular for antagonizing AR in the prostate of a male patient or in the uterus of a female patient and agonizing AR in bone and / or muscle tissue. These compounds are useful in the treating conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, female sexual dysfunction, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, prostate cancer, arthritis and joint repair, alone or in combination with other active agents. In addition, these compounds are useful as pharmaceutical composition ingredients alone and in combination with other active agents.

Compositions are provided that include date palm pollen or an extract thereof. The compositions may be formulated for topical use in methods of treatment or prophylaxis of various skin conditions or methods to counteract the effects of skin aging.

The present invention provides a skin external-use agentia combination which contains more than one of a lotus extract and a dark plum extract serving as effective components and has an antioxidant activity. The skin external-use agentia combination of the present invention has an excellent antioxidant effect, and can be applied to cosmetic material combinations or pharmic combinations. In addition, the skin external-use agentia combination of the present invention also can effectively prevent erythema, improve colour of the skin, and prevent skin from aging.

The invention belongs to the technical field of cosmetics and particularly discloses a skin care matrix with moisture preserving and oxidation resisting effects. The skin care matrix is prepared from the following components in parts by weight: 25-30 parts of apple fruit extracts, 20-25 parts of sodium carboxymethyl glucan, 2-3 parts of oligomeric sodium hyaluronate, 6-10 parts of water-soluble fullerene, 15-20 parts of colloidal platinum and 12-32 parts of water. By rational combination of effective substances and optimization of the dosage of the substances, the four active effective substances are complementary, can be degraded and completely absorbed by skin, provide nutrients for the skin and have long-lasting moisture preserving and oxidation resisting effects. The prepared skin care matrix can be added to cream, milk lotions, lotions and other cosmetics and can improve the moisture preserving and oxidation resisting effects of the cosmetics, so that the skin is moisturized and whippy, and aging of the skin is prevented.

The invention discloses a compound with a wrinkle removing function. The compound comprises triterpenoid saponin and triterpene acid, wherein the triterpenoid saponin and the triterpene acid are active ingredients from centella. The triterpenoid saponin comprises one or two of asiaticoside and hydroxy asiaticoside, and the triterpene acid comprises one or two of asiatic acid and madasiatic acid. By compounding any one or two of the triterpenoid saponin with any one or two of the triterpene acid, human skin fibroblast secretes type I collagen, and the like can be remarkably improved, the obvious effect of aging skin regeneration is realized, and the compound can be used for the development of wrinkle removing cosmetics.

The invention provides an anti-aging compound, an anti-aging cosmetic and a preparation method thereof. According to the anti-aging compound, plantain herb seed extract, lupine extract and lotus extract are compounded, so that skin aging can be effectively prevented and improved, skins can be tightened, and a skin anti-aging function is achieved. Besides, according to the anti-aging cosmetic, the anti-aging compound serves as an active component, other raw materials serve as auxiliary materials to prepare anti-aging skin lotion, anti-aging emulsion and anti-aging cream, so that use requirements of different people in different places can be met while skin aging can be effectively resisted. According to the method, the components serve as raw materials, the raw materials are mixed and emulsified to prepare corresponding anti-aging cosmetics, and the preparation method has the advantages of convenience, fine effect of the prepared anti-aging cosmetic and the like.

The invention relates to a composition containing umbilical cord mesenchymal stem cell exosomes. The composition comprises the following components in percentage by mass: 0.02-0.6% of the umbilical cord mesenchymal stem cell exosomes, 2.5-5.0% of an antioxidant, 1.5-2.5% of algal polysaccharides, 5.6-12.5% of a humectant, 0.05-0.6% of nicotinamide, 0.2-0.8% of hydroxyethyl cellulose, 0.1-0.5% of ceramide-2,, and the balance of deionized water. According to the composition, on the basis of adding the umbilical cord mesenchymal stem cell exosomes, the humectant, the antioxidant and the algal polysaccharides are matched, so that metabolism of skin cells can be accelerated, oxidation resistance and regeneration capacity of basal cells can be recovered, skin aging can be prevented, skin elasticity and plumpness can be increased, pores can be shrunk, and gloss can be improved.

The invention specifically relates to a cosmetic preparation prepared from human umbilical cord mesenchymal stem cell-derived exosomes, belonging to the field of biological medicine. The cosmetic preparation comprises freeze-dried powder of human umbilical cord mesenchymal stem cell-derived exosomes, glycerin and aloe juice in a weight ratio of 1: 1: 10-20. A preparation method for the cosmetic preparation comprises the following steps: weighing the human umbilical cord mesenchymal stem cell-derived exosomes, glycerin and aloe juice in proportion, then carrying out mixing under stirring until a transparent mixture is obtained, and subjecting the mixture to filtering with a 0.45-[mu]m microfiltration membrane and then to filtering with a 0.22-[mu]m microfiltration membrane so as to obtain the cosmetic preparation. According to the invention, the novel human umbilical cord mesenchymal stem cell-derived exosomes are used as an active component for preparation of the cosmetic preparation with obvious effect; and the cosmetic preparation can overcome the problem of skin aging of people and has good market prospects and application value.

Disclosed is a cosmetic or dermatological preparation which comprises one or more extracts of Saxifraga oppositifolia (purple saxifrage) and / or one or more extracts of Soldanella alpina (alpine snowbell). The use of these extracts to combat extrinsic and intrinsic skin aging is likewise described.

The invention discloses a traditional Chinese medicine composition for beautifying skin. The effective components of the composition consists of the following raw medicines in daily dosage: 2 to 8 grams of ginseng, 3 to 6 grams of angelica, 3 to 9 grams of red sage roots, 100 to 700 milligrams of forest frog oviducts and 145 to 900 milligrams of grape seed extract. The medicine composition can be added with microcrystalline cellulose or magnesium stearate as auxiliary materials to prepare tablets, or be added with stearic acid, glyceryl monostearate, hydrogenerated polyisobutene, olive oil, methyl glucose sesquistearate, glycerin, azone, ethyl nipagin ester and distilled water as the auxiliary materials to prepare cream. The composition has the advantages of high product safety performance, no toxic or side effect, speckle removal, wrinkling resistance, skin aging improvement, good skin beautifying efficacies, and stable and reliable product quality. In addition, the composition is rich in resources of the raw medicines, scientific and reasonable in formulation and simple in preparation process, and meets the requirements of industrial production.

The invention relates to a cosmetic and / or pharmaceutical composition comprising, in a physiologically suitable medium, a carob peptide extract (Ceratonia siliqua L.) as an active agent for promoting aquaporin expression. The present invention also relates to the use of a carob peptide extract (Ceratonia siliqua L.), as an active agent for promoting aquaporin expression, in a cosmetic composition for improving the moisturization and the barrier function of the epidermis and for stimulating skin regeneration. The invention also relates to the use of this novel active agent for preparing a pharmaceutical, in particular dermatological, composition for regulating and / or stimulating aquaporin activity. The invention also relates to a cosmetic treatment method for preventing or combating dryness of the skin and mucous membranes and the manifestations of skin aging.

Signs of aging of the skin and / or mucous membranes are prevented and / or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic / pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.

The invention specifically discloses a composite anti-ageing skin-care composition and a manufacturing method. The composite anti-ageing skin-care composition comprises the following raw materials by weight: 0.05 to 10 parts of traditional Chinese medicine active site extract, 0.05 to 5 parts of polypeptide composition, 0.02 to 3 parts of diguanosine tetraphosphate and 82 to 99.88 parts of deionized water. The traditional Chinese medicine active site extract comprises the following raw materials by weight: 10 to 40 parts of lanatechead saussurea herb with flower, 2 to 30 parts of Chinese angelica, 5 to 25 parts of tuber of dwarf lilyturf and 5 to 30 parts of honeysuckle flower; and the polypeptide composition is a composition of two or more selected from the group consisting of tripeptide, tetrapeptide, pentapeptide, hexapeptide and nonapeptide. Since a plurality of traditional Chinese medicinal active components are added into anti-ageing active matters of the composite anti-ageing skin-care composition, the composite anti-ageing skin-care composition is capable of nourishing and moisturizing the skin, rectifying qi and blood, nourishing yin, moisturizing dryness, clearing away heat and toxic matters, highly efficiently removing oxyradical, inhibiting activity of tyrosinase and controlling melanin generation, has powerful anti-ageing, skin-care and skin-tenderizing effects and is free of toxicity and harm. When added into a cosmetic, the composition exerts substantial anti-ageing effect.