A composite hydrogel for diabetic foot wound dressing, its preparation method and application

A composite hydrogel, diabetic foot technology, applied in the field of composite hydrogel, can solve the problems of lack of adhesion function, slow wound healing, aggravated wounds, etc., and achieves a simple and controllable preparation method, saving medical costs, reducing The effect of pressure on the affected area

Active Publication Date: 2022-07-01
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, most hydrogel dressings lack adhesion function, and it is difficult to form an effective fit with the tissue during use, which affects the therapeutic effect
In addition, when diabetic foot patients are mild or in the early stage of the disease, the soles of their feet are affected by pressure or shear force during activities, resulting in insufficient blood supply and susceptibility to bacterial infection, which may aggravate the condition and worsen the wound
In addition, diabetic foot ulcers are slow to heal due to bacterial infection and inflammatory reactions.

Method used

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  • A composite hydrogel for diabetic foot wound dressing, its preparation method and application
  • A composite hydrogel for diabetic foot wound dressing, its preparation method and application
  • A composite hydrogel for diabetic foot wound dressing, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 3.7g tannic acid (Tannic acid), 22.3g [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfonic acid propyl)ammonium hydroxide (SBMA, namely methacrylic acid sulfonic acid acid betaine), 90mg polyethylene glycol diacrylate (PEGDA, M W =700), 23 mg of ammonium persulfate (ie, APS) was added to 20 mL of deionized water to obtain a prepolymerized solution. The prepolymer solution was deoxygenated by passing nitrogen gas for 30min, the deoxygenated prepolymer solution was injected into a closed glass mold, placed in a 60°C water bath overnight, and the hydrogel was prepared by thermally induced free radical polymerization (such as figure 1 shown). The hydrogel prepared in this example was named T8S4.

Embodiment 2

[0061] 1.8g tannic acid, 22.3g SBMA, 90mg PEGDA (M W =700), 23 mg of ammonium persulfate was added to 20 mL of deionized water to obtain a prepolymerized solution. The prepolymer solution was deoxygenated by passing nitrogen gas for 30min, the deoxygenated prepolymer solution was injected into a closed glass mold, placed in a 60°C water bath overnight, and the hydrogel was prepared by thermally induced free radical polymerization (such as figure 1 shown). The hydrogel prepared in this example was named T4S4.

Embodiment 3

[0063] 0.9g tannic acid, 22.3g SBMA, 90mg PEGDA (M W =700), 23 mg of ammonium persulfate was added to 20 mL of deionized water to obtain a prepolymerized solution. The prepolymer solution was deoxygenated by passing nitrogen gas for 30min, the deoxygenated prepolymer solution was injected into a closed glass mold, placed in a 60°C water bath overnight, and the hydrogel was prepared by thermally induced free radical polymerization (such as figure 1 shown). The hydrogel prepared in this example was named T2S4.

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Abstract

The present application provides a composite hydrogel, its preparation method and application in the preparation of wound dressings for preventing and treating diabetic foot, the composite hydrogel comprises a zwitterionic polymer and a plant polyphenol compound, wherein, Zwitterionic polymers are formed by chemical crosslinking of zwitterionic monomers, and plant polyphenolic compounds are physically crosslinked with zwitterionic polymers. The above preparation method includes 1) dissolving plant polyphenolic compounds, zwitterionic monomers, chemical cross-linking agents and initiators in deionized water, and mixing them uniformly to obtain a prepolymerization solution; (2) dissolving the oxygen in the prepolymerization solution and (3) the prepolymerization solution undergoes radical polymerization under preset conditions to obtain the composite hydrogel. The composite hydrogel of the present application has significantly improved tissue adhesion, compression properties, plantar decompression properties, antioxidant properties, and antibacterial properties. The above preparation method is simple and the reaction process is controllable.

Description

technical field [0001] The application relates to a composite hydrogel, belonging to the technical field of biomedical materials; in particular, to a composite hydrogel used for diabetic foot wound dressings, a preparation method thereof, and its application in antibacterial, plantar decompression and wound dressing Repair application. Background technique [0002] Diabetes is a chronic disease, and its incidence is increasing year by year worldwide. Diabetic foot ulcer is one of the most serious complications of diabetes, and about 25% of diabetic patients will develop a diabetic foot ulcer. If diabetic foot ulcers are not treated effectively, the long-term non-healing of the ulcers in severe cases will bring the risk of amputation to the patients and have a great impact on the patients' lives. Wound dressings can maintain the moist environment of the ulcer and release bioactive substances, thereby reducing ulcer infection and accelerating wound healing, and play an impor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08F283/06C08F220/38C08F222/38
CPCA61L26/0014A61L26/008A61L26/0066C08F283/065C08F220/387A61L2300/216A61L2300/404C08F222/385C08L33/14C08L51/08
Inventor 王荣顾钦玮方堃徐婷
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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