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Method for preparing at least one generator with high radium-228 content

A generator and a single technology, applied in chemical instruments and methods, separation methods, radium compounds, etc., can solve the problems of frequent replacement of generators, low content of thorium-228, etc.

Pending Publication Date: 2021-06-29
オラノメッド
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This aspect leads to the fact that the subsequent elution of the generator in order to obtain thorium-228 results in an eluate not only with a lower content of usable thorium-228, but also in which the thorium-228 is diluted to a greater extent, and On the other hand leads to more frequent replacement of the generator

Method used

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  • Method for preparing at least one generator with high radium-228 content
  • Method for preparing at least one generator with high radium-228 content
  • Method for preparing at least one generator with high radium-228 content

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no. 1 approach

[0122] In this first embodiment, the method is aimed at producing a single generator.

[0123] The method first comprises performing n times the following sequence of steps a) to d) by means of a single first chromatographic column 10 containing a stationary phase 20:

[0124] a) circulating an aqueous solution A1 comprising thorium-232, radium-228 and nitric acid through the column 10 as long as the retention of radium-228 by the stationary phase 20 is at least equal to a threshold value;

[0125] b) washing the stationary phase 20 with an aqueous solution A2 comprising nitric acid to remove from the stationary phase 20 the thorium-232 present in the interstitial volume of the stationary phase when the retention of radium-228 is below a threshold value;

[0126] c) Radium-228 is eluted from the stationary phase 20 with aqueous solution A3 containing EDTA as complexing agent, and will contain 228 The eluate or aqueous solution A4 of radium-228 in the form of Ra-EDTA complex i...

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Abstract

The invention relates to a method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

Description

technical field [0001] The present invention relates to the field of production of radioactive isotopes (also known as radioisotopes). [0002] More specifically, the present invention relates to a method of preparing one or more generators having a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. [0003] This generator or generators are particularly useful in the production of thorium-228 from which radium-224, and then lead-212 and bismuth-212 can be obtained. [0004] Therefore, the method and the generator produced by the method can be especially applied to the preparation of lead-212 or bismuth-212-based radiopharmaceuticals, which are suitable for nuclear medicine, especially for targeted alpha radiotherapy for cancer treatment. Background technique [0005] Targeted alpha radiation therapy, also known as targeted alpha therapy, involves the injection of a radioactive isotope bound to a carrier, such as an antibody, that targets...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/04C01F15/00G21G4/08G21G1/00
CPCG21G4/08G21G1/0005B01D15/1871
Inventor J·托格雷米·迪罗
Owner オラノメッド