Application of GSDMD as biomarker in differential diagnosis and curative effect evaluation of pleural effusion related diseases

A biomarker, pleural effusion technology, applied in the field of differential diagnosis and curative effect evaluation of pleural effusion-related diseases, can solve the problems of low diagnostic sensitivity and poor specificity of tuberculous pleurisy, and achieve the effect of good clinical application value

Active Publication Date: 2021-07-13
李朴 +1
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Problems solved by technology

It can be seen that although the ADA level of pleural fluid has a high diagnostic efficiency in tuberculous pleurisy, it does not have good specificity in

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  • Application of GSDMD as biomarker in differential diagnosis and curative effect evaluation of pleural effusion related diseases
  • Application of GSDMD as biomarker in differential diagnosis and curative effect evaluation of pleural effusion related diseases
  • Application of GSDMD as biomarker in differential diagnosis and curative effect evaluation of pleural effusion related diseases

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Embodiment Construction

[0021] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

[0022] Pyroptosis is an inflammatory programmed cell death type induced by pathogens and dependent on Caspase-1 or Caspase-11 / 4 / 5 activation, and the N-terminal domain (NT-GSDMD) produced by its lysate GSDMD induces and activates and secretes Two major proinflammatory cytokines: interleukin-1β (IL-1β) and IL-18. GSDMD is a 480 amino acid protein consisting of a C-terminal inhibitory domain and an N-terminal pore-forming domain, which ...

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Abstract

The invention belongs to the technical field of biomarkers, and particularly discloses application of GSDMD as a biomarker in differential diagnosis and curative effect evaluation of pleural effusion related diseases. It is found for the first time that the GSDMD level is remarkably increased in pleural fluid caused by tuberculous pneumonia, pulmonary infection and pulmonary malignant tumors, and the GSDMD is a reliable biomarker for differential diagnosis of lung diseases; meanwhile, the GSDMD level is remarkably related to the anti-infection treatment effect of the lung diseases. By quantitatively analyzing the GSDMD level of pleural effusion, an objective basis can be provided for early judgment of common lung diseases, and an objective basis can be provided for formulating a reasonable treatment scheme for lung anti-infection treatment. On the working basis of the invention, a corresponding GSDMD detection kit can be directly transformed and developed, so as to carry out early differential diagnosis and curative effect evaluation on pleural effusion related diseases. The GSDMD has good clinical application value.

Description

technical field [0001] The invention relates to the technical field of biomarkers, in particular to the use of GSDMD as a biomarker in the differential diagnosis and curative effect evaluation of pleural effusion-related diseases. Background technique [0002] Pleural effusion (PE, also known as pleural effusion) often occurs in patients with respiratory medicine. Accumulation of pleural fluid increases when pathological processes result in an imbalance between fluid formation and absorption, including in the setting of systemic disease, pulmonary disease, and organic dysfunction. Tuberculous pneumonia, pulmonary infection, and malignant lung disease are the most common causes of pleural effusion formation. [0003] The appearance of pleural effusion usually indicates pleural cavity disease, and the biochemical analysis of pleural effusion is widely used in the detection of clinical samples to distinguish the cause of pleural effusion. Although traditional biomarkers such ...

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/12
Inventor 李朴庄志史静
Owner 李朴
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