Three-dimensional printing composite inorganic nanofiber scaffold as well as preparation and application thereof

A technology of inorganic nanofibers and 3D printing, which can be used in prostheses, drug delivery, tissue regeneration, etc., can solve the problems of insufficient application form of bone repair materials, poor performance of personalized customization, etc., and achieve excellent degradation performance and strong feasibility , Simple and convenient operation

Active Publication Date: 2021-07-23
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a three-dimensional printing composite inorganic nanofiber scaffold and its preparation and application, so as to overcome the defects of poor personalized customization performance and insufficient application form of bone repair materials in the prior art

Method used

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  • Three-dimensional printing composite inorganic nanofiber scaffold as well as preparation and application thereof
  • Three-dimensional printing composite inorganic nanofiber scaffold as well as preparation and application thereof
  • Three-dimensional printing composite inorganic nanofiber scaffold as well as preparation and application thereof

Examples

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Embodiment 1

[0057] (1) PVP ethanol solution: Weigh 1.65 g of PVP (Shanghai Titan Science and Technology Co., Ltd.) with a molecular weight of 1,300,000, dissolve it in 10 mL of ethanol (≥95%, Sinopharm Chemical Reagent Co., Ltd.) under a magnetic stirrer, and prepare Obtain PVP ethanol solution.

[0058] (2) Biological glass salt solution: Tetraethyl orthosilicate (98%, Ron's reagent) weighed 1.34g, triethyl phosphate (99.5%, Ron's reagent) weighed 0.116g, calcium nitrate tetrahydrate (500g , Beijing Yinuokai Technology Co., Ltd. Shanghai Branch) weighed 0.148g, strontium nitrate (≥99.5%, Shanghai test) weighed 0.132g, 1mol / L HCL 0.1mL, absolute ethanol 4mL, deionized Measure 3 mL of water, and prepare a biological glass saline solution under the action of a magnetic stirrer.

[0059] (3) Preparation of spinning solution: mix the PVP ethanol solution, biological glass salt solution and hexafluoroisopropanol prepared in (1) and (2) according to the volume ratio of 2:2:1, and act on a magn...

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Abstract

The invention relates to a three-dimensional printing composite inorganic nanofiber scaffold as well as preparation and application thereof. The scaffold is a hollow cylindrical scaffold loaded with inorganic material aerogel. The preparation method is simple in technology, good in repeatability and excellent in personalized customization performance, and can provide a substitute for defect repair of large sections of bones.

Description

technical field [0001] The invention belongs to the field of large-segment bone repair bracket and its preparation and application, in particular to a three-dimensional printing composite inorganic nanofiber bracket and its preparation and application. Background technique [0002] Inorganic nanofibers are mainly composed of metals and oxides, non-metals and oxides, salts, etc., and the main inorganic component of bone in living organisms is hydroxyapatite. Synthetic materials such as bioactive glass, borosilicate and other inorganic materials, which are biological materials composed of basic inorganic components such as SiO2, Na2O, CaO, B2O3 and P2O5, are highly similar to human bone tissue components. The most notable feature of inorganic materials such as bioactive glass and borosilicate is that after being implanted into the human body, the surface condition changes dynamically over time, and a bioactive hydroxycarbonated apatite layer forms on the surface, providing a b...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/04A61L27/56A61L27/50A61L27/22A61L27/18B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/10A61L27/047A61L27/56A61L27/50A61L27/222A61L27/18B33Y10/00B33Y70/10B33Y80/00A61L2430/02A61L2400/12C08L67/04
Inventor莫秀梅袁征超王晓宇徐小青吴凡沈威
OwnerDONGHUA UNIV